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Ple4.5
Polypodium Leucotomos – Forschung
Überwiegend Mechanismus / Beobachtung
19 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Polypodium Leucotomos sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 40 Teilnehmenden.
Basierend auf 19 Studien · 13 RCTs · 312 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Skin healthUnterstützt die Photoprotektion und das Erscheinungsbild lichtgealterter Haut · 12 weeks · Ergänzt Sonnenschutz zur Photoprotektion; beschleunigt die Besserung von Melasma · 4-12 weeks
Überwiegend Mechanismus / Beobachtung12 Studien
Safety profile
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
9 Studien in den letzten 5 Jahren
200620162026
1RCT2006
Reyes E, Jaén P, de las Heras E, Carrión F, Alvarez-Mon M, de Eusebio E · J Dermatol Sci (2006)
Einfach gesagt: This study supports oral supplementation as an adjunct to topical photoprotection, with prolonged use potentially yielding cumulative benefits.
Keršmanc P, Pogačnik T, Žmitek J, Hristov H, Točkova O, Žmitek K. · Nutrients (2025)
While these changes were not statistically significant after 2 weeks, they reached significance after 8 weeks of intervention.
By the end of the study, the IP group exhibited a significant 23.8% increase in MED (from 0.447 ± 0.096 to 0.553 ± 0.142 J/cm 2 ; p < 0.05) and a 46.2% reduction in erythema intensity (from 2.40 ± 0.94 to 1.29 ± 1.04 au; p < 0.0001).
In contrast, ΔMI in the IP group (from 0.67 ± 0.81 to 0.82 ± 0.96 au) were comparable to those observed in the placebo group, with no significant differences between groups.
Einfach gesagt: Future clinical trials should focus on diverse populations at higher risk of skin cancer and explore new ingredients as well as combinations of various ingredients to optimize therapeutic applications.
Rodríguez-Luna A, Zamarrón A, Longo C, Pellacani G, Peris K, Calzavara-Pinton P, de Galvez MV, Gilaberte Y, de Troya M, Juarranz Á, González S. · Actas dermo-sifiliograficas (2025)
Vitamin supplementation studies revealed mixed results, with clear data showing benefits in reducing the risk of precancerous lesions and skin cancers after nicotinamide (NAM) treatment, while others did not demonstrate significant protective effects.
Conclusions The review confirms the efficacy of polyphenols in preventing and treating AKs and related skin conditions.
However, the role of vitamins and other supplements requires further investigation due to inconsistent and/or scarce findings.
Einfach gesagt: Further research should investigate the relation between these findings and the chemopreventive effect of NAM and PL on skin cancer.
Faisal A, Lerche CM, Douki T, Philipsen PA, Pihl C, Gregersen T, Granborg JR, Bjerring P, Haedersdal M, Wiegell SR. · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (2026)
Results Both NAM and PL increased MED by 26%.
With a median MED of 27.7 J/cm² (13.4-51.1 J/cm²) pre-NAM and 34.8 J/cm² (13.4-62.5 J/cm²) post-NAM (p = 0.0008).
And A median MED of 27.7 J/cm² (13.4-51.1 J/cm²) pre-PL and 34.8 J/cm² (16.4-62.5 J/cm²) post-PL (p = 0.0002).
Einfach gesagt: Comprehensive, behaviour-based photoprotection programmes are essential for high-risk groups.
Gilaberte Y, Ederra-Galé A, García-Alfonso JJ, Gracia-Cazaña T. · Cancers (2026)
Results : Daily sunscreen use significantly reduces AK and cutaneous squamous cell carcinoma in high-risk individuals, although evidence for basal cell carcinoma and melanoma prevention remains heterogeneous.
Topical and especially oral nicotinamide demonstrate chemopreventive potential in immunocompetent patients.
Vulnerable populations-including transplant recipients, XP patients, individuals with albinism, and outdoor workers-require tailored photoprotection strategies with demonstrated benefit.
Einfach gesagt: The oral PLE aqueous extract product appears to be a safe and effective adjunctive treatment for melasma in combination with topical hydroquinone and sunscreen.
Goh CL et al. · J Clin Aesthet Dermatol (2018)
Oral PLE accelerated melasma improvement with hydroquinone + SPF50
Randomized placebo-controlled trial (n=40)
17Übersicht2015
Einfach gesagt: This review concludes PLE is well tolerated at all doses administered and associated with a negligible risk of side effects.
Winkelmann RR et al. · J Drugs Dermatol (2015)
Photoprotective and antioxidant effects (Fernblock)
Used adjunctively for photodermatoses, melasma, vitiligo
Evidence mostly from small trials
18Übersicht2014
Einfach gesagt: Orally administered Polypodium leucotomos also appears to provide adjunctive benefits in treating vitiligo, melasma, and may have the potential to help with postinflammatory hyperpigmentation.
Nestor M et al. · J Clin Aesthet Dermatol (2014)
Adjunct for pigmentary disorders (melasma, vitiligo, PMLE)
Modest adjunctive evidence
19Systematische Übersicht2025
Einfach gesagt: A systematic review of oral photoprotective supplements supported Polypodium leucotomos for modest photoprotection.