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Pom5.6
Pomegranate – Forschung
Überwiegend Mechanismus / Beobachtung
24 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Pomegranate sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2016–2026 mit einer typischen Studiengröße von 2,023 Teilnehmenden.
Basierend auf 24 Studien · 5 Meta-Analysen · 3 RCTs · 4,746 Teilnehmende insgesamt
23 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
201620212026
1Systematische Übersicht2026
It is hoped that this review will encourage further investigations on pomegranate in order to identify the compounds (or their metabolites) responsible for biological activity and unravel their mode(s) of action at the molecular level.
Kitic D, Miladinovic B, Randjelovic M, Szopa A, Seidel V, Sharifi-Rad J, Setzer WN, Calina D. · Phytotherapy research : PTR (2026)
Pomegranate (Punica granatum L.) is a plant that has been used in traditional medicine for centuries and that has gain popularity in recent years as an anticancer dietary supplement.
For the purpose of this review, a comprehensive literature search was performed to gather articles published between 1993 and 2021 and describing the therapeutic potential of pomegranate fruit extracts, juice, and seed oil on breast, colon, and prostate cancer.
The results of the studies highlighted the fact that while the consumption of pomegranate has been associated with a number of beneficial effects on cancer, it still remains unclear which chemicals are responsible for such effects.
The health effects of pomegranate should be interpreted within a nutrition-focused, matrix-dependent framework integrating composition, processing, bioavailability, and microbiota-derived metabolism.
Kobylińska Z, Bochno A, Och E, Kotula M, Kielar P, Galiniak S, Mołoń M. · Nutrients (2026)
Reported biological activities include antioxidant, anti-inflammatory, antimicrobial, metabolic, anti-aging, and anticancer effects.
These actions appear to result from synergistic interactions among multiple bioactive compounds rather than from a single dominant constituent.
Importantly, gut microbiota-driven conversion of ellagitannins and ellagic acid into urolithins is a major determinant of systemic bioactivity and may contribute to interindividual variability in response.
However, further large-scale, long-term RCTs are warranted to confirm these effects and explore synergistic benefits with standard lipid-lowering therapies.
Cheng W, Liang K, Huang A. · Prostaglandins & other lipid mediators (2025)
Results indicated that pomegranate intake significantly increased HDL-C levels (mean difference: 2.50 mg/dL, 95 % CI: 1.00-4.00, p < 0.05), while no significant changes were observed in TC, LDL-C, or TG.
Heterogeneity across studies was attributed to variations in intervention duration, dosage forms, and participant characteristics.
Publication bias was nonsignificant (Egger's test, p > 0.05).
Emerging research indicates that pomegranate can potentially prevent and treat different cancers, including prostate, bladder, breast, skin, lung, and colon cancer.
Rauf A, Olatunde A, Akram Z, Hemeg HA, Aljohani ASM, Al Abdulmonem W, Khalid A, Khalil AA, Islam MR, Thiruvengadam R, Kim SH, Thiruvengadam M. · Food science & nutrition (2025)
Incorporating diverse vegetables and fruits into one's dietary regimen exhibits promising potential for preventing a minimum of 20% cancer incidence and approximately 200,000 cancer-related mortalities annually.
Furthermore, they exhibit antioxidant properties and have garnered extensive approval for their use as nutritional supplements.
Pomegranates are used in ancient cultures to prevent and treat various diseases.
5Systematische Übersichtn=2,023 · very large study2024
However, given that the majority of the included articles were animal studies, further investigations in the form of human clinical trials are warranted to suggest a clinical indication of such interventions.
Tangestani H, Jamshidi A, Farhadi A, Ghalandari H, Dehghani P, Moghaddas N, Safaei Z, Emamat H. · Phytotherapy research : PTR (2024)
Afterward, irrelevant articles were removed and the full texts of the remaining 27 articles were reviewed.
Eventually, 19 articles (16 animal and three human interventional studies) that met the inclusion criteria, published between 2009 and 2023, were included in this systematic review.
Our study indicates the potential beneficial effects of different parts of pomegranate on the improvement of NAFLD.
Addressing these issues through emerging strategies such as nanoencapsulation, oleogel systems, edible films, and plant-based matrices could expand the applications of pomegranate-based ingredients and strengthen their role in health-promoting, sustainable, and market-relevant functional foods.
Brito IPC et al. · Food research international (Ottawa, Ont.) (2026)
Addressing these issues through emerging strategies such as nanoencapsulation, oleogel systems, edible films, and plant-based matrices could expand the applications of pomegranate-based ingredients and strengthen their role in health-promoting, sustainable, and market-relevant functional foods.
In conclusion, a novel PB showed promise for attenuating muscle pain and perceived exhaustion, and improving sleep quality, in the days after muscle damaging exercise.
Thorley J et al. · Nutrients (2026)
There was an interaction effect for pressure pain threshold in the vastus lateralis (p = 0.041), which was ~21% higher in PB 72 h post-exercise (p = 0.074; ds = 0.767).
Perceived sleep quality was greater 72 h post-exercise in PB (p = 0.049; rrb = 0.423) and those in the PB condition reported feeling more recovered and less mentally drained post-exercise (p ≤ 0.043).
There were no statistically significant between-condition differences for any markers of neuromuscular function, inflammation, oxidative stress or muscle damage (p > 0.05).
Punicalagin's multitarget actions support its translational potential in the management of CVD.
Kaur G, Chauhan R, Kashyap G, Goyal J, Mittal N, Kumar P, Devi S. · Journal of Asian natural products research (2026)
This evidence-based review highlights the cardioprotective potential of punicalagin, a major polyphenolic ellagitannin from Punica granatum L., focusing on its pharmacological mechanisms in cardiovascular disease (CVD) pathogenesis.
Clinical trials further support these effects, showing improvements in lipid profile, blood pressure, and carotid intima-media thickness.
Punicalagin's multitarget actions support its translational potential in the management of CVD.
Larger, well-designed, multicenter randomized controlled trials are warranted to confirm both efficacy and safety before clinical recommendation.
de Carvalho JF, Hautz E. · Clinical nutrition ESPEN (2026)
In RA, supplementation with pomegranate extract or juice resulted in significant reductions in DAS28 scores, ESR, and CRP, accompanied by enhanced antioxidant activity.
In OA, four randomized trials demonstrated significant improvements in WOMAC, KOOS, and VAS scores, decreased inflammatory biomarkers (IL-6, TNF-α), and enhanced antioxidant capacity.
The overall certainty of evidence was graded as low to very low, primarily due to small sample sizes, heterogeneous interventions, and short follow-up durations.
In highly trained male volleyball athletes, short-term POMj did not outperform placebo on group-mean recovery outcomes at 48 h post-EIMD; however, SWC-based analyses showed a higher proportion of meaningful responders with POMj in selected high-velocity isokinetic measures, supporting responder-focused evaluations of recovery nutraceuticals in sport-specific settings.
Rezaei G et al. · Journal of the International Society of Sports Nutrition (2026)
ANOVA revealed a significant main effect of time for most variables (p < 0.05), indicating recovery or changes across 48 h; however, no significant between-condition differences (POMj vs.
Although the knee extensor peak torque at 180° s-1 significantly improved from baseline within the POMj (p = 0.002), this recovery was not statistically superior to that of the PLA (p = 1.000).
Similarly, DOMS increased significantly over time (p = 0.001), with no significant difference between conditions.
This review contributes to the discourse on the medicinal value of pomegranate, offering a comprehensive understanding of its role in addressing diverse health conditions and highlighting the importance of integrating medicinal plants such as pomegranate into modern nutrition and clinical practice.
Shetty A, Dubey A, Rodrigues VP, Kamath S, Fernandes L, Mahadev M, Jain P, Hebbar S. · Nutrition reviews (2026)
Notably, punicalagin exhibits antifungal activity via sterol 14-demethylase P450 (CYP51) inhibition, supported by molecular docking studies.
Although pomegranate demonstrates an excellent safety profile with minimal reported adverse events, further long-term, well-designed clinical trials are essential to validate its efficacy, determine optimal dosing, and enable standardized therapeutic use.
This review contributes to the discourse on the medicinal value of pomegranate, offering a comprehensive understanding of its role in addressing diverse health conditions and highlighting the importance of integrating medicinal plants such as pomegranate into modern nutrition and clinical practice.
This review provides an overview of the metabolomic profile of pomegranate, its therapeutic potential, safety, and quality control assessments, and strategies to enhance the stability and bioavailability of its active constituents, thus underscoring its potential as a natural intervention for the prevention and treatment of NCDs.
Rahman AU, Esa M, Panichayupakaranant P. · Food & function (2025)
Moreover, pomegranate extracts have exhibited hypoglycemic, nephroprotective, hepatoprotective, antidepressant, anti-Alzheimer's, and anti-Parkinson's properties, as demonstrated in in vitro and in vivo studies, and clinical trials.
Recent investigations have identified key bioactive constituents, including punicalagin, ellagic acid, gallic acid, and urolithin A, as major contributors to these therapeutic effects.
Analyzing pomegranate's functional and nutritional properties, especially its peel and seed, is crucial for understanding the mechanisms involved in industrial processes for nutraceutical or functional food products.
Noreen S, Hashmi B, Aja PM, Atoki AV. · Frontiers in nutrition (2025)
Results Pomegranate and its by-products are rich in beneficial phytochemicals, provide health benefits, and help manage ailments.
Sustainable reuse of its by-products supports health, economic growth, and food security.
Conclusion Pomegranate provide health benefits, including antidiabetic, antioxidant, anticancer, and anti-inflammatory effects, with potential for food product development and disease management.
Through comprehensive search of available literature, this narrative review can provide an up-to-date overview of the current knowledge of characteristic bioactive constituents's structure and potential health benefits of Pomegranate, which can be used as reference for the future clinical and basic research, and also helpful for the development of pomegranate into functional food and nutraceuticals.
It is a fruit-bearing tree, which is widely consumed as a nutraceutical source as well as functional food for putative health benefits.
The phenolic components are the characteristic bioactive constitutes of pomegranate, including hydrolysable tannins, flavonoids, and phenolic acids.
The whole plant of this tree has many medicinal folkloric uses and good therapeutic effect, such as anticancer, antioxidant, antibacterial, antiviral, hypoglycemic, lipid-lowering, cardioprotection and digestive system protection.
Existing data suggests that additional research on the beneficial antioxidant, anti-inflammatory, anti-proliferative, and anti-nociceptive effects of pomegranate extracts for benign gynecologic conditions is warranted.
El Sayed S, Macri VI, Singh B, Segars JH, Islam MS. · Reproductive sciences (Thousand Oaks, Calif.) (2025)
Pomegranate extract decreased testosterone levels, levels of oxidative stress and inflammation biomarkers in women with polycystic ovary syndrome, erstwhile favorably impacting some cardiovascular risk factors in women.
Pomegranate supplementation improved menopause specific health-related quality of life in women.
In a pre-clinical murine model following ovariectomy, improved bone formation and reduced vaginal atrophy were associated with pomegranate treatment.
In the future, supplementation with pomegranate extracts, polyphenols, or urolithins could represent a valuable low-risk complementary therapy for patients with difficult-to-manage diseases, as well as a valid therapeutic alternative for the topical or systemic treatment of skin pathologies.
Cordiano R, Gammeri L, Di Salvo E, Gangemi S, Minciullo PL. · Molecules (Basel, Switzerland) (2024)
This review aims to summarize and discuss the evidence of the benefits of pomegranate extract and its compounds to slow the aging processes by intervening in the mechanisms underlying inflammaging.
These studies mainly concern neurodegenerative and skin diseases, while studies in other fields of application need to be more practical.
Furthermore, no human studies have demonstrated the anti-inflammaging effects of pomegranate.
Future research directions are proposed to better understand the mechanisms underlying the health benefits of pomegranates and to optimize their use in preventive and therapeutic contexts.
Mohan M, C A M, D P, V AG. · Cureus (2024)
This review also examines traditional and contemporary uses of pomegranates in medicine and cuisine, highlighting their cultural significance and potential therapeutic applications.
Despite promising findings, limitations in current research methodologies and the need for more robust clinical trials are discussed.
Future research directions are proposed to better understand the mechanisms underlying the health benefits of pomegranates and to optimize their use in preventive and therapeutic contexts.