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K8.5
Potassium – Forschung
Hilft vermutlich
42 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Potassium half in etwa der Hälfte (9/14) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2013–2026 mit einer typischen Studiengröße von 608 Teilnehmenden.
Basierend auf 42 Studien · 15 Meta-Analysen · 13 RCTs · 343,503 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
9geholfen4unklar1nicht geholfen· 28 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureSenkt den Blutdruck und das Risiko für Herz-Kreislauf-Erkrankungen · 4-8 weeks
Hilft vermutlich40 Studien
Kidney & renal health
Hilft vermutlich8 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung4 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Kidney stones & urolithiasis
Zu wenige bewertete Studien2 Studien
Weight management
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 29 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
43%
über Studien hinweg
Untersuchte Personen
344k
typische Studie: 608 Personen
Stärkste Designs
28
15 gepoolt, 13 randomisiert
Zeigte Nutzen
64%
9/14 Studien
Wie lange Studien liefen
3+ Monate
3
Untersuchte Populationen
General population4
General population and hypertensive populations1
Adults with hypertension1
Healthy adults1
Aktives Forschungsgebiet
37 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
201320192026
1Blood pressure controlMeta-AnalyseCited 3×n=2,500 · very large study2025
This meta-analysis highlights the dose-response relationship between potassium supplementation and BP reduction, particularly in subjects with hypertension.
Granal M et al. · Clinical Kidney Journal (2025)
Dose-response analysis of RCTs from 2000-2024
Significant blood pressure reductions
Benefits most pronounced in hypertensive populations
2Meta-AnalyseCited 15×n=237,036 · very large study2024
Our study demonstrates significant positive associations between daily sodium intake (within the range of sodium intake between 2,000 and 7,500 mg/d), the sodium-potassium ratio, and risk of CVD and overall mortality, with women having stronger sodium-potassium ratio-mortality associations than men, and with the meta-analysis providing compelling support for the CVD associations.
6Blood pressure reductionMeta-AnalyseCited 113×n=923 · large study2020
Aerobic exercise, isometric training, low-sodium and high-potassium salt, comprehensive lifestyle modification, salt restriction, breathing-control, meditation and low-calorie diet also have obvious effects on BP reduction.
Fu J et al. · Journal of the American Heart Association (2020)
Among overweight and obese participants, low-calorie diet and low-calorie diet plus exercise could lower more BP than exercise.
Conclusions DASH might be the most effective intervention in lowering BP for adults with prehypertension to established hypertension.
Aerobic exercise, isometric training, low-sodium and high-potassium salt, comprehensive lifestyle modification, salt restriction, breathing-control, meditation and low-calorie diet also have obvious effects on BP reduction.
7Global mean potassium intakeMeta-AnalyseCited 48×n=104 · medium study2023
Global mean potassium intake (2.25 g/day) falls below current guideline recommended intake level of > 3.5 g/day, with only 14% (95% CI 11-17%) of the global population achieving guideline-target mean intake.
Reddin C et al. · European journal of nutrition (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Approximately 31% (95% CI, 30-41%) of global population included have an estimated potassium intake > 2.5 g/day, with 14% (95% CI 11-17%) above 3.5 g/day.
Global mean potassium intake (2.25 g/day) falls below current guideline recommended intake level of > 3.5 g/day, with only 14% (95% CI 11-17%) of the global population achieving guideline-target mean intake.
There was considerable regional variation, with lowest mean potassium intake reported in Asia, and highest intake in Eastern and Western Europe.
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
Behers BJ et al. · Nutrients (2024)
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
Future studies are needed to validate these findings and provide tailored recommendations.
These studies could investigate varying dosages over long-term follow-up to provide robust data on optimal dosages and treatment durations, as our findings were limited due to reliance on previously published trials.
9Obesity and metabolic syndrome riskMeta-AnalyseCited 61×2016
However, additional pertinent studies are needed to examine the underlying mechanism.
Cai X et al. · Nutrients (2016)
Kein klarer Effekt
← SchlechterKein EffektBesser →
The results of the pooled analysis and systematic review indicated that high potassium intake could not reduce the risk of obesity (pooled OR = 0.78; 95% CI: 0.61-1.01), while serum potassium and urinary sodium-to-potassium ratio was associated with obesity.
Potassium intake was associated with metabolic syndrome (pooled OR = 0.75; 95% CI: 0.50-0.97).
Nonlinear analysis also demonstrated a protective effect of adequate potassium intake on obesity and metabolic syndrome.
10Potassium intake associated with Mediterranean diet adherenceSystematische Übersichtn=263 · medium study2026
Higher MDP adherence is generally associated with higher potassium intake, but estimates vary by how MDP adherence is defined and scored, the potassium assessment method, and population context.
D'Elia L et al. · Nutrients (2026)
Higher MDP adherence is generally associated with higher potassium intake, but estimates vary by how MDP adherence is defined and scored, the potassium assessment method, and population context.
Current evidence remains insufficient to quantify potassium's potential contribution as a candidate mediator without formal mediation analyses and robust exposure assessment, including repeated validated 24 h urine collections.
Standardised scoring, routine reporting of potassium, sodium, and the Na/K ratio, and triangulation across dietary, biomarker and intervention evidence are key priorities to strengthen inference.
Hoorn EJ et al. · Nature reviews. Nephrology (2026)
However, whether the cardiorenal benefits of adequate potassium intake in CKD outweigh the risk of hyperkalaemia remains uncertain.
A clearer understanding of the relationship between dietary potassium intake and blood potassium levels, as well as the optimal blood potassium range for kidney and cardiovascular health, is needed to resolve this question.
12blood pressure, cardiovascular events and mortalityMeta-Analysen=37,063 · very large study2026
Salt substitutes, particularly moderate-potassium and low-sodium formulations, represent a promising sodium reduction strategy.
Lai H et al. · BMC medicine (2026)
Salt substitutes, particularly moderate-potassium and low-sodium formulations, represent a promising sodium reduction strategy.
However, current evidence for mortality and cardiovascular event benefits is dominated by one large Chinese trial and has very limited generalisability beyond Chinese populations with high discretionary salt use.
These products appear acceptable and safe in people without renal impairment, but clinicians should rule out kidney disease and hyperkalaemia risk before recommending them, and large trials in non-Chinese populations are needed.
13hyperkalemia-related treatment rateRCTn=14,989 · very large study2026
This rct examined the effects of Potassium.
Lin C et al. · Nature communications (2026)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
Overall, the rate of hyperkalemia-related treatment was not significantly greater in the intervention group (8.0%) than in the control group (7.7%) (hazard ratio 1.05; 95% CI 0.94-1.17; p = 0.420).
Similarly, the rate of hypokalemia-related treatment did not differ significantly (2.1% vs. 2.4%; hazard ratio 0.91; 95% CI 0.74-1.13; p = 0.392).
Among patients identified by AI-enabled electrocardiography as having hyperkalemia, however, hyperkalemia-related treatment occurred more frequently in the intervention group (69.1% vs. 41.6%; hazard ratio 2.23; 95% CI 1.44-3.46; p < 0.001).
14Blood pressure reductionMeta-Analysen=1,430 · large study2026
In patients with hypertension, the use of a salt substitute is associated with a significant reduction in both SBP and DBP compared with regular salt.
Kelly FA et al. · Arquivos brasileiros de cardiologia (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Four RCTs involving 1,430 participants were included, of whom 725 (49.57%) received the salt substitute.
The use of a salt substitute was associated with a significant reduction in systolic BP (SBP) (MD, -5.75 mmHg; 95% CI, -6.98 to -2.39 mmHg; I2 = 37%; p < 0.01) and a significant reduction in diastolic BP (DBP) (MD, -1.62 mmHg; 95% CI, -2.34 to -0.91 mmHg; I2 = 0%; p < 0.001).
In patients with hypertension, the use of a salt substitute is associated with a significant reduction in both SBP and DBP compared with regular salt.
Our findings support the benefits of moderate potassium consumption for primary prevention of chronic diseases and premature death.
Fan Y, Wu M, Ding L, Ji H, Zhao J, Li X, Li Z, Liu S, Jiang H, Shi J, Lei H, Wang M, Wang D, Ma L. · Critical reviews in food science and nutrition (2024)
Random-effects models were used to pool the study-specific relative risks (RRs) and 95% confidence intervals (CIs).
A higher intake of potassium was significantly associated with a 16% lower risk of CVD (RR: 0.84, 95% CI: 0.78-0.90).
Each 1.0 g/d increment in potassium intake was associated with a decreased risk of CVD (RR: 0.85, 95% CI: 0.80-0.91) and all-cause mortality (RR: 0.93, 95% CI: 0.88-0.99).
16Insomnia severity and sleep hormone levelsRCTCited 7×n=320 · medium study2024
The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones).
Khalid S et al. · Frontiers in endocrinology (2024)
The study included 93 (32.1%) male and 197 (67.9%) female participants.
According to the analysis, there was a significant association between the treatment groups and ISI after the trial (post-trial), p = 0.0001.
The study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones).
17Red blood cell potassium uptake and kaliuresisRCTCited 7×n=18 · very small study2023
With similar plasma potassium increase, red blood cell potassium uptake and kaliuresis were higher after an acute load of potassium citrate as compared with potassium chloride alone or pretreatment with lisinopril.
Wouda RD et al. · Clinical journal of the American Society of Nephrology : CJASN (2023)
With similar plasma potassium increase, red blood cell potassium uptake and kaliuresis were higher after an acute load of potassium citrate as compared with potassium chloride alone or pretreatment with lisinopril.
Clinical trials are needed to test this hypothesis.
Rastmanesh R, Isacco CG, Vellingiri B, Pepoyan A, Marotta F, Tekin I, Catanzaro R. · Endocrine, metabolic & immune disorders drug targets (2026)
We reviewed the literature extensively on this topic to propose a hypothesis to address this problem and suggest a novel potential for K-rich, gluten-free diets in SS patients.
Based on causal associations, we propose that higher K absorption and cortisol secretion following gluten-free diets accompanied by K-rich diets in SS patients with low serum potassium levels, may confer a higher therapeutic potential.
Clinical trials are needed to test this hypothesis.
The study suggests that magnesium alone and magnesium coupled with potassium supplementation assist insomniac diabetics more effectively to regulate insulin resistance and increased blood sugar levels.
Khalid S et al. · Journal of investigative medicine : the official publication of the American Federation for Clinical Research (2026)
HOMA-IR analysis showed that pretreatment mean of T4 (Magnesium + Potassium group) was 3.01 ± 0. 54, and post-treatment mean was 2.54 ± 0.29, showing a significant reduction (p = 0.001).
There was a significant association among post-HOMA-IR scores of treatment groups (p = 0.001).
Fasting blood sugar levels showed that all groups, except placebo, had significant differences in levels (p = 0.001).
This mini review summarizes notable research on lifestyle factors and BP published in Hypertension Research and other leading journals from 2024 through the first half of 2025, with particular focus on sleep, air pollution, and dietary factors (mainly sodium and potassium).
Matsumoto C. · Hypertension research : official journal of the Japanese Society of Hypertension (2026)
Lifestyle is closely linked to blood pressure (BP), making lifestyle modification essential for BP management.
In 2024, numerous intriguing studies were reported on lifestyle factors and BP.
This mini review summarizes notable research on lifestyle factors and BP published in Hypertension Research and other leading journals from 2024 through the first half of 2025, with particular focus on sleep, air pollution, and dietary factors (mainly sodium and potassium).