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Ps8.5
Psyllium Husk – Forschung
Hilft wahrscheinlich
62 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Psyllium Husk scheint in 15 von 20 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1991–2026 mit einer typischen Studiengröße von 242 Teilnehmenden.
Basierend auf 62 Studien · 23 Meta-Analysen · 13 RCTs · 28,942 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
15geholfen1unklar4nicht geholfen· 42 weitere ohne bewertete Effektdaten
Nach Outcome
Cholesterol & lipidsLösliche Ballaststoffe senken das LDL-Cholesterin um 5-10 % · 4-8 Wochen
Hilft wahrscheinlich45 Studien
Digestive healthQuellende Ballaststoffe normalisieren die Darmfunktion und lindern Verstopfung · 1-3 Tage
Hilft vermutlich25 Studien
Glucose & metabolicSenkt das LDL-Cholesterin und verbessert die Glukoseantwort · 4-12 Wochen
Hilft wahrscheinlich9 Studien
Therapeutic & clinical
Hilft vermutlich8 Studien
Weight management
Hilft wahrscheinlich6 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Heart & blood pressureLösliche Ballaststoffe senken das LDL-Cholesterin um 5-10 % · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
In Zahlen
Aus 44 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
67%
über Studien hinweg
Untersuchte Personen
29k
typische Studie: 242 Personen
Stärkste Designs
36
23 gepoolt, 13 randomisiert
Zeigte Nutzen
75%
15/20 Studien
Wie lange Studien liefen
1–4 Wochen
2
Untersuchte Populationen
General population5
Adults3
Type 2 diabetes patients2
Adults with chronic constipation2
Aktives Forschungsgebiet
47 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199120082026
1faecal incontinence and constipation managementMeta-Analysen=1,598 · large study2024
There was evidence in favour of some conservative interventions, but these findings need to be confirmed by larger, well-designed controlled trials, which should include evaluation of the acceptability of the intervention to patients and the effect on their quality of life.
Todd CL, Johnson EE, Stewart F, Wallace SA, Bryant A, Woodward S, Norton C. · The Cochrane database of systematic reviews (2024)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Conservative interventions may result in a large improvement in faecal incontinence (standardised mean difference (SMD) -1.85, 95% confidence interval (CI) -3.47 to -0.23; 3 studies; n = 410; low-certainty evidence).
We interpreted SMD ≥ 0.80 as a large effect.
Physical therapies may result in a moderate improvement in constipation symptoms (SMD -0.62, 95% CI -1.10 to -0.14; 9 studies; n = 431; low-certainty evidence).
2HbA1c reductionMeta-AnalyseCited 26×n=2,685 · very large study2023
Galactomannans were the most effective dietary fiber for reducing the levels of HbA1c, fasting blood glucose, triglycerides, and LDL cholesterol in patients with type 2 diabetes.
Juhász AE et al. · The American journal of clinical nutrition (2023)
Galactomannans had the highest effect on reducing the levels of HbA1c (SUCRA: 92.33%) and fasting blood glucose (SUCRA: 85.92%).
With regard to fasting insulin level, HOMA-IR, β-glucans (SUCRA: 73.45%), and psyllium (SUCRA: 96.67%) were the most effective interventions.
Galactomannans were ranked first in reducing the levels of triglycerides (SUCRA: 82.77%) and LDL cholesterol (SUCRA: 86.56%).
3Body weight reductionMeta-AnalyseCited 11×n=6,171 · very large study2023
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Shahinfar H et al. · Pharmacological research (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
We conducted random-effects network meta-analysis with a Frequentist framework to estimate mean difference [MD] and 95% confidence interval [CI] of the effect of nutraceuticals on weight loss.
Supplementations with green tea (MD: -1.25 kg, 95%CI: -1.68, -0.82) and glucomannan (MD: -1.36 kg, 95%CI: -2.17, -0.54) demonstrated small weight loss, also the certainty of evidence was rated low.
Based on our findings, supplementations with nutraceuticals can result in a small weight loss in adults with overweight or obesity.
5Meta-AnalyseCited 1×n=2,769 · very large study2024
Analysis used a random effects model to determine weighted mean difference and 95% confidence intervals.
Zhu R et al. · Nutrition research (New York, N.Y.) (2024)
Analysis used a random effects model to determine weighted mean difference and 95% confidence intervals.
Compared with the control group, Plantago consumption significantly reduced total cholesterol (TC) by 0.28 mmol/L and low-density lipoprotein cholesterol (LDL-C) by 0.35 mmol/L, correlating to an estimated 7% decrease in cardiovascular event risk.
Additionally, TC and LDL-C were significantly lower in participants consuming Plantago husk or psyllium, and soluble fiber intake was specifically effective in lowering TC, LDL-C, and triglycerides.
7Constipation treatment responseMeta-AnalyseCited 66×n=1,251 · large study2022
Fiber supplementation is effective at improving constipation.
van der Schoot A et al. · The American journal of clinical nutrition (2022)
Groß Schaden
← SchlechterKein EffektBesser →
Likely real
Overall, 311 of 473 (66%) participants responded to fiber treatment and 134 of 329 (41%) responded to control treatment [RR: 1.48 (95% CI: 1.17, 1.88; P = 0.001); I2 = 57% (P = 0.007)], with psyllium and pectin having significant effects.
Fiber increased stool frequency [SMD: 0.72 (95% CI: 0.36, 1.08; P = 0.0001); I2 = 86% (P < 0.00001)]; psyllium and pectin had significant effects, and improvement was apparent only with higher fiber doses and greater treatment durations (≥4 weeks).
Fiber improved stool consistency (SMD: 0.32; 95% CI: 0.18, 0.46; P < 0.0001), particularly with higher fiber doses.
10Body weight changeMeta-Analysen=27 · very small study2025
In summary, this study found that psyllium significantly increased body weight.
Gholami Z et al. · Journal of health, population, and nutrition (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Borderline
The findings indicate that psyllium significantly increased body weight, with a WMD of 3.57 (95% confidence intervals: 1.43, 5.72; p-value < 0.05).
However, there was a non-significant decrease in BMI, with a WMD of -0.06 (95% confidence intervals: -0.68, 0.55; p-value > 0.05), and a non-significant decrease in WHR, with a WMD of -0.10 (95% confidence intervals: -0.34, 0.12; p-value > 0.05).
Additionally, there was a non-significant increase in WC, with a WMD of 0.72 (95% confidence intervals: -0.93, 2.37; p-value > 0.05).
11Induction and maintenance of remission in inflammatory bowel diseaseMeta-AnalyseCited 18×2025
Prebiotics, particularly FOS and germinated barley foodstuff, show potential as effective and safe dietary supplements for induction and maintenance of remission in UC, respectively.
Limketkai BN et al. · Inflammatory bowel diseases (2025)
Sehr groß Schaden
← SchlechterKein EffektBesser →
For induction of clinical remission in ulcerative colitis (UC), the fructooligosaccharide (FOS) kestose was effective (relative risk, 2.75, 95% confidence interval, 1.05-7.20; n = 40), but oligofructose-enriched inulin (OF-IN) and lactulose were not.
For maintenance of remission in UC, germinated barley foodstuff trended toward preventing clinical relapse (relative risk, 0.40; 95% confidence interval, 0.15-1.03; n = 59), but OF-IN, oat bran, and Plantago ovata did not.
Prebiotics, particularly FOS and germinated barley foodstuff, show potential as effective and safe dietary supplements for induction and maintenance of remission in UC, respectively.
13Weekly frequency of spontaneous bowel movementsMeta-AnalyseCited 8×n=399 · medium study2022
Among individuals with constipation, there is an overall low certainty of evidence indicating that kiwifruit may increase SBM when compared to placebo or psyllium.
Eltorki M et al. · Canadian journal of gastroenterology & hepatology (2022)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Seven RCTs, including 399 participants (82% female; mean age: 42 years (SD 14.6)), were included.
Compared with placebo (n = 95), kiwifruit extracts might increase the weekly frequency of SBM (MD: 1.36; 95% CI: -0.44, 3.16) with low certainty of evidence; moreover, it had an uncertain effect on BSS (SMD: 1.54; 95% CI: -1.33, 4.41) with very low certainty of evidence.
Additionally, compared with placebo (n = 119), kiwifruit or its extracts reduced abdominal pain (SMD: -1.44, 95% CI -2.83, -1.66) with moderate certainty of the evidence and improved frequency of straining (SMD: -0.29; 95% CI: -1.03, 0.47).
14Anthropometric and biochemical parameters in NAFLDMeta-AnalyseCited 41×n=242 · medium study2020
More prospective, controlled studies should be conducted to reveal specific details regarding the fiber type, dosage, and duration for optimal intervention.
Stachowska E et al. · Nutrients (2020)
These effects suggest the potential benefits of fiber consumption for NAFLD populations.
More prospective, controlled studies should be conducted to reveal specific details regarding the fiber type, dosage, and duration for optimal intervention.
15Treatment of gastroenterological diseasesSystematische Übersicht2024
Some clear recommendations for the use of phytotherapeutics to treat gastroenterological diseases show their great potential.
Utz S et al. · Zeitschrift fur Gastroenterologie (2024)
Some clear recommendations for the use of phytotherapeutics to treat gastroenterological diseases show their great potential.
Due to their wide range of effects, phytotherapeutics can be used very well as a complement to conventional medicines in case of complex regulatory disorders.
However, further methodologically well-conducted impact studies would be helpful in order to be able to make further recommendations.Thieme.
17Resolution of ulcersMeta-AnalyseCited 4×n=216 · medium study2020
The majority of patients receiving medical treatment for the management of SRUS experience resolution of their ulcers.
Qari Y et al. · Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association (2020)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
The pooled effect estimate of treatment efficacy revealed that, of the patients receiving medical treatment, 57% had resolution of their ulcers (PP 0.57; 95% CI; 0.41 to 0.73).
18Systematische ÜbersichtCited 31×n=444 · medium study2018
Considering the short duration of the trials, the lack of trials including newer laxatives and the low quality of some of the included trials, the long-term efficacy and safety of these laxatives are not conclusive.
Alsalimy N et al. · Journal of clinical pharmacy and therapeutics (2018)
Considering the short duration of the trials, the lack of trials including newer laxatives and the low quality of some of the included trials, the long-term efficacy and safety of these laxatives are not conclusive.
There is a need to conduct more robust RCTs that include newer agents to evaluate long-term outcomes.