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PSO4.5
Pumpkin Seed Oil – Forschung
Überwiegend Mechanismus / Beobachtung
18 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Pumpkin Seed Oil sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2011–2026 mit einer typischen Studiengröße von 100 Teilnehmenden.
Basierend auf 18 Studien · 1 Meta-Analyse · 6 RCTs · 2,054 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
BPH & lower urinary tract symptoms
Überwiegend Mechanismus / Beobachtung7 Studien
Hair & nails
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung7 Studien
Men's vitalityVerringerte DHT-vermittelte Effekte durch Hemmung der 5-Alpha-Reduktase, was Prostata- und Haargesundheit unterstützt · 8-12 Wochen · Linderung von BPH-Symptomen und Unterstützung der Harnwegsfunktion · 6-12 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
Women's healthVerbessertes HDL-Cholesterin und verbesserte arterielle Hämodynamik bei postmenopausalen Frauen · 6-12 Wochen · Modulation der DHT-Spiegel und androgensensitiver Gewebe durch Phytosterol-Aktivität · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressureModerate Senkung des systolischen Blutdrucks und der arteriellen Steifigkeit bei postmenopausalen Frauen · 6-8 Wochen
Zu wenige bewertete Studien2 Studien
Cholesterol & lipidsModerate Senkung des systolischen Blutdrucks und der arteriellen Steifigkeit bei postmenopausalen Frauen · 6-8 Wochen
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 9 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
2,054
typische Studie: 100 Personen
Stärkste Designs
7
1 gepoolt, 6 randomisiert
Wie lange Studien liefen
1–3 Monate
2
3+ Monate
1
Untersuchte Populationen
Menopausal women1
Patients with androgenetic alopecia1
individuals with hair loss1
Benign prostatic hyperplasia patients1
Aktives Forschungsgebiet
15 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
201120182026
1Systematische Übersicht2026
Continued research is warranted to explore their bioactivity, health effects in humans, and innovative applications in modern diets.
Kassa MG, Teferi DA. · Food science & nutrition (2026)
From a food science perspective, pumpkin seeds are versatile, being incorporated into snacks, bakery products, salads, soups, functional foods, and dietary supplements.
Pumpkin seed oil is valued for its favorable fatty acid profile and antioxidant content.
Integration of pumpkin seeds into food formulations enhances both nutritional quality and functional properties.
This healthy vegetable oil was reported by several in vitro and in vivo studies to have potential protective roles in oxidative stress, inflammation, cancer, and cardiovascular diseases.
Hu Z, Hu C, Li Y, Jiang Q, Li Q, Fang C. · Journal of the science of food and agriculture (2024)
From previous literature, PSO contains a large proportion of unsaturated fatty acids, with linoleic acid as the main component, and an amount of tocopherol, phytosterol, and phenolic acids.
Some differences in the yield, composition, and physicochemical properties of PSO can be associated with the pumpkin's cultivars and the extraction methods.
Some novel technologies involved in supercritical fluid extraction, enzyme-assisted aqueous extraction, and ultrasound-assisted extraction have been replacing the conventional technologies gradually as promising methods for the safe, non-polluting, and effective recovery of PSO.
3Cardiovascular and hormonal health benefitsSystematische Übersicht2022
Clinical studies have shown that pumpkin seed oil may be beneficial in the treatment of cardiovascular problems of menopausal women and ailments associated with imbalance of sex hormones.
Šamec D et al. · Comprehensive reviews in food science and food safety (2022)
We provide a comprehensive overview of pumpkin seed oil chemical composition, phytochemical content, biological activity, and safety, as well as the overview of production processes and contemporary use.
The main phytochemicals in pumpkin seed oil with health-related properties are polyphenols, phytoestrogens, and fatty acids, but carotenoids, squalene, tocopherols, and minerals may also contribute to health benefits.
Most studies have been conducted in vitro and support the claim that pumpkin seed oil has antioxidant and antimicrobial activities.
Studies of nutritional interventions with the highest-quality evidence showed the potential benefit of Viviscal, Nourkrin, Nutrafol, Lamdapil, Pantogar, capsaicin and isoflavone, omegas 3 and 6 with antioxidants, apple nutraceutical, total glucosides of paeony and compound glycyrrhizin tablets, zinc, tocotrienol, and pumpkin seed oil.
Drake L et al. · JAMA Dermatology (2023)
30 articles were included comprising 17 RCTs, 11 clinical studies, and 2 case series in individuals without known nutritional deficiency
Pumpkin seed oil was among the nutritional interventions with highest-quality evidence for hair loss treatment
Adverse effects were rare and mild for all nutritional therapies evaluated including pumpkin seed oil
Zhou L, Zhu W, Chen Y. · Frontiers in nutrition (2025)
Results showed that compared with placebo, standardized plant extracts (Nutrafol), apple extract (AMSbzs, AMS), tocotrienols, pumpkin seed oil (PSO), and a compound extract of Cistanche and Laminaria (MK-R7) significantly improved hair density.
Conclusion Dietary supplements have a positive impact on hair density, terminal hair density, and blind doctor evaluations in patients with androgenetic alopecia, with good tolerability.
They may serve as beneficial adjuncts or alternatives to conventional treatments.
7Systematische Übersichtn=13 · very small study2025
Key message Additional investigations through the conduct of high quality randomized, controlled trials with larger numbers of patients will help determine the effectiveness and safety of this class of compounds, either as monotherapy or as an addition to current pharmacological interventions.
Gupta AK, Wang H, Wang T, Talukder M. · Skin appendage disorders (2025)
The available data demonstrate considerable improvements in one or more parameters: total hair density, terminal hair density and hair diameter.
Procyanidin and cetirizine were investigated in more investigator-blinded, randomized controlled trials than other agents.
Minimal adverse events were observed; however, more robust clinical trial and long-term safety and efficacy data are warranted.
8hair loss treatment efficacy and safetySystematische Übersicht2025
Due to this variation in the quality of evidence, further well-designed randomized trials with larger sample sizes are required to confirm the efficacy of these HRs.
Ahmed A, Alali AM, Abdullah E, Alharbi MN, Alayoubi HM. · Skin appendage disorders (2025)
Key messages Natural and HRs show promise in treating HL.
However, many of these studies have limitations such as lack of long-term follow-up, small sample sizes, and short treatment durations.
Due to this variation in the quality of evidence, further well-designed randomized trials with larger sample sizes are required to confirm the efficacy of these HRs.
There is a need for more scientific research to better explore the efficacy of currently identified CAMs in treating AGA.
Ufomadu P. · Proceedings (Baylor University. Medical Center) (2024)
Results Natural ingredients like pumpkin seed oil, saw palmetto, melatonin extract, caffeine extract, and rosemary oil were effective in treating AGA either when compared to baseline or a definite AGA Western medication, such as minoxidil.
These natural agents also presented minimal side effects.
Conclusion Certain CAMs can be promising for hair loss treatment.
The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH.
Krishnamoorthi R et al. · Journal of ethnopharmacology (2024)
The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH.
Even though most conventional formulations, such as 5 alpha-reductase, are readily available, systemic assessment of the effectiveness and mechanism of action of the herbal constituents is still necessary to identify novel chemical moieties that can be further developed for maximum efficacy.
However, there exist abundant botanicals and medicinal plants across several regions of Africa, Asia, and the Americas, which can be further studied and developed for utilization as a potential phytotherapeutic for the management of BPH.
This review article will not only provide a detailed background on this ancient herbal component but will additionally overview all other major herbal alternatives including peppermint oil, tea tree oil, green tea, pumpkin seed oil, saw palmetto, and lavender oil and will summarize the latest clinical studies, which have tested their efficacy for the management of androgenetic alopecia.
Bin Rubaian NF, Alzamami HFA, Amir BA. · Clinical, cosmetic and investigational dermatology (2024)
To date, the only FDA approved medications for the treatment of androgenetic alopecia are finasteride and minoxidil.
A plethora of studies have been conducted testing the efficacy of various herbal compounds, but additional research is needed to further establish the concrete efficacy of such natural remedies in treating androgenetic alopecia.
Of late, rosemary oil has gained mass popularity as a promising natural alternative.
An updated meta-analysis consolidating the evidence base for pumpkin seed oil in BPH-related LUTS, directly relevant to the supplement's primary clinical indication.
Vahabi S et al. · Journal of Ethnopharmacology (2024)
Pumpkin seed oil significantly reduced IPSS scores compared to placebo across included trials
Peak urinary flow rate improved meaningfully in pumpkin seed oil groups
Adverse event profiles were comparable to placebo, supporting safety
16Augmentation index reductionRCTCited 6×n=23 · very small study2019
PSO improved arterial hemodynamics in postmenopausal women and therefore might be effective in the prevention and treatment of hypertension in this population.
Wong A et al. · Complementary Therapies in Clinical Practice (2019)
Borderline
Augmentation index (AIx), brachial and central systolic blood pressure significantly decreased following PSO (3 g/day for 6 weeks) but not placebo (P<0.05)
Arterial stiffness index (SI) and heart rate variability parameters remained unchanged in both PSO and placebo groups
PSO supplementation improved arterial wave reflection and reduced central hemodynamic load in postmenopausal women with elevated blood pressure
Prostafit is an effective and safe treatment in Benign Prostatic Hyperplasia but not as much as prozasin.
Shirvan MK et al. · JPMA: The Journal of the Pakistan Medical Association (2014)
One hundred patients with BPH were randomly divided into two equal groups receiving prostafit (pumpkin seed oil) and prazosin
International Prostatic Symptom Score had significant differences at baseline and 6 months after treatment in both groups
No complications were observed during and after treatment, and PSA level did not change in either group
18PilotstudieCited 20×n=35 · small study2011
Women receiving pumpkin seed oil showed a significant increase in high density lipoprotein cholesterol concentrations (0.92 ± 0.23 mmol/l vs. 1.07 ± 0.27 mmol/l; p = 0.029) and decrease in diastolic blood pressure (81.1 ± 7.94 mmHg vs. 75.67 ± 11.93 mmHg; p < 0.046).
Gossell-Williams M et al. · Climacteric: The Journal of the International Menopause Society (2011)
Women receiving pumpkin seed oil (2 g/day for 12 weeks) showed a significant increase in HDL cholesterol versus baseline (p = 0.029)
PSO group also showed a significant decrease in diastolic blood pressure (p < 0.046) and improvement in menopausal symptom scores (p < 0.030)
Wheat germ oil placebo group reported being more depressed and having more unloved feelings