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Rei4.0
Reishi – Forschung
Gemischte Evidenz
70 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Reishi half in etwa der Hälfte (2/4) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2026 mit einer typischen Studiengröße von 130 Teilnehmenden.
Basierend auf 70 Studien · 4 Meta-Analysen · 25 RCTs · 6,036 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar1nicht geholfen· 66 weitere ohne bewertete Effektdaten
Nach Outcome
Immune supportVeränderungen von Immunmarkern wurden überwiegend in Labor- und Krebs-Adjuvans-Studien beobachtet · 4-8 weeks
Hilft vermutlich64 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung23 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung9 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung8 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung5 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung5 Studien
Energy & fatigue
Überwiegend Mechanismus / Beobachtung3 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung3 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung3 Studien
Anxiety & stressEine kleine RCT zeigte verbesserten Stress und verbessertes Wohlbefinden · 4-8 weeks · Beruhigende adaptogene Wirkungen; begrenzte Evidenz beim Menschen · 2-4 weeks
Zu wenige bewertete Studien2 Studien
Skin health
Zu wenige bewertete Studien2 Studien
Sleep & insomniaDer Schlafnutzen beruht auf Tierdaten und schwachen Studien am Menschen · 2-4 weeks · Behauptungen zur Entspannung sind weitgehend präklinisch · 2-4 weeks · Ein Nutzen für die Aufrechterhaltung des Schlafs ist beim Menschen nicht belegt · 2-4 weeks
Zu wenige bewertete Studien1 Studie
Men's vitality
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 29 Studien mit messbaren Effekten gezogen
Untersuchte Personen
6,036
typische Studie: 130 Personen
Stärkste Designs
29
4 gepoolt, 25 randomisiert
Zeigte Nutzen
50%
2/4 Studien
Wie lange Studien liefen
1–3 Monate
2
3+ Monate
1
Untersuchte Populationen
Cancer patients5
Autoimmune skin disease patients1
COVID-19 patients1
Global population with COVID-191
Aktives Forschungsgebiet
28 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2020
200420152026
1Identification of immunostimulatory herbal supplementsSystematische Übersichtn=469 · medium study2025
Einfach gesagt: We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
Weiner JD et al. · Lupus science & medicine (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
We identified 227 herbal supplements with immunostimulatory properties, of which 15 were most strongly supported by the evidence.
This article may serve as a reference to help clinicians counsel patients with autoimmune skin diseases on the risks associated with use of specific herbal supplements.
5Longevity and neuroprotective medicine developmentÜbersicht2023
Einfach gesagt: Maitake or hen-of-the-woods), the genus Pleurotus (e.g. oyster mushrooms), and Agaricus subrufescens (i.e. the almond mushroom).
Shevchuk Y et al. · Ageing research reviews (2023)
Maitake or hen-of-the-woods), the genus Pleurotus (e.g. oyster mushrooms), and Agaricus subrufescens (i.e. the almond mushroom).
We propose that further research on fungal extracts will provide a greater picture of the role fungi-derived bioactive molecules can have in developing longevity and neuroprotective medicines for humans.
6Functional food production potentialÜbersicht2023
Einfach gesagt: This review focuses on the properties of selected medicinal mushrooms and their effects on the human organism and presents current knowledge on the possibilities of their use in the production of functional foods.
Łysakowska P et al. · Molecules (Basel, Switzerland) (2023)
Detailed mechanisms of the effects of medicinal mushrooms on the human organism still require long-term clinical studies to confirm their nutraceutical effects, their safety of use, and their dosage.
Medicinal mushrooms have great potential to be used in the design of innovative functional foods.
There is a need for further research on the possibility of incorporating mushrooms into food products to assess the interactions of their bioactive substances with ingredients in the food matrix.
7Combat SARS-CoV-2 infection and co-morbiditiesÜbersicht2023
Einfach gesagt: Preclinical and clinical evaluation to establish dose, efficacy, and potential toxicity and possible use in the management of COVID-19 is recommended.
Rowaiye AB et al. · International journal of medicinal mushrooms (2023)
However, there are concerns about the safety as well as the efficacy of drugs and vaccines presently used to control the pandemic, therefore necessitating intense global search for safe natural products that can effectively and safely combat it.
This work reviews studies on lingzhi or reishi medicinal mushroom, Ganoderma lucidum and its properties that may potentially combat SARS-CoV-2 infection and the co-morbidities.
Preclinical and clinical evaluation to establish dose, efficacy, and potential toxicity and possible use in the management of COVID-19 is recommended.
Einfach gesagt: Among various mushroom species, reishi or lingzhi (Ganoderma lucidum) seem most suitable as anti-COVID agents for the global population.
Rahman MA et al. · International journal of medicinal mushrooms (2021)
In this state-of-the-art review, edible and medicinal mushrooms are featured in the treatment of SARS-CoV-2, COVID-19 pathomanifestations, and comorbid issues.
Because this is not an original research article, we admit our shortcomings in inferences.
Yet we are hopeful that mushroom-based therapeutic approaches can be used to achieve a COVID-free world.
Einfach gesagt: We conclude by emphasizing the need to inform patients and physicians about herb-drug interactions and how to advise patients on appropriate use of herbal supplements to minimize the risk for interactions.
Yeung KS et al. · Oncology (Williston Park, N.Y.) (2018)
Herbs, however, contain biologically active compounds and can potentially interact with prescription medications, including chemotherapy drugs.
We describe the mechanisms via which these interactions may occur, as divided into pharmacokinetics and pharmacodynamics.
We highlight four popular herbs and a medicinal mushroom commonly used by cancer patients-turmeric, green tea, ginger, ashwagandha, and reishi mushroom-along with reports of their interactions with standard drugs.
11Immunomodulating effectsÜbersicht2019
Einfach gesagt: Importantly, evidence-based clinical trials are also needed.
Wang X et al. · Advances in experimental medicine and biology (2019)
In particular, G. lucidum polysaccharides may affect immune cells and immune-related cells including B and T lymphocytes, dendritic cells, macrophages, and natural killer cells, with the promotion of immune organ growth, cytokine release, and other immune regulatory functions.
Furthermore, cellular and molecular immunomodulatory mechanisms, possible receptors involved, and triggered signaling pathways have also been summarized.
However, whole animal experiments are still needed to further establish the mechanism of the immunomodulating effects by Ganoderma.
Sohretoglu D et al. · Anti-cancer agents in medicinal chemistry (2018)
Clinical studies have shown beneficial effects of G. lucidum as an alternative adjuvant therapy in cancer patients without obvious toxicity.
G. lucidum polysaccharides (GLP) is the main bioactive component in the water soluble extracts of this mushroom.
Evidence from in vitro and in vivo studies has demonstrated that GLP possesses potential anticancer activity through immunomodulatory, anti-proliferative, pro-apoptotic, anti-metastatic and anti-angiogenic effects.
13Tumor cell antiproliferative and apoptotic effectsÜbersicht2019
Einfach gesagt: Inhibition against the ATP-dependent transmembrane drug transporter such as P-glycoprotein (P-gp) on the surface of resistant tumor cells to prevent reduction of the intracellular accumulation of anticancer drugs by pumping out the drugs plays an important role in the activities of Ganoderma and its extracts to reverse tumor cell multidrug resistance.
Sun Y et al. · Advances in experimental medicine and biology (2019)
Intrinsic- and extrinsic-initiated apoptotic pathway in association with cell cycle arresting, telomerase inhibiting, autophagy, and oxidative stress is involved in the antiproliferative and apoptosis inductive activities of Ganoderma and its extracts.
The inhibition of tumor cell adhesion, invasion, and migration by Ganoderma and its extracts involves molecular mechanisms such as AP-1, NF-κB, MMP, cadherin, β-integrin, c-Met, FAK, EMT, and so on.
Targeting the major pro-angiogenic stimulus, VEGF, and its receptor contributes to the inhibition of tumor angiogenesis by Ganoderma and its extracts.
14Immune function measures and overall survival in cancer patientsÜbersicht2020
Einfach gesagt: Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
Neuwirthová J et al. · Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2020)
Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
Moreover, they have prolonged their disease-free interval and overall survival.
They are well tolerated even in advanced cancer diseases and could be safely used continuously for long periods of time.
15Protective effects against radiation and chemotherapy side effectsÜbersicht2019
Einfach gesagt: Both basic researches and clinical studies of Ganoderma (Lingzhi) in preventing side effects induced by radiation and chemotherapy were reviewed.
Chen L et al. · Advances in experimental medicine and biology (2019)
But they are also usually associated with some toxicity and side effects in most of the patients.
Ganoderma (Lingzhi) is considered as a major kind of complementary/alternative medicine and used to prevent the adverse effects caused by radiation and chemotherapy.
This chapter reviewed the protective effects of Ganoderma (Lingzhi) on radiation and chemotherapy, including the preventive effects on myelosuppression, intestinal injury, nephrotoxicity, cardiovascular toxicity, and other side effects.
Einfach gesagt: In a more positive vein, the presence of potent toxins and neurotropic compounds in basidiomycete fruit bodies suggests that secondary metabolites with useful pharmacological properties are widespr...
Money NP · Fungal biology (2016)
In a more positive vein, the presence of potent toxins and neurotropic compounds in basidiomycete fruit bodies suggests that secondary metabolites with useful pharmacological properties are widespread in these fungi.
Major investment in controlled experiments and objective clinical trials is necessary to develop this natural pharmacopeia.
18Antitumor and immunomodulatory activities of GSPÜbersicht2019
Einfach gesagt: In this study, we will review the biological activities and preclinical studies of GSP in China based on literatures searches from CNKI (China National Knowledge Infrastructure), VIP (Chongqing VIP...
Zhang Y et al. · Progress in molecular biology and translational science (2019)
In this study, we will review the biological activities and preclinical studies of GSP in China based on literatures searches from CNKI (China National Knowledge Infrastructure), VIP (Chongqing VIP Chinese Scientific Journals Database), Wanfang database, and PubMed database.
Both basic and preclinical studies showed that GSP has antitumor, antioxidant, anticytopenia, and unique mushroom-poison detoxification properties that are different from that of GLPS.
Our goal is to provide a molecular picture that would allow in-depth evaluation of GSP as one of few glycan-based drugs that has been used as an immunomodulatory adjunctive drug during cancer therapy.
Einfach gesagt: In this chapter, we will summarize and elucidate recent progress of such effects of Ganoderma and its ingredients from both the preclinical and clinical points of view.
Cui X et al. · Advances in experimental medicine and biology (2019)
The neuropharmacological effects of G. lucidum mainly include but not limited to sedative and hypnotic, neuroprotective, antinociceptive and analgesic, antiepileptic, and antidepressant effects.
Clinical trials of G. lucidum in the patients with these disorders are still rare.
To date, there are no Ganoderma-related drugs approved by the US Food and Drug Administration (FDA).