Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren
Rtl5.0
Retinol – Forschung
Überwiegend Mechanismus / Beobachtung
13 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Retinol sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1996–2026 mit einer typischen Studiengröße von 51 Teilnehmenden.
Basierend auf 13 Studien · 1 Meta-Analyse · 5 RCTs · 2,119 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Skin healthModerate Reduktion feiner Linien und des Erscheinungsbilds von Photoaging (kosmetisch, kein gesundheitlicher Endpunkt) · 12-24 weeks · Kann das Erscheinungsbild von Festigkeit/Elastizität durch Prokollagen-Induktion verbessern (kosmetisch, formulierungsabhängig) · 12-24 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Micronutrient & trace-element status
Zu wenige bewertete Studien2 Studien
Lean body mass & muscle growth
Zu wenige bewertete Studien1 Studie
Endurance & exercise performance
Zu wenige bewertete Studien1 Studie
Anemia & hematology
Zu wenige bewertete Studien1 Studie
Weight management
Zu wenige bewertete Studien1 Studie
Skin tone & pigmentationModerate Verbesserung von Hyperpigmentierung/Hautton, überwiegend als sekundärer Endpunkt in Studien zu Photoschäden (kosmetisch) · 8-24 weeks
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
8 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199620112026
1Systematische Übersicht2026
Circulating SAA and its cargo might be an important contributor to gut-liver axis in ALD.
Zhong W et al. · Alcohol (Fayetteville, N.Y.) (2026)
Some of the functions of SAA are tightly associated with its role in acute phase HDL.
In ALD, SAA has important functions both in the liver, where it promotes inflammation and regeneration and repair after alcohol cessation, and in the intestine, where it induces T-cell differentiation, and promotes phagocytosis of Gram-negative bacteria.
Circulating SAA and its cargo might be an important contributor to gut-liver axis in ALD.
2Systematische Übersichtn=16 · very small study2026
However, inconsistent results highlight the need for larger, standardized trials to clarify exercise modality-specific effects.
Alsahafi Z et al. · Physiological research (2026)
Aerobic and combined aerobic-resistance exercise were associated with significant reductions in circulating RBP4 levels among obese and T2DM groups, whereas results in healthy individuals remained inconsistent.
In contrast, single-session and endurance training interventions did not produce significant effects.
Exercise training demonstrates potential to lower circulating RBP4, particularly in metabolically compromised populations.
Using EHFP to deliver WASH and SQ-LNS reduced child anemia and improved micronutrient status.
Bliznashka L et al. · The Journal of nutrition (2026)
Adding WASH (groups 1 compared with 2) reduced anemia [hemoglobin (Hb) <11 g/dL] (DID = 9.43 pp, P < 0.01) and led to a decline in weight-for-age Z-score (DID -0.11 ± 0.04, P = 0.01).
Adding SQ-LNS (groups 3 compared with 4) increased Hb (DID = 0.26 ± 0.13 g/dL, P < 0.05), plasma ferritin (DID = 7.61 ± 2.69 μg/L, P < 0.01), and retinol binding protein (DID = 0.07 ± 0.02 μmol/L, P < 0.01) concentrations.
Using EHFP to deliver WASH and SQ-LNS reduced child anemia and improved micronutrient status.
Home enteral nutrition attenuated weight loss and contributed to improved short-term nutritional status during the first 3 months after oesophagectomy.
Shiraishi O et al. · Clinical nutrition ESPEN (2026)
In the intention-to-treat population, the percentage change in BMI at 3 months was significantly smaller in the EN group than in the OI group (-6.8% vs -10.9%; mean difference 4.1%, 95% CI 0.8-7.4; P = 0.015).
After excluding protocol discontinuations, 51 patients (EN, n = 27; OI, n = 24) were analysed in the protocol-defined evaluable population, with consistent results (mean difference 4.7%, 95% CI 1.1-8.3; P = 0.012).
The EN group tended to show a smaller decrease in body fat mass (-9.5% vs -18.3%; P = 0.189), while experiencing a comparable loss of skeletal muscle mass (-14.4% vs -17.5%; P = 0.475).
Topical retinol improves fine wrinkles associated with natural aging.
Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S. · Arch Dermatol (2007)
Randomized, double-blind, vehicle-controlled left/right-arm study: 0.4% retinol lotion vs vehicle applied up to 3x/week for 24 weeks in 36 elderly subjects (mean age 87)
Significant reduction in fine wrinkling scores for retinol vs vehicle (-1.64 [95% CI -2.06 to -1.22] vs -0.08 [95% CI -0.17 to 0.01]; P<.001)
Retinol significantly increased glycosaminoglycan expression (P=.02) and procollagen I immunostaining (P=.049) vs vehicle, linking the clinical effect to matrix synthesis
Bayesian network meta-analysis showed isotretinoin, retinol, and tretinoin significantly improved fine wrinkles, with isotretinoin ranked highest.
Lin L, Chen X, Liu C, Wang Q, Lian W, Xu X, Guo Y, Zhong H, Zhong J, Zhao N, Cheng W, Shu P, Xu Z. · Sci Rep (2025)
Systematic review and Bayesian network meta-analysis of 23 RCTs (3905 participants) of topical anti-photoaging agents
Retinol significantly improved fine wrinkles (alongside isotretinoin and tretinoin), and retinol and tretinoin were superior for hyperpigmentation
Retinol ranked below the prescription retinoids for fine wrinkles; limitations included limited racial diversity, potential commercial bias, and assessment variability
There is very little, if any, trustworthy evidence available to support the use of over-the-counter cosmetic retinol-containing products to improve the appearance of aged skin.
Spierings NMK. · J Clin Aesthet Dermatol (2021)
Systematic review of 9 randomized, double-blind, vehicle-controlled trials of OTC retinol products for facial skin aging
Four of nine trials reported no statistically significant difference between retinol and vehicle; the five 'positive' trials showed only weak evidence of a mild effect on fine wrinkles
All five positive trials had major methodological flaws calling their validity into question — the key counter-evidence on this page
9RCTn=64 · small study2009
After eight weeks, the retinol moisturizer was significantly more efficacious than the vehicle in improving lines and wrinkles, pigmentation, elasticity, firmness and overall photodamage.
Eight-week, double-blind, split-face, randomized study: stabilized 0.1% retinol moisturizer (36 subjects) vs vehicle (28 subjects) in women with moderate facial photodamage
Retinol significantly outperformed vehicle on lines/wrinkles, pigmentation, elasticity, firmness, and overall photodamage on a 0-9 scale at 8 weeks
Many differences were already significant at week 4 with progressive improvement to week 8; reported as safe
10Open-Labeln=218 · medium study2022
Fibrillin-rich microfibril deposition was increased following treatment with 0.3% and 1% retinol (p < 0.01); other dermal components remained unaltered.
Mellody KT, Bradley EJ, Mambwe B, Cotterell LF, Kiss O, Halai P, Loftus Z, Bell M, Griffiths TW, Griffiths CEM, Watson REB. · Int J Cosmet Sci (2022)
In-vivo patch-test biopsy study (photoaged forearm, 12 days) plus a six-week daily-use tolerability study (n=218) of 0.3% vs 1% retinol
Retinol increased epidermal thickness, stratum-corneum proteins (filaggrin, KPRP), keratinocyte proliferation, and fibrillin-rich microfibril deposition (p<0.01) — but fibronectin, collagen fibrils, and elastin were unchanged
0.3% retinol was significantly better tolerated than 1% with fewer/milder adverse events (p<0.001)
Although improvements with the 0.5% retinol were more modest, side effects such as burning, dryness, pruritus, and erythema during the 8-week study period were minimal.
Includes a randomized, double-blind, vehicle-controlled arm (n=30) over 8 weeks for facial photodamage, plus an open-label 1% retinol pilot
1% retinol improved photodamaged skin over 8-12 weeks; improvements with 0.5% retinol were modest, attributed to the lower concentration
Tolerability was good at 0.5% (minimal burning, pruritus, dryness, erythema), illustrating the efficacy-vs-irritation tradeoff with retinol dose
12In vitro2000
Pretreatment of human skin in vivo with all-trans retinoic acid inhibits UV induction of c-Jun and protects skin against loss of procollagen synthesis.
Fisher GJ, Datta S, Wang Z, Li XY, Quan T, Chung JH, Kang S, Voorhees JJ. · J Clin Invest (2000)
In human skin, a single UV exposure substantially reduces type I and type III procollagen synthesis within 24 hours, even at sub-erythemal doses
Retinoic acid pretreatment inhibits UV-induced c-Jun and protects against the loss of procollagen synthesis
Establishes the foundational mechanism by which retinoids (the active form retinol converts to) counter photoaging at the collagen level
Human skin study of topical retinol; confirms retinol is metabolised to retinoic acid via a tightly controlled two-step conversion, but only a small fraction of applied retinol is converted