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Saf7.5
Saffron – Forschung
Hilft wahrscheinlich
82 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Saffron scheint in 9 von 10 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2026 mit einer typischen Studiengröße von 66 Teilnehmenden.
Basierend auf 82 Studien · 19 Meta-Analysen · 18 RCTs · 26,086 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
9geholfen1unklar· 72 weitere ohne bewertete Effektdaten
Neuroprotection & brain agingCrocin zeigt neuroprotektive Wirkungen in Studien zum kognitiven Altern · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung14 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung11 Studien
Inflammation
Überwiegend Mechanismus / Beobachtung9 Studien
Cognitive functionNeuroprotektives Crocin unterstützt Lernen und Gedächtnis · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung7 Studien
Women's healthKann helfen, Menstruationsbeschwerden und PMS-Symptome zu reduzieren · 1-3 Zyklen
Überwiegend Mechanismus / Beobachtung6 Studien
Sleep & insomniaModerate Verbesserung des Schlafs · 4 Wochen · Crocin und Safranal fördern Entspannung und Einschlafen · 2-4 Wochen
Überwiegend Mechanismus / Beobachtung5 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung5 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung4 Studien
Men's vitality
Überwiegend Mechanismus / Beobachtung3 Studien
Vision & eye healthCrocin schützt Netzhautzellen und verbessert die Sehfunktion · 4-8 Wochen
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Weight management
Zu wenige bewertete Studien2 Studien
Focus & attentionVerbessert Aufmerksamkeit und Verarbeitungsgeschwindigkeit in klinischen Studien · 4-8 Wochen
Zu wenige bewertete Studien2 Studien
In Zahlen
Aus 58 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
63%
über Studien hinweg
Untersuchte Personen
26k
typische Studie: 66 Personen
Stärkste Designs
37
19 gepoolt, 18 randomisiert
Zeigte Nutzen
90%
9/10 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
4
3+ Monate
1
Untersuchte Populationen
Various patient populations3
Patients with depression and anxiety2
Adults with mild-to-moderate depression2
General population2
Aktives Forschungsgebiet
69 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200420152026
1Depressive disorder symptomsMeta-AnalyseCited 1×n=17,437 · very large study2025
This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
Cheng YC et al. · Psychological medicine (2025)
Adjunctive nutraceuticals consistently showed better efficacy than antidepressants (ADT) alone in outcomes including SMD, remission, and response.
This extensive systematic review and NMA of nutraceuticals for treating depressive disorders indicated a number of nutraceuticals that could offer benefits, either as adjuncts or monotherapies.
2ADHD symptomsSystematische ÜbersichtCited 3×n=118 · medium study2024
The results manifested an efficient role of saffron as either an adjuvant therapy to MPH or a single therapy against ADHD, without significant safety issues.
Seyedi-Sahebari S et al. · Journal of attention disorders (2024)
Future longer follow-up, larger samples, and more methodologically rigorous randomized controlled trials are recommended to clearly establish the effects of different dosages on cognitive function and quality of life in stroke patients.
Li J et al. · Phytotherapy research : PTR (2025)
John's Wort extract (SUCRA 71.2%) was the most effective in reducing NIHSS scores, Berberine (SUCRA 84.1%) was most effective in reducing mRS scores, and St.
John's Wort extract (SUCRA 99.1%) showed the highest efficacy in enhancing ADL scores.
Ginsenosides were the most effective in improving Barthel Index (SUCRA 74.7%), MMSE (SUCRA 93%), and MOCA (SUCRA 79.7%) scores.
Only ginger and black cumin reported a significant improvement in glycated hemoglobin, and only cinnamon and ginger showed a significant decrease in insulin.
Garza MC et al. · Nutrients (2024)
Our results showed that cinnamon, turmeric, ginger, black cumin, and saffron significantly improved the fasting glucose levels in T2DM subjects.
The most significant decreases in fasting glucose were achieved after supplementation with black cumin, followed by cinnamon and ginger, which achieved a decrease of between 27 and 17 mg/dL.
Only ginger and black cumin reported a significant improvement in glycated hemoglobin, and only cinnamon and ginger showed a significant decrease in insulin.
5Systematische ÜbersichtCited 2×n=50 · small study2024
This review concluded that C. sativus can improve the symptoms of several female reproductive system disorders, which is particularly due to the presence of phytochemical ingredients, such as crocin, crocetin, and safranal.
Hasheminasab FS et al. · Phytotherapy research : PTR (2024)
These studies confirmed the efficacy of C. sativus or its main phytochemical ingredients in several aspects of the female reproductive system, including regulation of sex hormones, folliculogenesis, ovulation, and protection of the ovary and uterus against several oxidative stress.
Several retrieved studies indicated that this herb also can alleviate the symptoms of patients suffering from dysmenorrhea, premenstrual syndrome, menopause, polycystic ovary disease (PCOD), and sexual dysfunction.
Furthermore, it is a promising candidate for future studies or even trials regarding ovarian and cervical cancers.
Findings from clinical trials conducted to date indicate that saffron supplementation can improve symptoms of depression in adults with MDD.
Hausenblas HA et al. · Journal of integrative medicine (2013)
A large effect size was found for saffron supplementation vs placebo control in treating depressive symptoms (M ES = 1.62, P < 0.001).
A null effect size was evidenced between saffron supplementation and the antidepressant groups (M ES = -0.15) indicating that both treatments were similarly effective in reducing depression symptoms.
Based on our pre-specified criteria, five randomized controlled trials (n = 2 placebo controlled trials, n = 3 antidepressant controlled trials) were included in our review.
7Depression and anxiety symptomsMeta-AnalyseCited 12×2025
Saffron could be a potential SSRI alternative to reduce depressive and anxiety symptoms with fewer adverse events.
Shafiee A et al. · Nutrition reviews (2025)
Saffron could be a potential SSRI alternative to reduce depressive and anxiety symptoms with fewer adverse events.
Further research with larger sample sizes and in diverse populations is warranted to validate these findings and explore potential moderators of treatment response.
8Insomnia improvementMeta-AnalyseCited 8×n=431 · medium study2022
This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative-hypnotic medication, thus reducing dependency and withdrawal symptoms.
Munirah MP et al. · International journal of environmental research and public health (2022)
Eight articles were included, involving 431 participants.
Although there is limited evidence of a very low- to moderate-quality, Crocus sativus may benefit people with insomnia.
This non-pharmacological intervention may reduce the chance of adults with insomnia taking sedative-hypnotic medication, thus reducing dependency and withdrawal symptoms.
Further high-quality studies should be conducted to establish the clinical efficacy of herbal medicines.
Correia AGDS et al. · Phytotherapy research : PTR (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Could be chance
The mean difference (MD) and the standardized MD (SMD) were adopted, and subgroup analyses were performed according to patient's clinical condition.
Saffron supplementation reduced FBG (MD: -9.06 mg/dl; 95%CI: -16.25 to -1.86; I2 = 40%; p = 0.12) and HbA1c (MD: -0.19%; 95%CI: -0.23 to -0.14; I2 = 0%; p > 0.99).
Our results show that using saffron and fenugreek can reduce FBG, PPBG, and HbA1c; however, there are some shortcomings that require attention for these results.
Saffron may exert protective roles for neurological and psychiatric disorders and represents a relatively favorable and safe treatment.
Han S et al. · Phytotherapy research : PTR (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
A random-effects or fixed-effects model was used to calculate the pooled effect sizes.
Saffron was more effective than placebo in improving cognition, depression with an overall effect size of -4.26 (95% CI: -5.76, -2.77), anxiety of -3.75 (95% CI: -5.83, -1.67), and sleep disorders of -1.91 (95% CI: -2.88, -0.93).
Forty-six RCTs were enrolled, and the duration of these trials ranged from 4 to 48 weeks with saffron or its extracts, both alone or in combination with conventional drugs.
Saffron and its major constituents employ anti-inflammatory, anti-apoptotic and antioxidant mechanisms in modulating several dysregulated-signaling pathways in NDDs.
Abdian S et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2024)
Saffron and its major constituents employ anti-inflammatory, anti-apoptotic and antioxidant mechanisms in modulating several dysregulated-signaling pathways in NDDs.
However, further research is necessary to elucidate the precise underlying mechanisms in exploring the feasibility of using saffron active compounds against NDDs.
More studies should focus on dose-response relationships, long-term effects, highlighting key mechanisms, and designing more well-controlled clinical trials.
Data analysis showed that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD.
Moreover, combination of natural and pharmaceuticals has far better effects than only allopathic treatment.
Thus, different herbal remedies in combination with FDA approved drugs are effective and more promising in treatment of AD.
14Treatment recommendations for nutraceuticals and phytoceuticals in psychiatric disordersMeta-AnalyseCited 117×2022
Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders.
Sarris J et al. · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2022)
Based on the current data and clinician input, a range of nutraceuticals and phytoceuticals were given either a supportive recommendation or a provisional recommendation across a range of various psychiatric disorders.
However several had only a weak endorsement for potential use; for a few it was not possible to reach a clear recommendation direction, largely due to mixed study findings; while some other agents showed no obvious therapeutic benefit and were clearly not recommended for use.
It is the intention of these guidelines to inform psychiatric/medical, and health professional practice globally.
15Anxiety symptoms (HAMA scores)Meta-AnalyseCited 48×n=29 · very small study2022
Medicinal herbs may be promising for the treatment of anxiety.
Zhang W et al. · Pharmacological research (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Kava was found to be an effective anxiolytic (MD: -2.46, 95% CrI: -4.47 to -0.32) but possibly ineffective in patients with generalized anxiety disorder (MD: -0.17, 95% CrI: -2.55 to -1.97).
Ginkgo biloba (MD: -4.63, 95% CrI: -9.01 to -0.23) and Withania somnifera (MD: -4.90, 95% CrI: -9.70 to -0.17) were efficacious, as measured by HAMA scores but the trials were limited by their small sample sizes.
Conversely, although Passionflower (MD: -4.20, 95% CrI: -8.82 to 0.16) and Saffron (MD: -2.71, 95% CrI: -6.06 to 0.57) did not reduce HAMA scores significantly in the summary network, both were worthy of further study because of support from separate networks.
Despite bearing several limitations, mainly as a result of heterogeneity among included studies, the available evidence indicates saffron supplementation shows promising effects on some cardiometabolic factors among overweight to obese patients; however, further investigations and high-quality evidence are required for more generalizable and comprehensive results.
Tahmasbi F et al. · Phytotherapy research : PTR (2022)
A random-effects meta-analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results.
Further high-quality studies are needed to firmly establish the clinical efficacy of supplemental saffron on inflammatory biomarkers.
Asbaghi O et al. · Phytotherapy research : PTR (2021)
Subgroup analysis indicated a significant reduction in serum CRP levels in studies with baseline CRP of ≥3 mg/L, saffron dosage of ≤30 mg/day, and intervention duration of <12 weeks, as well as trials that used crocin.
Similarly, saffron was found to decrease TNF-α in studies that recruited non-diabetic subjects, subjects with baseline levels of ≥15 pg/mL, and participants with <50 years old, as well as trials that administered saffron at the dosage of ≤30 mg/day.
We also found a significant non-linear effect of saffron dosage on serum CRP concentrations (pnon-linearity = .03).
This study suggests that saffron and crocin may modulate the serum lipid profile in patient with metabolic disorders.
Roshanravan B et al. · Archives of physiology and biochemistry (2022)
A pooled analysis using a model for random-effects showed that HDL-C levels were 0.21 fold higher in the saffron and 0.01 fold higher in the crocin group than placebo.
LDL-C levels in the saffron group reduced by 0.51 and 0.04 fold in the crocin group versus the placebo.
Moreover, TC levels in the saffron group were 0.19 lower and 0.11 fold lower in crocin group than in the placebo group.
19Oxidative stress reduction in diabetesSystematische ÜbersichtCited 17×2022
Most studies have shown that saffron supplementation significantly enhanced the production and activity of antioxidant enzymes and decreased oxidative stress indices in diabetes mellitus.
Moini Jazani A et al. · Clinical nutrition ESPEN (2022)
Most studies have shown that saffron supplementation significantly enhanced the production and activity of antioxidant enzymes and decreased oxidative stress indices in diabetes mellitus.
However, human pharmacokinetic and more accurate clinical trial studies are needed to determine dose ranges and the exact mechanisms of action of saffron and its active components in diabetes.