Wir verwenden standardmäßig essenzielle Cookies (Anmeldung, deine gespeicherten Ziele/Stacks). Mit deiner Erlaubnis aktivieren wir außerdem datenschutzfreundliche Analytik (Vercel Web Analytics, anonyme Ladezeit-Metriken) und Fehler-Replay-Diagnostik (Sentry — DOM-Snapshots nur, wenn ein Fehler auftritt), damit wir Bugs schneller beheben können. Mehr über Cookies erfahren

SGE6.0

Sage – Forschung

Überwiegend Mechanismus / Beobachtung

27 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Sage sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2003–2026 mit einer typischen Studiengröße von 71 Teilnehmenden.

Basierend auf 27 Studien · 3 Meta-Analysen · 16 RCTs · 1,006 Teilnehmende insgesamt

Konfidenz

Hohe Konfidenz

Was die Studien gefunden haben

2geholfen· 25 weitere ohne bewertete Effektdaten

Nach Outcome

Cognitive functionHemmt die Acetylcholinesterase, um die Gedächtniskonsolidierung und den Abruf zu verbessern; mehrere RCTs zeigen signifikante Verbesserungen der kognitiven Leistungsfähigkeit · 2-4 weeks
Überwiegend Mechanismus / Beobachtung24 Studien
Women's healthReduziert Häufigkeit und Schweregrad von Hitzewallungen um bis zu 50 % durch östrogene Aktivität an ERα-/ERβ-Rezeptoren · 4-8 weeks · Phytoöstrogene binden an ERα/ERβ zur Unterstützung des Östrogengleichgewichts während der Perimenopause und Menopause · 4-8 weeks
Überwiegend Mechanismus / Beobachtung10 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung7 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung4 Studien
InflammationHemmt COX-2- und NF-kB-Signalwege über Rosmarinsäure und Carnosinsäure · 4-8 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Anxiety & stressModuliert GABAerge und serotonerge Signalwege zur Verringerung leichter Angstsymptome · 2-4 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Depression & moodUnterstützt die Stimmungsstabilität durch Cholinesterasehemmung und entzündungshemmende Wirkungen · 4-8 weeks
Zu wenige bewertete Studien1 Studie
Neuroprotection & brain agingCholinerg + antioxidativ; untersucht in Alzheimer-Kohorten · 8-12 weeks
Zu wenige bewertete Studien1 Studie
Endurance & exercise performance
Zu wenige bewertete Studien1 Studie
Sleep & insomnia
Zu wenige bewertete Studien1 Studie

In Zahlen

Aus 16 Studien mit messbaren Effekten gezogen

Wahrscheinlich echte Effekte

100%

über Studien hinweg

Untersuchte Personen

1,006

typische Studie: 71 Personen

Stärkste Designs

3 gepoolt, 16 randomisiert

Zeigte Nutzen

100%

2/2 Studien

Wie lange Studien liefen

Unter einer Woche

1–4 Wochen

1–3 Monate

3+ Monate

Untersuchte Populationen

Postmenopausal women2

Type 2 diabetic patients2

Women with metabolic syndrome1

Overweight/obese women1

Aktives Forschungsgebiet

11 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2023

200320142026

1Meta-Analyse2023

Moradi M, Ghavami V, Niazi A, Seraj Shirvan F, Rasa S · Int J Community Based Nurs Midwifery (2023)

Quelle ansehen

2Systematische Übersicht2014

Miroddi M, Navarra M, Quattropani MC, Calapai F, Gangemi S, Calapai G · CNS Neurosci Ther (2014)

Quelle ansehen Kostenloser Volltext

3Chronic inflammation and quality of lifeÜbersichtn=124 · medium study2026

Einfach gesagt: This review provides up-to-date information for further basic and clinical research on herbal medicine in metabolic syndrome.

Winiarska A et al. · Nutrients (2026)

Incorporating spice herbs into the daily diet may represent a simple and safe approach to increasing the intake of anti-inflammatory bioactive compounds.
Conclusions: Future research should focus on the precise determination of optimal doses and combinations of spice herbs to maximise benefits while avoiding potential adverse effects resulting from excessive intake of certain compounds or inappropriate selection of spice herbs.
Long-term studies conducted in larger populations of women with metabolic syndrome are required, as physiological differences, particularly those related to oestrogens, may result in sex-specific effects.

Quelle ansehen

4RCT2025

Maleki-Hajiagha A, Mojab F, Amidi F, Amini L · BMC Complement Med Ther (2025)

Quelle ansehen Kostenloser Volltext

5RCT2020

Amini L, Mojab F, Jahanfar S, Sepidarkish M, Raoofi Z, Maleki-Hajiagha A · Complement Ther Med (2020)

Quelle ansehen

6RCT2018

Perry NSL, Menzies R, Hodgson F, Wedgewood P, Howes MR, Brooker HJ · Phytomedicine (2018)

Quelle ansehen

7RCT2019

Abdnezhad R, Simbar M, Sheikhan Z, Mojab F, Nasiri M · Complement Med Res (2019)

Quelle ansehen

8RCT2013

Kianbakht S, Dabaghian FH · Complement Ther Med (2013)

Quelle ansehen

9RCT2008

Scholey AB, Tildesley NT, Ballard CG, Wesnes KA, Tasker A, Perry EK · Psychopharmacology (Berl) (2008)

Quelle ansehen

10RCT2021

Wightman EL, Jackson PA, Spittlehouse B, Heffernan T, Guillemet D, Kennedy DO · Nutrients (2021)

Quelle ansehen Kostenloser Volltext

11RCT2011

Kennedy DO, Dodd FL, Robertson BC, Okello EJ, Reay JL, Scholey AB · J Psychopharmacol (2011)

Quelle ansehen

12Systematische Übersicht2026

Einfach gesagt: A study among overweight/obese (mean BMI = 27 kg/m2) women provided with dietary red pepper and turmeric for 4 weeks demonstrated that these spices did not affect oxidative stress or inflammatory markers compared to a placebo, and another study showed that black pepper did not affect 24-hour energy expenditure or substrate utilization among postmenopausal women when provided at 0.5 mg/meal.© The Author(s) 2026.

Johnson GH · Nutrition reviews (2026)

A study among cafeteria patrons reported similar appreciation for a LS legume-based mezze with herbs and spices and its counterpart with 50% higher salt, suggesting that the addition of herbs and spices is a feasible strategy to reduce salt content while maintaining consumer acceptance.
Published in Nutrition reviews (2026)
Further research warranted to confirm findings

Quelle ansehen

13Hot flash frequencyMeta-Analysen=310 · medium study2023

Einfach gesagt: Sage significantly reduced hot flash frequency in postmenopausal women compared to placebo

Moradi M et al. · Int J Community Based Nurs Midwifery (2023)

Meta-analysis of 4 studies with 310 participants
All 4 studies showed sage reduced hot flash frequency and severity
Significant reduction in hot flash frequency vs placebo

14Fasting blood sugarMeta-Analyse2022

Einfach gesagt: The results of meta-analysis showed that S. officinalis reduced fasting blood sugar (FBS) (mg/dL) (MD: -31.15; 95% CI: -37.56 to -24.73; p<0.00001). It also reduced HbA1c (%) (MD: -0.94; 95% CI: -1.25 to -0.63; p<0.00001).

Abdollahi A et al. · J Complement Integr Med (2022)

Spürbar Nutzen

← SchlechterKein EffektBesser →

Likely real

Meta-analysis of 3 RCTs on sage in diabetes
Significant reduction in FBS (MD: -31.15 mg/dL, P<0.00001)
Significant reduction in HbA1c (MD: -0.94%, P<0.00001)

Quelle ansehen

15Anxiety and mood measuresRCTn=30 · small study2006

Einfach gesagt: 300 mg sage reduced anxiety; 600 mg increased alertness, calmness and contentedness

Kennedy DO et al. · Neuropsychopharmacology (2006)

Double-blind crossover study in 30 healthy participants
300 mg dose significantly reduced anxiety on STAI
600 mg dose significantly increased alertness and contentedness

Quelle ansehen Kostenloser Volltext

16Ethnobotanical uses of Salvia speciesÜbersicht2026

Einfach gesagt: Ethnopharmacological evidence revealed 187 Salvia species with documented uses across Asia (Middle East, China), America (Mesoamerica and South America), Africa (Saharan and southern regions), and Europe (Mediterranean and Balkan areas).

Nicolescu A et al. · Journal of ethnopharmacology (2026)

Ethnopharmacological evidence revealed 187 Salvia species with documented uses across Asia (Middle East, China), America (Mesoamerica and South America), Africa (Saharan and southern regions), and Europe (Mediterranean and Balkan areas).
The most frequently cited ailments in which Salvia species are used were gastrointestinal (127), respiratory (86), dermatological (82), and genitourinary (80).
Culinarily, the genus provides aromatic and nutritional properties, increasing the value of diverse dishes and beverages.

Quelle ansehen

17Menopausal symptomsRCTn=80 · small study2021

Einfach gesagt: Salvia off. within 4 weeks significantly reduced the somato-vegetative (e.g. hot flushes) and psychological MRS subscale (e.g. physical and mental exhaustion) subscale (p < 0.05) without a significant effect on the genito-urinary subscale.

Wilfried D, Nina CDG, Silvia B · Heliyon (2021)

Double-blind RCT in 80 menopausal women aged 48-65
Significant reduction in hot flushes, exhaustion, and fatigue
Improved sleep quality (PSQI) and mood (POMS)

Quelle ansehen Kostenloser Volltext

18ADAS-cog and CDR-SB scoresRCTn=42 · small study2003

Einfach gesagt: Sage extract produced significantly better cognitive outcomes than placebo in mild-to-moderate Alzheimer's disease at 4 months

Akhondzadeh S et al. · J Clin Pharm Ther (2003)

Likely real

Significant improvement in ADAS-cog and CDR-SB scores vs placebo (P<0.003)
Reduced agitation in the treatment group
No significant side effect differences between groups

Quelle ansehen

19Lipid profile improvementRCTn=67 · small study2011

Einfach gesagt: Sage extract significantly lowered total cholesterol, triglycerides, LDL, and VLDL while increasing HDL

Kianbakht S et al. · Phytother Res (2011)

Double-blind RCT in 67 hyperlipidemic patients
500 mg sage extract every 8 hours for 2 months
Significant reductions in TC, TG, LDL, and VLDL

Quelle ansehen

20Memory, attention, alertness, and moodÜbersicht2017

Einfach gesagt: Multiple human trials confirm improvements in memory, attention, alertness, and mood following sage administration

Lopresti AL · Drugs R D (2017)

Comprehensive review of Salvia cognitive effects
Key mechanisms: AChE inhibition, antioxidant, anti-inflammatory, estrogenic activity
Multiple RCTs confirm memory and mood benefits

Quelle ansehen Kostenloser Volltext

In der Forschungsbibliothek ansehen

Sage – Forschung

Überwiegend Mechanismus / Beobachtung

In Zahlen

The Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis.

Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.

The Use of Spice Herbs May Reduce Chronic Inflammation and Improve the Quality of Life of Women with Metabolic Syndrome-A Narrative Review

Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.

Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical trial.

A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age.

[Salvia officinalis Reduces the Severity of the Premenstrual Syndrome].

Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial.

An extract of Salvia (sage) with anticholinesterase properties improves memory and attention in healthy older volunteers.

The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans.

Monoterpenoid extract of sage (Salvia lavandulaefolia) with cholinesterase inhibiting properties improves cognitive performance and mood in healthy adults.

Exploratory Studies on the Potential Health Benefits of Spices and Herbs

Effect of Salvia Officinalis on Hot Flashes in Postmenopausal Women: A Systematic Review and Meta-Analysis

The effect of Salvia officinalis on blood glycemic indexes and blood lipid profile in diabetic patients: a systematic review and meta-analysis

Effects of cholinesterase inhibiting sage on mood, anxiety and performance on a psychological stressor battery

Ethnobotanical diversity of the genus Salvia L. (Lamiaceae): From medicinal and culinary applications to cultural importance of sage species across the globe

Effectiveness of Menosan® Salvia officinalis in the treatment of a wide spectrum of menopausal complaints. A double-blind, randomized, placebo-controlled, clinical trial

Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease

Antihyperlipidemic effects of Salvia officinalis L. leaf extract in patients with hyperlipidemia

Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects