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SGE6.0
Sage – Forschung
Überwiegend Mechanismus / Beobachtung
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Sage sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2003–2026 mit einer typischen Studiengröße von 66 Teilnehmenden.
Basierend auf 23 Studien · 2 Meta-Analysen · 13 RCTs · 1,305 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen· 21 weitere ohne bewertete Effektdaten
Nach Outcome
Cognitive functionHemmt die Acetylcholinesterase, um die Gedächtniskonsolidierung und den Abruf zu verbessern; mehrere RCTs zeigen signifikante Verbesserungen der kognitiven Leistungsfähigkeit · 2-4 weeks
Überwiegend Mechanismus / Beobachtung18 Studien
Women's healthReduziert Häufigkeit und Schweregrad von Hitzewallungen um bis zu 50 % durch östrogene Aktivität an ERα-/ERβ-Rezeptoren · 4-8 weeks · Phytoöstrogene binden an ERα/ERβ zur Unterstützung des Östrogengleichgewichts während der Perimenopause und Menopause · 4-8 weeks
Überwiegend Mechanismus / Beobachtung9 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung6 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung5 Studien
InflammationHemmt COX-2- und NF-kB-Signalwege über Rosmarinsäure und Carnosinsäure · 4-8 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Anxiety & stressModuliert GABAerge und serotonerge Signalwege zur Verringerung leichter Angstsymptome · 2-4 weeks
Überwiegend Mechanismus / Beobachtung3 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Depression & moodUnterstützt die Stimmungsstabilität durch Cholinesterasehemmung und entzündungshemmende Wirkungen · 4-8 weeks
11 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2023
200320142026
1Chronic inflammation and quality of lifeSystematische Übersichtn=124 · medium study2026
This review provides up-to-date information for further basic and clinical research on herbal medicine in metabolic syndrome.
Winiarska A et al. · Nutrients (2026)
Incorporating spice herbs into the daily diet may represent a simple and safe approach to increasing the intake of anti-inflammatory bioactive compounds.
Conclusions: Future research should focus on the precise determination of optimal doses and combinations of spice herbs to maximise benefits while avoiding potential adverse effects resulting from excessive intake of certain compounds or inappropriate selection of spice herbs.
Long-term studies conducted in larger populations of women with metabolic syndrome are required, as physiological differences, particularly those related to oestrogens, may result in sex-specific effects.
Factors found to be associated with vaccination intention vs. uptake were inconsistent, though these findings should be interpreted cautiously given the modest number of studies addressing this issue.
Khudair M et al. · Human vaccines & immunotherapeutics (2026)
We identified 222 qualitative factors from 32 studies, and 114 quantitative factors from 30 studies.
Qualitative studies frequently reported individual and group influences, particularly beliefs and attitudes about vaccine effectiveness and safety, and the role of healthcare professionals in decision-making.
Quantitative studies highlighted sociodemographic influences, including older age, ethnicity, and lower social/economic deprivation.
A study among cafeteria patrons reported similar appreciation for a LS legume-based mezze with herbs and spices and its counterpart with 50% higher salt, suggesting that the addition of herbs and spices is a feasible strategy to reduce salt content while maintaining consumer acceptance.
These recommendations provide theoretical support and practical insights for visualization design research that considers age-related perception of spatial frequency.
Shao S et al. · IEEE transactions on visualization and computer graphics (2026)
After rigorous screening, 33 studies were included and evaluated, with their similarities and differences compared across five dimensions.
Cluster analysis further categorizes the literature into five groups, confirming that discrepancies in experimental outcomes largely stem from variations in psychological methods and participant characteristics.
By considering the underlying reasons for these choices, we propose guidelines for designing perceptual experiments in which spatial frequency and age are manipulated factors.
5Ethnobotanical uses of Salvia speciesSystematische Übersicht2025
Ethnopharmacological evidence revealed 187 Salvia species with documented uses across Asia (Middle East, China), America (Mesoamerica and South America), Africa (Saharan and southern regions), and Europe (Mediterranean and Balkan areas).
Nicolescu A et al. · Journal of ethnopharmacology (2025)
Ethnopharmacological evidence revealed 187 Salvia species with documented uses across Asia (Middle East, China), America (Mesoamerica and South America), Africa (Saharan and southern regions), and Europe (Mediterranean and Balkan areas).
The most frequently cited ailments in which Salvia species are used were gastrointestinal (127), respiratory (86), dermatological (82), and genitourinary (80).
Culinarily, the genus provides aromatic and nutritional properties, increasing the value of diverse dishes and beverages.
The available evidence from clinical trials suggests that Salvia species may improve cognitive performance in healthy subjects and patients with dementia, possibly through acetylcholinesterase inhibitory properties.
Miroddi M et al. · CNS Neuroscience & Therapeutics (2014)
Multiple clinical trials demonstrated improvements in memory and attention in healthy young adults following acute and chronic Salvia officinalis or Salvia lavandulaefolia administration.
Sage extracts exhibit dose-dependent acetylcholinesterase inhibitory activity, mirroring the mechanism of approved Alzheimer's medications.
A randomized controlled trial in patients with mild-to-moderate Alzheimer's disease showed significantly better cognitive outcomes with Salvia officinalis extract compared to placebo over 4 months.
7Lipid profiles and oxidative stress markersRCTCited 2×n=60 · small study2025
Salvia officinalis supplementation significantly improved lipid profiles and reduced oxidative stress markers in women with polycystic ovary syndrome compared to placebo.
Maleki-Hajiagha A et al. · BMC Complementary Medicine and Therapies (2025)
Women with PCOS receiving Salvia officinalis extract showed significant reductions in total cholesterol, LDL cholesterol, and triglycerides compared to the placebo group.
Oxidative stress markers including malondialdehyde (MDA) and total oxidant status (TOS) were significantly reduced in the sage supplementation group.
Total antioxidant capacity (TAC) was significantly increased in the Salvia officinalis group relative to placebo.
12Hot flash frequencyMeta-AnalyseCited 7×n=310 · medium study2023
Sage significantly reduced hot flash frequency in postmenopausal women compared to placebo
Moradi M et al. · Int J Community Based Nurs Midwifery (2023)
Meta-analysis of 4 studies with 310 participants
All 4 studies showed sage reduced hot flash frequency and severity
Significant reduction in hot flash frequency vs placebo
13Menopausal symptomsRCTCited 9×n=80 · small study2021
Salvia off. within 4 weeks significantly reduced the somato-vegetative (e.g. hot flushes) and psychological MRS subscale (e.g. physical and mental exhaustion) subscale (p < 0.05) without a significant effect on the genito-urinary subscale.
Wilfried D, Nina CDG, Silvia B · Heliyon (2021)
Double-blind RCT in 80 menopausal women aged 48-65
Significant reduction in hot flushes, exhaustion, and fatigue
The results of meta-analysis showed that S. officinalis reduced fasting blood sugar (FBS) (mg/dL) (MD: -31.15; 95% CI: -37.56 to -24.73; p<0.00001). It also reduced HbA1c (%) (MD: -0.94; 95% CI: -1.25 to -0.63; p<0.00001).
Abdollahi A et al. · J Complement Integr Med (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Meta-analysis of 3 RCTs on sage in diabetes
Significant reduction in FBS (MD: -31.15 mg/dL, P<0.00001)
Significant reduction in HbA1c (MD: -0.94%, P<0.00001)
16Insulin resistance markersRCTCited 21×n=60 · small study2020
S. officinalis extract at a dose of 330 mg/day could decrease BMI and systolic blood pressure, and it could enhance insulin resistance markers in euglycemic PCOS patients.
Amini L et al. · Complement Ther Med (2020)
Triple-blind RCT in 60 euglycemic PCOS patients
330 mg S. officinalis daily for 8 weeks
Significant improvements in BMI, systolic BP, HOMA-IR, and QUICKI