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Sal5.0

Salicylsäure (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

6 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Salicylsäure (topisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 2003–2024 mit einer typischen Studiengröße von 50 Teilnehmenden.

Basierend auf 6 Studien · 4 RCTs · 197 Teilnehmende insgesamt

Konfidenz

Mittlere Konfidenz

Nach Outcome

Skin healthWeniger Komedonen und entzündliche Akneläsionen (rezeptfreies Akne-Arzneimittel; vergleichbar mit anderen Akne-Wirkstoffen) · 4-12 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Skin tone & pigmentationModerate Verbesserung von Post-Akne-Flecken und Hautbild durch salicylsäurehaltige Peelings (ergänzend/zur Erhaltung; kosmetisch) · 8-16 weeks
Zu wenige bewertete Studien2 Studien
Recovery
Zu wenige bewertete Studien1 Studie

Stetige Forschung

1 Studie in den letzten 5 Jahren

200320132024

1Systematische Übersicht2018

Based on current limited evidence, a robust conclusion cannot be drawn regarding any definitive superiority or equality among the currently used chemical peels.

Chen X, Wang S, Yang M, Li L. · BMJ Open (2018)

Systematic review of 12 RCTs (387 participants) of chemical peels for acne; meta-analysis not possible due to heterogeneity
Salicylic acid peels were not significantly different from trichloroacetic, pyruvic, glycolic, or lipohydroxy acid
Included RCTs were very-low-to-moderate quality, so no definitive efficacy hierarchy could be established — the key counter-evidence

Quelle ansehen

2RCTn=50 · small study2020

About 45% MA peel was found to be equally effective as 30% SA peel in mild-to-moderate facial AV. However, safety and tolerability of MA peel were better than SA peel.

Dayal S, Kalra KD, Sahu P. · J Cosmet Dermatol (2020)

RCT (n=50): 45% mandelic acid vs 30% salicylic acid peels every 2 weeks for six sessions over 12 weeks
Almost equal overall acne improvement; salicylic better on non-inflammatory lesions, mandelic on inflammatory
Fewer adverse effects with the mandelic acid peel — its tolerability advantage

Quelle ansehen

3RCTn=90 · small study2016

GA (35%) and SM acid peels are both equally efficacious and a safe treatment modality for melasma in Indian skin, and are more effective than phytic acid peels. Salicylic-mandelic peels are better tolerated and more suitable for Indian skin.

Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. · Dermatol Surg (2016)

RCT (n=90): glycolic 35% vs salicylic-mandelic vs phytic acid peels for melasma over 12 weeks
MASI reduction ~61% (salicylic-mandelic) vs ~62% (glycolic), no significant difference; both beat phytic acid
Salicylic-mandelic peels better tolerated and judged more suitable for Indian (darker) skin

Quelle ansehen

4RCTn=20 · very small study2008

Both chemical peels were significantly effective by the second treatment (p<.05) and there were no significant differences in effectiveness between the two peels. At 2 months posttreatment, the salicylic acid peel had sustained effectiveness.

Kessler E, Flanagan K, Chia C, Rogers C, Glaser DA. · Dermatol Surg (2008)

Split-face, double-blind RCT (n=20) comparing 30% salicylic acid vs 30% glycolic acid peels, six treatments at 2-week intervals
Both peels significantly reduced papules and pustules with no significant difference in efficacy
The salicylic acid side showed sustained effectiveness at 2 months and fewer adverse events than glycolic acid

Quelle ansehen

5RCTn=37 · small study2003

These results suggest that PCMX + SA cream is as effective as BP gel in the treatment of papulopustular and comedonal acne and that it is better tolerated.

Boutli F, Zioga M, Koussidou T, Ioannides D, Mourellou O. · Drugs Exp Clin Res (2003)

12-week double-blind RCT (n=37) comparing a 2% salicylic acid (plus chloroxylenol) cream vs benzoyl peroxide 5% gel twice daily
Both groups showed marked, statistically comparable improvement (~60% inflammatory, ~55% noninflammatory lesions); no significant between-group difference
Erythema and photosensitivity were significantly fewer in the salicylic acid group

6Übersicht2024

The role of various peeling agents like glycolic acid, salicylic acid, trichloroacetic acid, Jessner's solution, retinoic acid, and lactic acid in the management of melasma has been established as that of an additional or maintenance therapy.

Sarkar R, Katoch S. · Dermatol Clin (2024)

Narrative review of superficial chemical peels (including salicylic acid) for melasma
Positions salicylic acid and other peels as add-on/maintenance therapy rather than standalone first-line treatment
Notes superficial peels are popular for fast recovery and good patient acceptance in a chronic, recurrent disorder

Quelle ansehen

In der Forschungsbibliothek ansehen

Salicylsäure (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

Chemical peels for acne vulgaris: a systematic review of randomised controlled trials.

Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris.

Comparative Evaluation of Efficacy and Tolerability of Glycolic Acid, Salicylic Mandelic Acid, and Phytic Acid Combination Peels in Melasma.

Comparison of alpha- and beta-hydroxy acid chemical peels in the treatment of mild to moderately severe facial acne vulgaris.

Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study.

Chemical Peels in Treatment of Melasma.