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Swp4.0
Saw Palmetto – Forschung
Hilft wahrscheinlich
48 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Saw Palmetto half in etwa der Hälfte (6/9) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 320 Teilnehmenden.
Basierend auf 48 Studien · 7 Meta-Analysen · 26 RCTs · 48,084 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
6geholfen3unklar· 39 weitere ohne bewertete Effektdaten
Nach Outcome
BPH & lower urinary tract symptoms
Hilft wahrscheinlich42 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung13 Studien
Men's vitalityHemmt die 5-alpha-Reduktase, aber die klinische hormonelle Wirkung ist unbewiesen · 4-12 Wochen · Rigorose Studien fanden es bei BPH-Symptomen nicht besser als Placebo · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung12 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung5 Studien
Skin health
Überwiegend Mechanismus / Beobachtung4 Studien
Women's health
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 39 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
40%
über Studien hinweg
Untersuchte Personen
48k
typische Studie: 320 Personen
Stärkste Designs
33
7 gepoolt, 26 randomisiert
Zeigte Nutzen
67%
6/9 Studien
Wie lange Studien liefen
1–3 Monate
5
3+ Monate
4
Untersuchte Populationen
Men with BPH10
Men with lower urinary tract symptoms2
General population2
Men with benign prostatic enlargement1
Aktives Forschungsgebiet
18 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200520152026
1BPH symptomsSystematische Übersichtn=5,000 · very large study2012
Saw palmetto was not superior to placebo for BPH symptoms.
Tacklind J et al. · Cochrane Database of Systematic Reviews (2012)
Natural products such as rosemary, green tea, ginseng, Aloe vera, olive, and saw palmetto have shown promising efficacy in promoting hair growth, improving hair density, reducing hair shedding, and enhancing patient satisfaction through mechanisms involving anti-inflammatory, hormonal, and enhanced scalp circulation.
Allam AT et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
However, study design limitations and outcome variability necessitate further rigorous, standardized research.
This review aims to offer an integrative, evidence-informed perspective on the therapeutic potential of herbal medicine for hair loss in clinical evidence.
6Concurrent prescription drugs and herbal medicine use prevalenceSystematische ÜbersichtCited 69×2017
The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported.
Agbabiaka TB et al. · Drugs & aging (2017)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Prevalence of concurrent use by older adults varied widely between 5.3 and 88.3%.
The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported.
Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals in appropriately identifying and managing patients at risk.
8quality of lifeSystematische Übersichtn=4,656 · very large study2023
Serenoa repens alone provides little to no benefits for men with lower urinary tract symptoms due to benign prostatic enlargement.
Franco JV et al. · The Cochrane database of systematic reviews (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Serenoa repens results in little to no difference in the quality of life at short-term follow-up (3 to 6 months; IPSS quality of life domain range 0 to 6, higher scores indicate worse quality of life; MD -0.20, 95% CI -0.40 to -0.00; I2 = 39%; 5 studies, 1001 participants; high-certainty evidence).
Serenoa repens probably results in little to no difference in adverse events (1 to 17 months; risk ratio (RR) 1.01, 95% CI 0.77 to 1.31; I2 = 18%; 12 studies, 2399 participants; moderate-certainty evidence).
Serenoa repens results in little to no difference in urologic symptoms at long-term follow-up (12 to 17 months, IPSS score, MD 0.07, 95% CI -0.75 to 0.88; I2 = 34%; 3 studies, 898 participants; high-certainty evidence).
While the significance of many interactions is uncertain, several interactions, particularly those with St John's wort, may have serious clinical consequences.
Izzo AA et al. · Drugs (2009)
Echinacea might affect the clearance of caffeine (a CYP1A2 probe) and midazolam (a CYP3A4 probe).
No interactions have been reported for saw palmetto (Serenoa repens).
Numerous interactions between herbal medicines and conventional drugs have been documented.
12Adverse events assessmentSystematische ÜbersichtCited 53×n=26 · very small study2009
However, higher quality reporting of adverse events is essential if safety assessments are to be improved in future.
Agbabiaka TB et al. · Drug safety (2009)
Currently available data suggest that S. repens is well tolerated by most users and is not associated with serious adverse events.
The majority of adverse events are mild, infrequent and reversible, and include abdominal pain, diarrhoea, nausea and fatigue, headache, decreased libido and rhinitis.
We found no evidence for drug interactions with S. repens.
13Systematic review of saw palmetto evidenceSystematische ÜbersichtCited 9×2006
Here presented is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Ulbricht C et al. · Journal of the Society for Integrative Oncology (2006)
Here presented is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
14Lower urinary tract symptoms (LUTS)RCTCited 3×n=76 · small study2022
In conclusion, the present study is the first to demonstrate the potential of SPE to mitigate LUTS in adult women.
Yamada S et al. · Nutrients (2022)
The daytime frequency of urination in overactive bladder symptom score (OABSS) Q1 was also significantly improved by the SPE treatment.
A subgroup analysis revealed that SPE alleviated the symptoms of daytime frequency (CLSS Q1) and nocturia (CLSS Q2) in a subset of subjects with a CLSS Q5 score of 1 or higher.
In conclusion, the present study is the first to demonstrate the potential of SPE to mitigate LUTS in adult women.
16Urinary frequency-related quality of lifeRCTCited 2×n=34 · small study2025
The consumption of SPE improved urinary frequency-related quality of life such as bother of urinary symptoms in healthy Japanese adults (UMIN000045334).
Kimura M et al. · Nutrition and health (2025)
After SPE intervention for 12 weeks, the score of symptom bother by frequent urination during the daytime hours was significantly improved and the daytime frequency of urination assessed using the urinary log was significantly decreased.
The other outcomes were subjective urinary symptoms and urinary frequencies.
The final efficacy analysis dataset was per protocol set, and 33 participants in each group were analyzed.
17Treatment assignment blinding successRCTCited 5×n=151 · medium study2014
Blinding of treatment assignment was successful in this study.
Lee JY et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2014)
Could be chance
For participants assigned to saw palmetto, 22.5%, 24.7%, and 29.8% correctly thought they were taking saw palmetto, and 37.3%, 40.0%, and 44.4% incorrectly thought they were on placebo at 24, 48, and 72 weeks, respectively.
For placebo participants, 21.8%, 27.4%, and 25.2% incorrectly thought they were on saw palmetto, and 41.6%, 39.9%, and 42.6% correctly thought they were on placebo at 24, 48, and 72 weeks, respectively.
The treatment arms did not vary with respect to the distributions of participants who guessed they were on saw palmetto (p=0.823) or placebo (p=0.893).
18Nocturnal voiding frequencyRCTCited 9×n=922 · large study2014
PRO 160/120 significantly improved nocturnal voiding frequency compared to placebo and similar to tamsulosin or finasteride.
Oelke M et al. · World journal of urology (2014)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
In the pooled analysis of placebo-controlled trials, nocturnal voids improved by 0.8 (29 %) with PRO 160/120 compared to 0.6 (18 %) with placebo (p = 0.015, Wilcoxon test, one-tailed).
The 69 % responder rate to PRO 160/120 was significantly superior to the placebo response (52 %; p = 0.003, χ (2)-test, two-tailed).
PRO 160/120 significantly improved nocturnal voiding frequency compared to placebo and similar to tamsulosin or finasteride.
The daily use of a proprietary saw palmetto (Serenoa repens) extract safely and effectively promotes hair growth in men and women with self-perceived thinning hair.
Ablon G · Journal of cosmetic dermatology (2026)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Mean (SD) change in baseline total terminal hair count was +18.6 (29.6) with active vs. -10.1 (30.5) with placebo (p < 0.001; 283% greater improvement).
Total vellus hair count increased +6.6 (15.6) vs. -2.1 (15.7) (p < 0.05; 414% greater improvement).
Total hair density rose +25.1 (27.7) vs. -12.2 (38.8) (p < 0.001; 306% greater improvement).
20Lower urinary tract symptoms in BPHRCTn=46 · small study2024
Our findings support the efficacy of USP-verified Saw Palmetto extract in alleviating LUTS in men with BPH.
Winograd J et al. · The Canadian journal of urology (2024)
Results from 46 patients using 320 mg daily of USP-verified Saw Palmetto extract revealed significant improvements in IPSS and QoL scores at 12 weeks compared to baseline, particularly in patients with moderate symptoms.
Our findings support the efficacy of USP-verified Saw Palmetto extract in alleviating LUTS in men with BPH.
Further studies are warranted in larger, diverse cohorts over longer follow up periods.