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Swp4.0
Saw Palmetto – Forschung
Hilft wahrscheinlich
73 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Saw Palmetto half in etwa der Hälfte (6/9) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2002–2026 mit einer typischen Studiengröße von 225 Teilnehmenden.
Basierend auf 73 Studien · 9 Meta-Analysen · 45 RCTs · 33,676 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
6geholfen3unklar· 64 weitere ohne bewertete Effektdaten
Nach Outcome
BPH & lower urinary tract symptoms
Hilft vermutlich64 Studien
Men's vitalityHemmt die 5-alpha-Reduktase, aber die klinische hormonelle Wirkung ist unbewiesen · 4-12 Wochen · Rigorose Studien fanden es bei BPH-Symptomen nicht besser als Placebo · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung15 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung15 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung9 Studien
Skin health
Überwiegend Mechanismus / Beobachtung7 Studien
Women's health
Überwiegend Mechanismus / Beobachtung3 Studien
Inflammation
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 34 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
40%
über Studien hinweg
Untersuchte Personen
34k
typische Studie: 225 Personen
Stärkste Designs
54
9 gepoolt, 45 randomisiert
Zeigte Nutzen
67%
6/9 Studien
Wie lange Studien liefen
1–3 Monate
5
3+ Monate
3
Untersuchte Populationen
Men with BPH7
Men with lower urinary tract symptoms2
Patients with hair loss1
Men with benign prostate hyperplasia1
Aktives Forschungsgebiet
23 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200220142026
1Urinary flow rate and nocturiaMeta-Analysen=5,222 · very large study2018
Einfach gesagt: Saw palmetto extract significantly improved urinary flow rate and nocturia compared to placebo in men with BPH.
Vela-Navarrete R et al. · BJU International (2018)
Significant improvement in maximum urinary flow rate vs placebo
Reduced nocturia frequency compared to placebo
Hexanic lipidosterolic extract (Permixon) showed most consistent results
Zong HT, Wang XY, Wang T, Zhou X, Zhang Y · Zhonghua Nan Ke Xue (2019)
6Hair lossSystematische Übersicht2025
Einfach gesagt: Natural products such as rosemary, green tea, ginseng, Aloe vera, olive, and saw palmetto have shown promising efficacy in promoting hair growth, improving hair density, reducing hair shedding, and enhancing patient satisfaction through mechanisms involving anti-inflammatory, hormonal, and enhanced scalp circulation.
Allam AT et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
However, study design limitations and outcome variability necessitate further rigorous, standardized research.
This review aims to offer an integrative, evidence-informed perspective on the therapeutic potential of herbal medicine for hair loss in clinical evidence.
Einfach gesagt: We performed a GRADE evaluation of the quality of evidence for interventions.
McNicholas T et al. · BMJ clinical evidence (2011)
Systematic review examining Saw Palmetto efficacy
Further research warranted to confirm findings
9Prevalence of concurrent prescription drugs and herbal medicinal products useSystematische Übersicht2017
Einfach gesagt: The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported.
Agbabiaka TB et al. · Drugs & aging (2017)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Prevalence of concurrent use by older adults varied widely between 5.3 and 88.3%.
The prevalence of concurrent prescription drugs and HMP use among older adults is substantial and potential interactions have been reported.
Knowledge of the extent and manner in which older adults combine prescription drugs will aid healthcare professionals in appropriately identifying and managing patients at risk.
13quality of lifeÜbersichtn=4,656 · very large study2023
Einfach gesagt: Serenoa repens alone provides little to no benefits for men with lower urinary tract symptoms due to benign prostatic enlargement.
Franco JV et al. · The Cochrane database of systematic reviews (2023)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Serenoa repens results in little to no difference in the quality of life at short-term follow-up (3 to 6 months; IPSS quality of life domain range 0 to 6, higher scores indicate worse quality of life; MD -0.20, 95% CI -0.40 to -0.00; I2 = 39%; 5 studies, 1001 participants; high-certainty evidence).
Serenoa repens probably results in little to no difference in adverse events (1 to 17 months; risk ratio (RR) 1.01, 95% CI 0.77 to 1.31; I2 = 18%; 12 studies, 2399 participants; moderate-certainty evidence).
Serenoa repens results in little to no difference in urologic symptoms at long-term follow-up (12 to 17 months, IPSS score, MD 0.07, 95% CI -0.75 to 0.88; I2 = 34%; 3 studies, 898 participants; high-certainty evidence).
15Herbal medicine drug interactionsSystematische Übersicht2009
Einfach gesagt: While the significance of many interactions is uncertain, several interactions, particularly those with St John's wort, may have serious clinical consequences.
Izzo AA et al. · Drugs (2009)
Echinacea might affect the clearance of caffeine (a CYP1A2 probe) and midazolam (a CYP3A4 probe).
No interactions have been reported for saw palmetto (Serenoa repens).
Numerous interactions between herbal medicines and conventional drugs have been documented.
16Systematic review of saw palmetto evidenceSystematische Übersicht2006
Einfach gesagt: Here presented is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Ulbricht C et al. · Journal of the Society for Integrative Oncology (2006)
Here presented is an evidence-based systematic review including written and statistical analysis of scientific literature, expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
17Urinary frequency-related quality of lifeRCTn=34 · small study2025
Einfach gesagt: The consumption of SPE improved urinary frequency-related quality of life such as bother of urinary symptoms in healthy Japanese adults (UMIN000045334).
Kimura M et al. · Nutrition and health (2025)
After SPE intervention for 12 weeks, the score of symptom bother by frequent urination during the daytime hours was significantly improved and the daytime frequency of urination assessed using the urinary log was significantly decreased.
The other outcomes were subjective urinary symptoms and urinary frequencies.
The final efficacy analysis dataset was per protocol set, and 33 participants in each group were analyzed.
18Lower urinary tract symptoms (LUTS)RCTn=76 · small study2022
Einfach gesagt: In conclusion, the present study is the first to demonstrate the potential of SPE to mitigate LUTS in adult women.
Yamada S et al. · Nutrients (2022)
The daytime frequency of urination in overactive bladder symptom score (OABSS) Q1 was also significantly improved by the SPE treatment.
A subgroup analysis revealed that SPE alleviated the symptoms of daytime frequency (CLSS Q1) and nocturia (CLSS Q2) in a subset of subjects with a CLSS Q5 score of 1 or higher.
In conclusion, the present study is the first to demonstrate the potential of SPE to mitigate LUTS in adult women.
20Treatment assignment blinding successRCTn=151 · medium study2014
Einfach gesagt: Blinding of treatment assignment was successful in this study.
Lee JY et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2014)
Could be chance
For participants assigned to saw palmetto, 22.5%, 24.7%, and 29.8% correctly thought they were taking saw palmetto, and 37.3%, 40.0%, and 44.4% incorrectly thought they were on placebo at 24, 48, and 72 weeks, respectively.
For placebo participants, 21.8%, 27.4%, and 25.2% incorrectly thought they were on saw palmetto, and 41.6%, 39.9%, and 42.6% correctly thought they were on placebo at 24, 48, and 72 weeks, respectively.
The treatment arms did not vary with respect to the distributions of participants who guessed they were on saw palmetto (p=0.823) or placebo (p=0.893).