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Se6.5
Selenium – Forschung
Hilft wahrscheinlich
716 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Selenium scheint in 21 von 26 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1981–2026 mit einer typischen Studiengröße von 282 Teilnehmenden.
Basierend auf 716 Studien · 177 Meta-Analysen · 399 RCTs · 189,158 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
21geholfen4unklar1nicht geholfen· 690 weitere ohne bewertete Effektdaten
Nach Outcome
Therapeutic & clinical
Hilft wahrscheinlich153 Studien
Thyroid function
Hilft wahrscheinlich62 Studien
Women's healthAntioxidative und schilddrüsenunterstützende Wirkung · Fortlaufend · Selenoproteine (GPx) reduzieren oxidativen Stress und Entzündungen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung62 Studien
InflammationLiefert essenzielle Nährstoffe für eine gesunde Schwangerschaft · Fortlaufend
Hilft vermutlich58 Studien
Safety profile
Hilft wahrscheinlich50 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung41 Studien
Men's vitalityKann die reproduktive Gesundheit und Fertilitätsmarker unterstützen · 4-12 Wochen · Antioxidative Unterstützung der Prostata · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung34 Studien
Immune supportDer Selenstatus korreliert mit der Stimmung; eine Korrektur verbessert Angstzustände und Depressionen · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung29 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung28 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung19 Studien
Neuroprotection & brain agingUnterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen
Überwiegend Mechanismus / Beobachtung18 Studien
Fertility & reproductive
Überwiegend Mechanismus / Beobachtung13 Studien
Cholesterol & lipids
Überwiegend Mechanismus / Beobachtung10 Studien
Depression & moodSelenoprotein-vermittelte antioxidative Abwehr im ZNS · Fortlaufend
Überwiegend Mechanismus / Beobachtung9 Studien
Skin health
Überwiegend Mechanismus / Beobachtung7 Studien
Joint pain & arthritis
Überwiegend Mechanismus / Beobachtung7 Studien
Liver health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 89 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
82%
über Studien hinweg
Untersuchte Personen
189k
typische Studie: 282 Personen
Stärkste Designs
576
177 gepoolt, 399 randomisiert
Zeigte Nutzen
81%
21/26 Studien
Wie lange Studien liefen
1–3 Monate
1
3+ Monate
2
Untersuchte Populationen
General population8
Hashimoto's thyroiditis patients4
COVID-19 patients4
Alzheimer's disease patients2
Aktives Forschungsgebiet
278 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
198120032026
1Meta-Analysen=4,162 · very large study2023
Einfach gesagt: However, additional investigation is necessary to ascertain whether there is a potential association between these variables.
Li J et al. · Nutrients (2023)
All three methods of MR analysis revealed that Se levels had no effect on OP risk.
In addition, the sensitivity analysis revealed no heterogeneity or pleiotropy, and the significance of the overall effect remained unaffected by single-nucleotide polymorphisms (SNPs), as determined by the leave-one-out analysis, indicating that our findings are relatively reliable.
The results of our study indicate that there is no causal association between Se levels and the risk of OP.
3QUICKI improvementMeta-Analysen=2,362 · very large study2023
Einfach gesagt: Carnitine was relatively effective in reducing body mass, while chromium, Omega-3, and selenium were beneficial for improving glucose metabolism.
Hu X et al. · PeerJ (2023)
The network meta-analysis showed that carnitine, inositol, and probiotics reduced body weight and body mass index (BMI) compared to placebo, and carnitine outperformed the other supplements (SUCRAs: 96.04%, 97.73%, respectively).
Omega-3 lowered fasting blood glucose (FBG) (SUCRAs: 93.53%), and chromium reduced fasting insulin (FINS) (SUCRAs: 72.90%); both were superior to placebo in improving insulin resistance index (HOMA-IR), and chromium was more effective than Omega-3 (SUCRAs: 79.99%).
Selenium was potent in raising the quantitative insulin sensitivity index (QUICKI) (SUCRAs: 87.92%).
4Selenium levels in vitiligo patientsMeta-Analysen=8,542 · very large study2024
Einfach gesagt: Patients with vitiligo should reduce smoking and alcohol consumption and take appropriate vitamin E, B12, copper, and zinc supplements.
Liang X et al. · Frontiers in immunology (2024)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Vitamin C [mean difference (MD), -0.342; 95% confidence interval (CI), -1.090-0.407; p >0.05), folic acid (MD, -1.463; 95% CI, -7.133-4.208; p >0.05), and selenium (MD, 0.350; 95% CI, -0.687-1.387; p >0.05) levels did not differ between the groups.
The serum iron level of the vitiligo group was significantly higher than that of the control group (MD, 1.181; 95% CI, 0.390-1.972; p <0.005).
Patients with vitiligo should reduce smoking and alcohol consumption and take appropriate vitamin E, B12, copper, and zinc supplements.
5TSH levels in patients without THRTMeta-Analysen=869 · large study2024
Einfach gesagt: Indications for lowering TPOAb were found independent of THRT.
Huwiler VV et al. · Thyroid : official journal of the American Thyroid Association (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
We synthesized the results as standardized mean differences (SMD) or odds ratio (OR), assessed risk of bias using the Cochrane RoB 2 tool, and rated the evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
Our meta-analysis found that selenium supplementation decreased TSH in patients without THRT (SMD -0.21 [confidence interval, CI -0.43 to -0.02]; 7 cohorts, 869 participants; I2 = 0%).
In addition, TPOAb (SMD -0.96 [CI -1.36 to -0.56]; 29 cohorts; 2358 participants; I2 = 90%) and malondialdehyde (MDA; SMD -1.16 [CI -2.29 to -0.02]; 3 cohorts; 248 participants; I2 = 85%) decreased in patients with and without THRT.
6Prostate cancer riskMeta-Analysen=13,254 · very large study2012
Einfach gesagt: The relation between selenium status and decreased prostate cancer risk was examined over a relatively narrow range of selenium status; further studies in low-selenium populations are required.
Hurst R et al. · The American journal of clinical nutrition (2012)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Three high-quality studies included in the meta-analysis of toenail selenium and cancer risk indicated a reduction in prostate cancer risk (estimated RR: 0.29; 95% CI: 0.14, 0.61) with a toenail selenium concentration between 0.85 and 0.94 μg/g.
The relation between selenium status and decreased prostate cancer risk was examined over a relatively narrow range of selenium status; further studies in low-selenium populations are required.
8Selenium levels in skin diseasesMeta-Analysen=1,315 · large study2020
Einfach gesagt: Selenium levels were associated with several skin diseases and the disease severity, and high selenium levels tended to be a protective factor in certain skin diseases.
Lv J et al. · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (2020)
Groß Nutzen
← SchlechterKein EffektBesser →
Compared with controls, no significant difference in selenium was found in patients with vitiligo (SMD = 0.53, 95% CI: -0.40 to 1.45), alopecia areata (SMD = 0.47, 95% CI: -2.72 and 3.65), or eczema (SMD = 0.12, 95% CI: -0.24 to 0.48).
A lower selenium level was found in patients with psoriasis (SMD = -0.62, 95% CI: -1.15 to -0.10), acne vulgaris (SMD = -1.02, 95% CI: -1.45 to -0.60), chloric acne (SMD = -2.35, 95% CI: -3.15 to -1.55), and atopic dermatitis (SMD = -2.62, 95% CI: -3.00 to -2.24).
As for disease severity, severe patients had a higher selenium level than mild patients in psoriasis (SMD = 0.72, 95% CI: 0.07-1.38), but no difference was found in vitiligo (SMD = -0.26, 95% CI: -2.38 to 1.85) and alopecia areata (SMD = 0.46, 95% CI: -0.34 to 1.26).