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Srp4.0

Serrapeptase – Forschung

Überwiegend Mechanismus / Beobachtung

24 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Serrapeptase sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1983–2026 mit einer typischen Studiengröße von 90 Teilnehmenden.

Basierend auf 24 Studien · 2 Meta-Analysen · 14 RCTs · 576 Teilnehmende insgesamt

Konfidenz

Hohe Konfidenz

Was die Studien gefunden haben

0geholfen1unklar· 23 weitere ohne bewertete Effektdaten

Nach Outcome

Surgical recovery & post-op edemaSchnellere Heilung nach Verletzungen/Operationen · 1-2 Wochen
Überwiegend Mechanismus / Beobachtung17 Studien
InflammationReduzierte Schwellung und Entzündung · 1-2 Wochen
Überwiegend Mechanismus / Beobachtung5 Studien
Pain & analgesia
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Women's health
Zu wenige bewertete Studien2 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien

In Zahlen

Aus 10 Studien mit messbaren Effekten gezogen

Untersuchte Personen

576

typische Studie: 90 Personen

Stärkste Designs

2 gepoolt, 14 randomisiert

Zeigte Nutzen

0/1 Studien

Wie lange Studien liefen

Unter einer Woche

1–4 Wochen

1–3 Monate

Untersuchte Populationen

Cardiovascular patients1

Patients with blood thrombi1

Patients undergoing impacted molar surgery1

patients with inflammatory conditions1

Stetige Forschung

7 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2021

198320042026

1Serratiopeptidase therapeutic applications and improvementsSystematische ÜbersichtCited 1×2024

Hosseini SB et al. · Archives of microbiology (2024)

To overcome such limitations, improved versions of the enzyme were introduced using protein engineering in our previous studies.
Novel functional serratiopeptidases with shorter length and higher stability have seemingly created a hope for using this enzyme as a more effective therapeutic enzyme.

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2Serratiopeptidase therapeutic and clinical applicationsSystematische ÜbersichtCited 24×2022

In addition, the review highlights the therapeutic and clinical aspects of the serratiopeptidase enzyme to combat COVID-19-induced respiratory syndrome.

Nair SR et al. · Biomolecules (2022)

Existing serratiopeptidase treatments in combination with antibiotics are popular in the treatment of postoperative swelling.
Although an exclusive number of serratiopeptidase-producing strains have been derived, there is an urge for new recombinant strains to enhance the production of the enzyme.
This review explores the properties of serratiopeptidase, different therapeutic aspects, industrial production, and various analytical techniques used in enzyme recovery.

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3Thrombolytic therapy effectivenessSystematische ÜbersichtCited 25×2019

Reported enzymes from various sources with potential to be used as cardiovascular therapeutic is also discussed here.

Kumar SS et al. · Advances in experimental medicine and biology (2019)

Inability of plasma fibrinolytic system demands better thrombolytic drugs.
Major thrombolytic enzymes belonging to plasminogen activators and plasmin like enzymes.
Currently used fibrinolytic enzymes and their limitations are revisited in the present chapter.

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4Fibrinolytic enzyme thrombolytic potentialSystematische ÜbersichtCited 36×2014

This review is the first to cover all the natural and recombinant thrombolytic agents used in enzyme therapy.

Kotb E · Biotechnology progress (2014)

According to data provided by the World Health Organization (WHO) in 2000, heart diseases are responsible for 29% of the total mortality rate in the world.
Furthermore, recombinant DNA technology has succeeded in improving and decreasing the undesirable effects of the first generation of enzymes.
This review is the first to cover all the natural and recombinant thrombolytic agents used in enzyme therapy.

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5Anti-inflammatory, anti-edemic and analgesic effectsSystematische ÜbersichtCited 56×n=24 · very small study2013

Serratiopeptidase is being used in many clinical specialities for its anti-inflammatory, anti-edemic and analgesic effects.

Bhagat S et al. · International journal of surgery (London, England) (2013)

Serratiopeptidase is being used in many clinical specialities for its anti-inflammatory, anti-edemic and analgesic effects.
It is even being promoted as a health supplement to prevent cardiovascular morbidity.
The existing scientific evidence for Serratiopeptidase is insufficient to support its use as an analgesic and health supplement.

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6Trismus and facial swelling after impacted molar surgeryMeta-Analysen=5 · very small study2018

Serratiopeptidase could be used safely and effectively to improve trismus and facial swelling after surgical removal of impacted molar.

Sivaramakrishnan G et al. · Journal of Maxillofacial and Oral Surgery (2018)

Five studies were included for final review.
Serratiopeptidase improved trismus better than corticosteroids with the MD, 95% as 4.42 [3.84, 5].
As regards to swelling, no significant difference was observed for serratiopeptidase when compared to corticosteroids.

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7Systematische Übersicht2020

Zakarija-Grkovic I, Stewart F · Cochrane Database Syst Rev (2020)

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8Systematische Übersicht2013

Bhagat S, Agarwal M, Roy V · Int J Surg (2013)

Quelle ansehen

9inflammatory markersMeta-Analysen=312 · medium study2021

This meta-analysis provides evidence for serrapeptase's anti-inflammatory effects across multiple conditions.

Tiwari M et al. · International Journal of Surgery (2021)

Significant reduction in inflammatory markers (CRP, IL-6) compared to placebo
Improved pain scores in post-operative and chronic pain conditions
Enhanced mucus clearance in respiratory conditions

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10RCT2021

Tamimi Z, Al Habashneh R, Hamad I, Al-Ghazawi M, Roqa'a AA, Kharashgeh H · BMC Oral Health (2021)

Quelle ansehen

11RCT2017

Chandanwale A, Langade D, Sonawane D, Gavai P · Adv Ther (2017)

Quelle ansehen

12RCT2012

Murugesan K, Sreekumar K, Sabapathy B · Indian J Dent Res (2012)

Quelle ansehen

13RCT2009

Chopra D, Rehan HS, Mehra P, Kakkar AK · Int J Oral Maxillofac Surg (2009)

Quelle ansehen

14RCT2008

Al-Khateeb TH, Nusair Y · Int J Oral Maxillofac Surg (2008)

Quelle ansehen

15RCT2003

Nakamura S, Hashimoto Y, Mikami M, Yamanaka E, Soma T, Hino M · Respirology (2003)

Quelle ansehen

16RCT1996

Bracale G, Selvetella L · Minerva Cardioangiol (1996)

17RCT1990

Mazzone A, Catalani M, Costanzo M, Drusian A, Mandoli A, Russo S · J Int Med Res (1990)

Quelle ansehen

18RCT1989

Esch PM, Gerngross H, Fabian A · Fortschr Med (1989)

19RCT1989

Kee WH, Tan SL, Lee V, Salmon YM · Singapore Med J (1989)

20RCT1984

Tachibana M, Mizukoshi O, Harada Y, Kawamoto K, Nakai Y · Pharmatherapeutica (1984)

In der Forschungsbibliothek ansehen

Serrapeptase – Forschung

Überwiegend Mechanismus / Beobachtung

In Zahlen

An up-to-date review of biomedical applications of serratiopeptidase and its biobetter derivatives as a multi-potential metalloprotease

Serratiopeptidase: An integrated View of Multifaceted Therapeutic Enzyme

Fibrinolytic Enzymes for Thrombolytic Therapy

The biotechnological potential of fibrinolytic enzymes in the dissolution of endogenous blood thrombi

Serratiopeptidase: a systematic review of the existing evidence

Role of Serratiopeptidase After Surgical Removal of Impacted Molar: A Systematic Review and Meta-analysis

Treatments for breast engorgement during lactation.

Serratiopeptidase: a systematic review of the existing evidence.

Serrapeptase supplementation for inflammatory conditions: A systematic review and meta-analysis

Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial.

A Randomized, Clinical Trial to Evaluate Efficacy and Tolerability of Trypsin:Chymotrypsin as Compared to Serratiopeptidase and Trypsin:Bromelain:Rutoside in Wound Management.

Comparison of the roles of serratiopeptidase and dexamethasone in the control of inflammation and trismus following impacted third molar surgery.

A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.

Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.

Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease.

[Clinical study of the efficacy of and tolerance to seaprose S in inflammatory venous disease. Controlled study versus serratio-peptidase].

Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo.

[Reduction of postoperative swelling. Objective measurement of swelling of the upper ankle joint in treatment with serrapeptase-- a prospective study].

The treatment of breast engorgement with Serrapeptase (Danzen): a randomised double-blind controlled trial.

A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling.