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Sl5.0
Silica – Forschung
Überwiegend Mechanismus / Beobachtung
27 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Silica sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 48 Teilnehmenden.
Basierend auf 27 Studien · 2 Meta-Analysen · 5 RCTs · 625 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung11 Studien
Bone healthDer Nutzen für die Knochen beruht auf Beobachtungs- und mechanistischen Daten, nicht auf Studien · 8-12 weeks
Überwiegend Mechanismus / Beobachtung10 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung9 Studien
Skin healthVerbesserte Hautelastizität in einer Orthokieselsäure-RCT · 20 weeks · Eine kleine ch-OSA-RCT verbesserte die mechanischen Eigenschaften der Haut über 20 Wochen · 12-20 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Hair & nails
Zu wenige bewertete Studien2 Studien
Cognitive function
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 5 Studien mit messbaren Effekten gezogen
Untersuchte Personen
625
typische Studie: 48 Personen
Stärkste Designs
7
2 gepoolt, 5 randomisiert
Untersuchte Populationen
Elderly1
Postmenopausal women1
Adults1
Premenopausal women and men1
Aktives Forschungsgebiet
21 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200520152026
1Systematische Übersichtn=10 · very small study2024
Future research should measure multiple trace mineral levels in all water sources to evaluate the impact on cognitive function.
Wasick A et al. · International journal of environmental research and public health (2024)
The prevalence of dementia increases with nearly 10 million new cases each year, with Alzheimer's disease contributing to 60-70% of cases.
Aluminum exposure showed an increased risk of cognitive decline in four studies, with no association reported in the other studies.
Higher silica and pH levels were shown to be protective against a decline in cognitive function.
We believe that a possible future direction is an integrated development strategy of "intelligent design-precise regulation-green optimization", offering theoretical and practical guidance for advancing nano-luminescent materials toward real-world applications in biomedicine, optoelectronics, and environmental monitoring.
Cui K, Zhang L, Ding L, Peng H, Fang Y. · Advances in colloid and interface science (2026)
Furthermore, advanced architectures such as core-shell, Janus, and chiral structures extend the functional boundaries of SiO 2 -based systems, unlocking opportunities in bioimaging, anti-counterfeiting, and smart sensing.
Finally, current challenges, such as scalable synthesis, stability under extreme environments, and potential biosafety risks, are critically discussed.
According to reported studies, among the different chemical forms available, the orthosilicic acid (OSA) presents the higher bioavailability, whereas the others forms have absorption inversely proportional to the degree of polymerization.
Araújo LA et al. · Anais Brasileiros de Dermatologia (2016)
On the skin, it is suggested that silicon is important for optimal collagen synthesis and activation of hydroxylating enzymes, improving skin strength and elasticity.
It was suggested that a higher silicon content in the hair results in a lower rate of hair loss and increased brightness.
Silicon supplements are widely used, though there is wide variation in silicon bioavailability, ranging from values below 1% up to values close to 50%, depending on the chemical form.
Our data demonstrate that compared with placebo, collagen peptide supplementation in combination with resistance training further improved body composition by increasing FFM, muscle strength and the loss in FM.
Zdzieblik D et al. · The British journal of nutrition (2015)
Isokinetic quadriceps strength (IQS) of the right leg was determined and sensory motor control (SMC) was investigated by a standardised one-leg stabilisation test.
Following the training programme, all the subjects showed significantly higher (P<0·01) levels for FFM, BM, IQS and SMC with significantly lower (P<0·01) levels for FM.
Our data demonstrate that compared with placebo, collagen peptide supplementation in combination with resistance training further improved body composition by increasing FFM, muscle strength and the loss in FM.
The translational issues, design, and future prospects of silica-enabled immunonanomedicine are also brought to the forefront to provide a balanced, forward-looking perspective on their potential for reprogramming the immune microenvironment.
Shamim S, Singh AP, Sharma H, Gohri S, Taumar D, Chaudhary V. · Drug delivery and translational research (2026)
Notably, nanocarriers consisting of mesoporous surface-functionalized silica nanoparticles are especially beneficial, due to a high drug-loading capacity, a programmable pore architecture, structural stability, and a versatile surface chemistry.
This review critically examines the design and immunological application of silica nanocarriers in cancer immunotherapy.
Tumor immune evasion mechanisms and silica platforms in antigen-presenting cells targeting, tumor-associated macrophage reprogramming, localized immune checkpoint regulation, and T-cell stimulation are mentioned.
The main findings show that nano-silica offers a pathway to tailored, low-carbon geopolymers with superior microstructure-performance relationships aligned with sustainable construction goals.
Comprehensive characterization methods are critically assessed, including SEM/EDS for gel morphology, MIP for porosity profiles, XRD/FTIR for reaction products, micro-CT for 3D void networks, and nanoindentation for ITZ mechanical gradients.
The article also shows the main applications span high-performance concretes, 3D-printed geopolymer elements (improved buildability and interlayer adhesion), and durable overlays.
The article is a closed presentation of challenges such as long-term stability, alongside future directions.
These insights support the development of predictive structure-property frameworks for advanced biomedical and controlled release applications.
Raiciu AD, Stefaniu A. · Gels (Basel, Switzerland) (2026)
The analysis highlights how nanoparticle size, loading level, and surface functionalization influence relaxation spectra and network topology, as well as how environmental stimuli may affect supramolecular bond stability and overall material performance.
Comparison with alternative inorganic fillers and mesoporous silica architectures further clarifies the specific advantages of silica in achieving balanced mechanical stability and controlled transport behavior.
Overall, current evidence indicates that hybrid CD-silica networks enable partial decoupling of stiffness, relaxation dynamics, and diffusion, although complete independence remains constrained by fundamental polymer physics relationships.
The present review aims to comprehensively discuss the current state of magnetic nanoreactors for bioorthogonal catalysis, addressing key challenges in biological integration and projecting future directions for clinical and diagnostic translation.
Bhujbal S et al. · Nanoscale (2026)
Systems based on Fe-Pd nanowires, silica-confined catalytic shells, magnetothermia-responsive nanoreactors, SPAAC-clickable surfaces, and cascade magnetic sensors show that MNPs may carry out effective and selective catalysis in challenging biological settings.
All things considered, MNP platforms offer a viable approach for secure, focused, and manageable bioorthogonal reactions that are beneficial for medical and diagnostic uses.
In addition, recent developments in bioorthogonal catalysis activated by external stimuli such as light, ultrasound, and other physical fields are briefly discussed.
These comprehensive findings indicate that MSN-based delivery systems offer a powerful strategy to overcome the intrinsic pharmacokinetic limitations of poorly soluble compounds and warrant further investigation into their long-term safety and clinical application.
Aulifa DL et al. · International journal of nanomedicine (2026)
Mesoporous silica nanoparticles (MSNs) have emerged as promising drug delivery systems due to their high surface area, tunable pore size, and high pore volume, which enable enhanced drug loading and stabilization of drugs in an amorphous state.
These properties are critical for improving dissolution behavior.
These comprehensive findings indicate that MSN-based delivery systems offer a powerful strategy to overcome the intrinsic pharmacokinetic limitations of poorly soluble compounds and warrant further investigation into their long-term safety and clinical application.
Finally, it outlines the challenges and prospects associated with the application of hydrogel-modified silica in separation science.
Zhang T, Liang X, Lin H, Liu R, Li N, Li Z, Liu L, Zhang Y. · The Analyst (2026)
This review provides a succinct overview of the performance and recent advancements of hydrogel-modified silica stationary phases in high-performance liquid chromatography (HPLC).
It also provides an in-depth discussion on the use of hydrogel-modified silica stationary phase composites for the separation of analytes in various chromatographic modes.
Efficient separation and analysis of analytes crucial to life sciences and medicine, such as nucleoside bases, steroid hormones, antibiotics, pesticides, and environmental pollutants, can be achieved using various hydrogel-modified silica stationary phases.
These findings indicate that the CX3CR1-NF-κB axis plays an important role in silica-induced EMT and pulmonary fibrosis, and targeting CX3CR1 inhibits silica-induced epithelial-mesenchymal transition and pulmonary fibrosis in mice via the NF-κB signaling pathway, providing new insights for the prevention and treatment of silicosis.
Zhang J, Wang Y, Huo C, Jiao X, Zeng X, Li J, Zhu Z, Wang Y, Tian L, Wang Y. · Toxicology (2026)
In vitro two types of Cx3cr1 siRNA were used in RAW264.7 cells, and it showed that targeting CX3CR1 suppressed silica-induced EMT in MLE-12 cells.
Transcriptomic analysis revealed enrichment of the NF-κB pathway in vivo.
In vitro experiments further confirmed that combined inhibition of CX3CR1 and NF-κB synergistically alleviated silica-induced EMT.
We propose practical design and reporting rules to improve reproducibility and clinical readiness.
Vega-Baudrit JR, Corrales-Ureña YR. · Frontiers in bioengineering and biotechnology (2026)
Mesoporous silica nanoparticles (MSNs) offer a modular scaffold that can stabilize phenolics, tune spatiotemporal release, and program interfacial redox kinetics.
We define tumor redox sensitization as tumor-directed amplification of oxidative pressure and antioxidant shielding as restricted protection of non-malignant tissues from therapy-associated oxidative injury.
We discuss adsorption, covalent display, and stimuli-responsive gating, together with liabilities such as polyphenol pro-oxidant switching, protein corona-driven identity shifts, heterogeneous tumor exposure, safety and biodegradation constraints, and the absence of standardized redox readouts.
This review underscores the need for standardized testing protocols, comprehensive regulatory frameworks, and continued research into durable, food-grade biopolymer nanocoatings as viable replacements for conventional synthetic coating systems in food preservation and packaging.
Bharathi VSK, Jayas DS. · Foods (Basel, Switzerland) (2026)
Recent studies confirm that biopolymer-based nanocoatings, particularly those based on chitosan, cellulose nanofibers, and alginate, can significantly extend shelf life, reduce weight loss, retard oxidation, and maintain sensory quality.
Migration of nanomaterials from coatings into food systems is identified as a key safety concern.
Challenges including scalability, coating durability, substrate compatibility, and incomplete toxicological profiling are critically discussed.
17Systematische Übersichtn=12 · very small study2026
Country-specific variability in silica dust regulation and control likely contributes to prevalence, and future efforts should focus on linking exposure monitoring with policy and medical surveillance to reduce rates of this disabling but preventable disease.
Hua JT, Farah WH, Rose CS, Kellermeyer L, Zell-Baran LM. · BMC public health (2026)
The pooled prevalence of silicosis in 162,449 mineral miners from 26 countries was 17% (95% CI [13%, 22%]), based on low certainty due to high study heterogeneity (I2 = 99.6%).
Silicosis prevalence was highest in stone (20%; n = 12 studies), nonmetal (20%; n = 6), and metal (18%; n = 36) miners, with lower prevalence in sand/gravel (3%; n = 2) and mixed commodity miners (6%; n = 3), though studies were few and differences non-significant (p = 0.27).
In 43,282 miners from four countries, the cumulative incidence of silicosis ranged from 2 to 26%.
The present study based on cohort studies provide no evidence that occupational exposure to silica does increase the risk of leukemia.
Shao J, Wang S, Cheng H, Fu P, Zhang X. · BMC public health (2025)
The combined relative risk of leukemia associated with occupational silica exposure was determined to be 1.11 (95% CI: 0.93-1.33), with no significant differences observed across various industries, geographic regions, exposure periods, or study quality estimates.
After removing duplicates and excluding irrelevant studies, 22 studies were included in our analysis.
We utilized fixed-effects models in the implementation of our meta-analysis.
Future research should focus on elucidating underlying mechanisms to inform prevention and treatment strategies.
Lee S, Jo AR, Kim Y, Lee W, Ma X. · Journal of autoimmunity (2025)
Study quality was assessed using standard tools, and a random-effects model was used to estimate pooled odds ratio (OR) and 95 % confidence interval (CI), with subgroup analyses by dust type and disease category.
Dust exposure was significantly associated with increased autoimmune disease risk (OR 1.36, 95 % CI 1.13-1.59).
Both occupational (OR 1.18, 95 % CI 1.11-1.26) and environmental dust exposure (OR 1.12, 95 % CI 1.04-1.20) were linked to higher risk.
Such information would be very important for the development and optimization of drug delivery strategies based on mesoporous silica nanoparticles.
Kovtareva SY, Kopishev EE, Zhang H, Filippov SK. · European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (2025)
There is a lack of comprehensive reviews on that topic nowadays.
This paper overviews the latest publications on the physicochemical aspects of the interaction of mesoporous silica nanoparticles with drugs.
The review is focused primarily on a such parameters of the intermolecular binding between a drug and silica nanoparticle as a binding constant, enthalpy and entropy changes and experimental methods with the emphasis on the principles of thermodynamic parameters characterization.