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Slu3.0
SLU-PP-332 – Forschung
Überwiegend Mechanismus / Beobachtung
23 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu SLU-PP-332 sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen Studien, veröffentlicht 2023–2026.
Basierend auf 23 Studien
Konfidenz
Geringe Konfidenz
Nach Outcome
Endurance & exercise capacity (preclinical)Erhöhte Ausdauer und Fettoxidation bei Mäusen als pan-ERR-"Exercise-Mimetikum"; keinerlei Humandaten. · Nicht etabliert (keine Humandaten)
Überwiegend Mechanismus / Beobachtung4 Studien
Metabolic & fat oxidation (preclinical)
Überwiegend Mechanismus / Beobachtung3 Studien
Cardiac & heart failure (preclinical)
Überwiegend Mechanismus / Beobachtung3 Studien
Aging & healthspan (preclinical)
Überwiegend Mechanismus / Beobachtung3 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Aktives Forschungsgebiet
23 Studien in den letzten 5 Jahren
20232026
1Systematische Übersicht2026
We also review novel diagnostic techniques and therapies that target mitochondrial vulnerabilities to eliminate CSCs and provide better clinical outcomes.
Psvv C, Sunil S, Thuyyath N, Kokkanti RR, Lavudi K. · Frontiers in molecular biosciences (2026)
Over the past few years, significant progress has been made in targeting mitochondrial metabolism of CSCs, yet is still a developing area with tremendous therapeutic scope.
More research is required to identify mitochondrial vulnerabilities that are specific to therapy and then translate those findings into effective, precision-based cancer treatments.
We also review novel diagnostic techniques and therapies that target mitochondrial vulnerabilities to eliminate CSCs and provide better clinical outcomes.
There exists a reciprocal feed-forward transcriptional relationship between the LANCL proteins and transcriptional coactivators ERRα/PGC-1α, which may be leveraged using natural or synthetic LANCL agonists to enhance mitochondrial function across various clinical contexts.
Spinelli S, Bruschi M, Passalacqua M, Guida L, Magnone M, Sturla L, Zocchi E. · International journal of molecular sciences (2024)
Its ancient, cross-kingdom role enables ABA and its signaling pathway to regulate cell responses to environmental stimuli in various organisms, such as marine sponges, higher plants, and humans.
The ABA/LANCL1-2 hormone/receptor system emerges as a novel regulator of ERRα expression levels and transcriptional activity, mediated through the AMPK/SIRT1/PGC-1α axis.
There exists a reciprocal feed-forward transcriptional relationship between the LANCL proteins and transcriptional coactivators ERRα/PGC-1α, which may be leveraged using natural or synthetic LANCL agonists to enhance mitochondrial function across various clinical contexts.
This systematic-review examined the effects of SLU-PP-332.
Paik S, Um S, Kim IS, Park EJ, Kim KT, Basu J, Oh DC, Jo EK. · Autophagy (2026)
Additionally, multiple pathogens can evade host responses; thus, autophagy activation may inadvertently create favorable conditions for certain pathogens.
Exploring the intricate molecular interplay between natural products and autophagy in limiting infections may provide valuable insights that could inform the development of innovative host-directed antimicrobial treatments based on autophagy regulation.
These factors should be carefully considered in treatment planning for patients undergoing rotator cuff repair.
Sußiek J, Buchmann S, Beitzel K, Lappen S, Rehabilitation Committee of the German, Austrian and Swiss Shoulder and Elbow Society. · BMC musculoskeletal disorders (2026)
Improved tendon healing was associated with the upregulation of the growth factor Bone Morphogenetic Protein 5 (BMP5) and increased expression of collagen type III (COL3).
High preoperative expectations consistently correlated with better functional outcomes, whereas other psychological factors, such as concerns and fear avoidance, were associated with poorer outcomes.
Conclusion Evidence synthesized in this review underscores the importance of patient age, expectations, and the extent of the rotator cuff tear in influencing outcomes following rotator cuff repair.
This review explores the multifaceted roles of ERRα in breast cancer and highlights its translational potential as a molecular target for treating aggressive breast cancer subtypes.
Pradhan J, Samal AP, Khatoon U, Prusty M, Elangovan S. · Biochimica et biophysica acta. Reviews on cancer (2026)
The constitutively active orphan nuclear receptor, estrogen-related receptor α (ERRα), has emerged as a key regulator of tumor energy metabolism and a crucial driver of breast cancer progression.
The ERRα overexpression, frequently observed in aggressive subtypes, is strongly correlated with epithelial-mesenchymal transition, angiogenesis, invasion, metastasis, and therapy resistance.
Preclinical studies demonstrate that pharmacological inhibition or gene silencing of ERRα suppresses oncogenic signaling and enhances therapeutic sensitivity.
Collectively, the ongoing development of TRβ, ERRα, and LXR modulators exemplifies a new frontier in precision medicine, offering powerful approaches to reprogram dysregulated metabolic pathways with substantial promise for treating metabolic diseases.
Di Giovanni C, Lavecchia A. · Biomolecules (2026)
TRβ agonists, including resmetirom (MGL-3196) and VK2809, have demonstrated compelling efficacy in clinical trials for metabolic dysfunction-associated steatohepatitis (MASH), significantly reducing hepatic steatosis and fibrosis.
Next-generation hepatoselective modulators such as TG68 enhance tissue specificity and potency.
ERRα, a master regulator of mitochondrial biogenesis and energy metabolism, is targeted by inverse agonists (compound 29 , GSK5182) and agonists (JND003, SLU-PP-915), which show promise in ameliorating insulin resistance and promoting lipid oxidation in preclinical obesity models.
Clinical trials are needed to confirm their efficacy and safety in humans.
de Souza-Lima J, Astrosa-Martin BD, Galaz-Rodríguez CA, Silva-Bernal JE, Orellana-Pizarro LI, Mena-Díaz CA. · Revista medica de Chile (2026)
SLU-PP-332 and SLU-PP-915 reduce adiposity, improve glycemic control, and increase basal energy expenditure in obesity models, without evident toxicity.
Additionally, they restore mitochondrial function and reduce inflammation in aging kidneys.
Conclusions Pharmacological activation of ERRα/β/γ is a promising strategy as an exercise mimetic, with potential therapeutic applications in metabolic diseases, aging, and muscle-related conditions.
In conclusion, we propose that curcumin's ability to induce CYP3A4, suppress CYP19A1, inhibit EGF signaling, and promote detoxification and elimination of ATZ makes curcumin a promising candidate for a mechanism-based antidote to ATZ toxicity.
Wright PJ, Ilali J, Bu P. · Frontiers in endocrinology (2025)
Furthermore, curcumin may reduce ATZ's overall bioavailability.
ATZ and its metabolites undergo glutathione (GSH) conjugation followed by renal excretion.
Curcumin helps maintain the GSH pool and activates glutathione-S-transferase (GST) in rats, thereby potentially facilitating the detoxification and elimination of ATZ.
Elucidating NR interactions opens up new avenues for targeted therapies, emphasizing the critical need for further research in the evolving field of hepatology.
Antwi MB, Jennings A, Lefere S, Clarisse D, Geerts A, Devisscher L, De Bosscher K. · npj metabolic health and disease (2024)
We discuss their collective impact on hepatic lipid metabolism, inflammation, fibrosis, and glucose homeostasis.
We explore recent findings on dual NR crosstalk, via direct and indirect mechanisms, and discuss the potential of targeting receptor pathways using selective agonists, inverse agonists, antagonists, or specific modulators to combat MASLD and MASH.
Elucidating NR interactions opens up new avenues for targeted therapies, emphasizing the critical need for further research in the evolving field of hepatology.
This review summarized the available information on several important nuclear receptors in the pathophysiology of diabetic cardiomyopathy and discussed future perspectives on the application of nuclear receptors as targets for diabetic cardiomyopathy treatment.
Zheng Y, Xu Y, Ji L, San W, Shen D, Zhou Q, Meng G, Shi J, Chen Y. · Frontiers in pharmacology (2024)
Various studies have reported that nuclear receptors play a crucial role in cardiovascular diseases.
A recently conducted work highlighted the function of the nuclear receptor superfamily in the realm of metabolic diseases and their associated complications.
This review summarized the available information on several important nuclear receptors in the pathophysiology of diabetic cardiomyopathy and discussed future perspectives on the application of nuclear receptors as targets for diabetic cardiomyopathy treatment.
These findings provide guidance for further study on new ERRγ modulators.
Zheng Y, Du Y, Zhang H, Lv H, Yan Z, Dong N, Li Q, Wang T. · Current medicinal chemistry (2024)
The collision between residue Phe435 and the modulator is a key factor determining the activation or inhibition of ERRγ.
Although more than 20 agonists and inverse agonists of ERRγ have been reported, no clinical studies have been found in the literature.
This review summarizes the important relationship between ERRγ-related signaling pathways and diseases, research progress, and the structure-activity relationship of modulators.
Overall, the consequences of GPER activation are still an area of active research and the implication are not entirely clear.
Abbas MA, Al-Kabariti AY, Sutton C. · The Journal of steroid biochemistry and molecular biology (2024)
The complexity of the cross talk between GPER and other receptors including ER-β, ER-α36, Estrogen-related receptor α (ERRα) and androgen receptor has been discussed.
The potential utility of small molecules and phytoestrogens targeting GPER, adds valuable insights into its therapeutic potential.
This review holds promises in advancing our understanding of GPER role in ER-ɑ-negative breast cancer.
This review aims to summarize recent progress in developing new HDAC8 inhibitors that incorporate novel strategies and provide an overview of the clinical improvements associated with HDAC8 inhibitors.
Zhao Q, Liu H, Peng J, Niu H, Liu J, Xue H, Liu W, Liu X, Hao H, Zhang X, Wu J. · European journal of medicinal chemistry (2024)
Studies have demonstrated that HDAC8 plays essential roles in certain disease development, e.g., acute myeloid leukemia (AML), neuroblastoma, and X-Linked disorders.
Despite several HDAC8 inhibitors have been discovered, only one compound has progressed to clinical studies.
Recently, novel strategies targeting HDAC8 have emerged, including identifying innovative zinc-chelating groups (ZBG), developing multi-target drugs, and HDAC8 PROTACs.
This review delves into the literature highlighting the significance of ESRRA as a molecular target that may be important in the pathobiology of AMD, and discusses data available supporting the targeting of this receptor signaling pathway as a therapeutic option for AMD.
Somers FM, Malek G. · Current opinion in pharmacology (2024)
To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed.
The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor that regulates several AMD-associated pathogenic pathways.
However, it has not been investigated in detail in the ocular posterior pole during aging or in AMD.
Therefore, this review describes how ERRα-mediated cell migration contributes not only to tissue homeostasis but also to tumorigenesis and metastasis, and highlights the molecular and cellular mechanisms by which ERRα finely controls the cell migratory potential.
Vanacker JM, Forcet C. · Oncogene (2024)
ERRα is an orphan member of the nuclear hormone receptor superfamily of transcription factors and displays many biological functions.
ERRα is a global regulator of energy metabolism, and it is also highly involved in bone homeostasis, development, differentiation, immunity and cancer progression.
Importantly, in some instances, the regulation of these biological processes relies on the ability to orchestrate cell movements.
This review highlights new findings and provides a path to understanding the current ideas and future studies on ERRγ-mediated cellular activity.
Sadasivam N, Park WR, Choi B, Seok Jung Y, Choi HS, Kim DK. · Steroids (2024)
Moreover, ERRγ has proven crucial in regulating cellular and metabolic activity.
However, many functions mediated via ERRγ remain unknown and require further exploration.
Hence, considering the importance of ERRγ, this review focuses on the critical findings and interactions between ERRγ and co-regulators, agonists, and antagonists alongside its relationship with downstream and upstream signaling pathways and diseases.
These intriguing findings expand our fundamental understanding of the pathological basis of cilia defects, which is relevant for identifying future therapeutic targets for ciliopathies.
There is growing interest in understanding the mechanisms of ciliogenesis due to the profound consequences that follow from the absence of proper ciliary function, which include diseases that affect the renal, respiratory, reproductive, nervous, visual, and digestive systems, among others.
Now, a recent report has discerned new roles for the transcription factor estrogen-related receptor gamma a ( esrrγa) in ciliated cell ontogeny within the embryonic zebrafish kidney and other tissues.
Further, the team of researchers discovered that genetic ablation of murine homolog ERRγ in adult kidney epithelial cells led to shortened cilia, which precedes cystogenesis.
Foundational paper introducing SLU-PP-332 — the first synthetic compound with meaningful ERRα agonist activity (ERRβ/γ agonists existed before; ERRα had been hard to drug)
In mice, the compound induced the same acute aerobic-exercise transcriptional program in skeletal muscle that physical exercise triggers, and the response was ERRα-dependent
Enhanced exercise capacity (running performance) — the central 'exercise mimetic' result
Pharmacological exercise mimetics may be effective in the treatment of obesity and metabolic syndrome; SLU-PP-332, an ERR agonist, alleviated metabolic syndrome in mice.
Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, et al. · J Pharmacol Exp Ther (2024)
Direct follow-up testing SLU-PP-332 as a pharmacological exercise mimetic in a mouse metabolic-disease model
Enhanced fatty-acid/fat oxidation and alleviated features of diet-induced obesity and metabolic syndrome
Frames ERR agonism as a candidate approach for obesity and metabolic syndrome