1RCT2013
In the objective evaluation, the parameters of roughness were all decreased in the argireline group (p < 0.01), while no decrease was obvious in the placebo group (p > 0.05).
Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. · Am J Clin Dermatol (2013)
- Randomized, placebo-controlled topical trial: 60 subjects (3:1 Argireline:placebo) applied product to peri-orbital wrinkles twice daily for 4 weeks
- Objective silicone-replica wrinkle analysis showed all roughness parameters decreased significantly in the Argireline group (p < 0.01) and not in placebo
- Subjective total anti-wrinkle efficacy was 48.9% with Argireline vs 0% with placebo