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Si6.0
Soy Isoflavones – Forschung
Hilft wahrscheinlich
48 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Soy Isoflavones scheint in 10 von 13 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2004–2026 mit einer typischen Studiengröße von 421 Teilnehmenden.
Basierend auf 48 Studien · 29 Meta-Analysen · 5 RCTs · 23,498 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
10geholfen3unklar· 35 weitere ohne bewertete Effektdaten
Nach Outcome
Women's healthKann helfen, Wechseljahresbeschwerden wie Hitzewallungen und Stimmungsschwankungen zu bewältigen · 4-8 Wochen · Unterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen · Kann helfen, Menstruationsbeschwerden und PMS-Symptome zu verringern · 1-3 Zyklen
Bone healthUnterstützt die Knochenmineraldichte und die Skelettstärke · 8-12 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung5 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung4 Studien
Weight management
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung3 Studien
Men's vitalityPhytoöstrogene modulieren Östrogenrezeptoren und verringern Wechseljahresbeschwerden · 4-12 Wochen
Zu wenige bewertete Studien2 Studien
Liver health
Zu wenige bewertete Studien2 Studien
Depression & moodVerringerte Hitzewallungen und Wechseljahresbeschwerden · 4-12 Wochen
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 35 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
78%
über Studien hinweg
Untersuchte Personen
23k
typische Studie: 421 Personen
Stärkste Designs
34
29 gepoolt, 5 randomisiert
Zeigte Nutzen
77%
10/13 Studien
Wie lange Studien liefen
1–3 Monate
1
Untersuchte Populationen
Menopausal women6
Postmenopausal women5
Cancer patients2
Women with polycystic ovary syndrome1
Aktives Forschungsgebiet
37 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
200420152026
1PCOS symptoms improvementMeta-AnalyseCited 2×n=5,501 · very large study2025
Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.
Zhao G et al. · Reproductive biology and endocrinology : RB&E (2025)
Inositol significantly decreased total cholesterol and triglyceride levels, while curcumin was most effective in improving low-density and high-density lipoprotein cholesterol levels.
Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.
For improving obesity, sex hormone levels, inflammatory factors and oxidative stress indicators of PCOS patients, carnitine, chromium, and soy isoflavones are effective options, respectively.
2Measures of estrogenicityMeta-AnalyseCited 7×n=3,285 · very large study2025
Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with ...
Viscardi G et al. · Advances in nutrition (Bethesda, Md.) (2025)
Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with sustainable dietary patterns and guidelines.
This study was registered in PROSPERO as CRD42023439239.
3Systematische ÜbersichtCited 16×n=3,254 · very large study2025
There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS.
Robinson J et al. · Nutrition reviews (2025)
There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS.
However, more research using consistent protocols, procedures to minimize risk of bias, intention-to-treat analysis, and clearer reporting is required to provide conclusive nutritional recommendations for improving PMS-related psychological outcomes.
4Menopausal symptomsMeta-AnalyseCited 3×n=533 · large study2025
More trials should be conducted in the future to validate our findings.
Luan H et al. · PeerJ (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
In October 2024, we screened 2,099 articles, of which 12 were eligible for meta-analysis, and found that soy isoflavones were effective for treating menopausal symptoms (seven studies, 533 participants, Hedges' g = -0.25, 95% CI [-0.42 to -0.08], p = 0.00).
However, our results should be interpreted with caution owing to the small sample size.
More trials should be conducted in the future to validate our findings.
5Non-alcoholic fatty liver disease parametersMeta-AnalyseCited 64×n=2,173 · very large study2022
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
7Fasting blood glucoseMeta-AnalyseCited 35×n=1,529 · large study2016
Although the results displayed a significant tendency in favor of soy isoflavones, it appears that genistein alone played an important role in improving glucose metabolism due to its low heterogeneity.
Fang K et al. · Molecular nutrition & food research (2016)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The overall results showed that the average difference in fasting blood glucose values between women assigned to soy isoflavones and women in placebo groups was -0.22 mmol/L (95% CI: -0.38 to -0.07 mmol/L) under a random-effects model.
In addition, the effect of soy isoflavones on insulin was also significant: -0.43 μIU/mL (95% CI: -0.71 to -0.14 μIU/mL), as was the effect on homeostasis model assessment insulin resistance (HOMA-IR): -0.52 (95% CI: -0.76 to -0.28).
Although the results displayed a significant tendency in favor of soy isoflavones, it appears that genistein alone played an important role in improving glucose metabolism due to its low heterogeneity.
8Bone mineral densityMeta-AnalyseCited 11×n=63 · small study2024
This systematic review and meta-analysis suggests that isoflavone interventions, especially those containing genistein of at least 50 mg/day, can effectively enhance BMD in postmenopausal women.
Inpan R et al. · Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2024)
This systematic review and meta-analysis suggests that isoflavone interventions, especially those containing genistein of at least 50 mg/day, can effectively enhance BMD in postmenopausal women.
9Tumor area in hormone-dependent cancersMeta-AnalyseCited 5×n=30 · small study2024
Therefore, caution should be exercised when considering the intake of dietary isoflavones in female hormone-dependent cancer patients, particularly in the form of supplements.
Chakravarti B et al. · Phytotherapy research : PTR (2024)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
On the other hand, dietary isoflavones increased tumor area (Hedge's g = 1.136, 95% CI = 0.752 to 1.520, p = 0.000).
Dietary isoflavones have potential benefits and risks in female hormone-dependent cancers.
Therefore, caution should be exercised when considering the intake of dietary isoflavones in female hormone-dependent cancer patients, particularly in the form of supplements.
Although our results clearly showed soy isoflavones containing soy protein can have decreasing effect on inflammation in participants with chronic inflammatory disease, more large-scale and high quality interventional studies still need to be done to clarify our results.
Gholami A et al. · Journal of health, population, and nutrition (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Twenty-seven articles were involved in the systematic review and twenty-two articles with thirty-four effect sizes were considered for meta-analysis.
The overall estimates revealed that soy isoflavones containing soy protein significantly decreased serum levels of CRP in comparison with control group (weighted mean difference (WMD)= -0.49 mg/L; 95% confidence interval (CI): -0.74, -0.25; P = 0 < 0.001).
Although our results clearly showed soy isoflavones containing soy protein can have decreasing effect on inflammation in participants with chronic inflammatory disease, more large-scale and high quality interventional studies still need to be done to clarify our results.
11Serum concentration of leptinMeta-Analysen=421 · medium study2022
Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin.
Gholami A et al. · Clinical nutrition ESPEN (2022)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A pooled analysis revealed that the combination of soy isoflavones and soy protein had a borderline non-significant on serum concentration of leptin (weighted mean difference (WMD): -1.03 ng/ml, 95% confidence interval (CI): -2.11, 0.05 ng/ml).
Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin.
However, making firm conclusion needs more studies on participants with different health condition, and different soy isoflavones doses and intervention duration.
Still, the inconsistent results across the included RCTs require further clinical research to establish optimal dosage and duration.
Ranneh Y et al. · Nutrients (2024)
Most studies on silymarin showed a reduction in liver enzymes and lipid profile; however, no changes were observed in inflammatory cytokine levels.
The dietary supplementation of hesperidin and naringenin or green tea extract caused improvements in liver enzyme, lipid profile, and inflammatory cytokine, while genistein supplementation did not modulate blood lipid profile.
In conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD.
13Cancer-specific mortality and recurrenceMeta-AnalyseCited 15×2024
Soy, enterolactone, and green tea demonstrated significant risk reductions in outcomes following breast cancer.
van Die MD et al. · JNCI cancer spectrum (2024)
Groß Nutzen
← SchlechterKein EffektBesser →
Soy protein and products were inversely associated with cancer-specific mortality for estrogen receptor-positive disease (HR = 0.75, 95% CI = 0.60 to 0.92).
An inverse association was observed for serum or plasma enterolactone, measured prediagnosis and early postdiagnosis, with cancer-specific mortality (HR = 0.72, 95% CI = 0.58 to 0.90) and all-cause mortality (HR = 0.69, 95% CI = 0.57 to 0.83).
There was a 44% reduced risk of recurrence with prediagnostic green tea for stage I and II breast cancer (HR = 0.56, 95% CI = 0.38 to 0.83).
14Menopausal symptoms and quality of lifeMeta-AnalyseCited 5×2024
According to the results of the analysis, soy isoflavones had no effect on menopausal symptoms (vasomotor, psychosocial, physical, sexual, and urogenital complaints) and quality of life in climacteric women but did reduce the level of depression.
Gençtürk N et al. · Explore (New York, N.Y.) (2024)
According to the results of the analysis, soy isoflavones had no effect on menopausal symptoms (vasomotor, psychosocial, physical, sexual, and urogenital complaints) and quality of life in climacteric women but did reduce the level of depression.
There was a high risk of conflict of interest in the included studies.
15Clinical outcomes in diabetic nephropathyMeta-AnalyseCited 6×2024
Moderate to low amounts of evidence suggest that supplementation with probiotics, vitamin D, soy isoflavones, coenzyme Q10, dietary polyphenols, antioxidant vitamins, or salt-restricted diets may significantly improve clinical outcomes in patients with DN.
Cai L et al. · Frontiers in endocrinology (2024)
Moderate-quality evidence suggested that probiotic supplementation could significantly improve blood urea nitrogen (BUN), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels in DN patients.
Low-quality evidence indicated that probiotic supplementation significantly improved the serum creatinine concentration, urinary albumin-creatinine ratio (UACR), fasting blood glucose (FBG), HbA1c and high-density lipoprotein cholesterol (HDL-C) in DN patients.
In addition, low-quality evidence suggested that a salt restriction diet could significantly improve the creatinine clearance rate (CrCl) in patients with DN.
Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.
Barańska A et al. · Nutrients (2021)
Subgroup analysis and meta-regression were performed to assess the modifiers of treatment response.
In total, in the analysis studies, 2305 postmenopausal women took part.
Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.
17Hot flashes and menopausal symptomsMeta-AnalyseCited 166×n=62 · small study2016
This meta-analysis of clinical trials suggests that composite and specific phytoestrogen supplementations were associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats.
Franco OH et al. · JAMA (2016)
There was substantial heterogeneity in quality across the available studies, and 46 (74%) of the included randomized clinical trials demonstrated a high risk of bias within 3 or more areas of study quality.
This meta-analysis of clinical trials suggests that composite and specific phytoestrogen supplementations were associated with modest reductions in the frequency of hot flashes and vaginal dryness but no significant reduction in night sweats.
However, because of general suboptimal quality and the heterogeneous nature of the current evidence, further rigorous studies are needed to determine the association of plant-based and natural therapies with menopausal health.
19IL-6 and TNF-α concentrationsMeta-AnalyseCited 6×2022
In conclusion, our meta-analysis did not confirm any significant effect on serum concentration of IL-6 and TNF-α among post-menopausal women.
Gholami A et al. · Clinical and experimental pharmacology & physiology (2022)
The mean change from baseline and its standard deviation (SD) for intervention and comparison groups were used to calculate the effect size.
In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose ≤87 mg/days, cross-over design, weak quality, and studies on participants who had health risk factors or diseases.
The serum concentration of TNF-α increased in studies with cross-over design, intervention duration ≤56 days, and body mass index (BMI) >27, and in studies that were conducted on at-risk or sick participants.
Further multicenter studies based on larger and longer duration studies are necessary to determine their beneficial effect on glucose and lipid metabolism.
Barańska A et al. · Nutrients (2021)
Weighted mean differences and 95% confidence intervals (CI) were calculated by using random-effect models.
At the same time, a meta-analysis of the included studies revealed statistically insignificant reduction in fasting glucose, insulin, HbA1c, and HOMA-IR (changes in glucose metabolism) after consumption of soy isoflavones.
The observed ability of both extracted isoflavone and soy protein with isoflavones to modulate the lipid profile suggests benefits in preventing cardiovascular events in diabetic subjects.