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Si6.0
Soy Isoflavones – Forschung
Hilft wahrscheinlich
274 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Soy Isoflavones scheint in 13 von 15 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1992–2026 mit einer typischen Studiengröße von 533 Teilnehmenden.
Basierend auf 274 Studien · 55 Meta-Analysen · 202 RCTs · 32,929 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
13geholfen2unklar· 259 weitere ohne bewertete Effektdaten
Nach Outcome
Women's healthKann helfen, Wechseljahresbeschwerden wie Hitzewallungen und Stimmungsschwankungen zu bewältigen · 4-8 Wochen · Unterstützt einen gesunden Östrogenstoffwechsel und das hormonelle Gleichgewicht · 4-8 Wochen · Kann helfen, Menstruationsbeschwerden und PMS-Symptome zu verringern · 1-3 Zyklen
Hilft wahrscheinlich256 Studien
Cholesterol & lipids
Hilft vermutlich49 Studien
Bone healthUnterstützt die Knochenmineraldichte und die Skelettstärke · 8-12 Wochen
Men's vitalityPhytoöstrogene modulieren Östrogenrezeptoren und verringern Wechseljahresbeschwerden · 4-12 Wochen
Überwiegend Mechanismus / Beobachtung12 Studien
Liver health
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Skin healthVerbesserung feiner Linien in postmenopausalen RCTs (östrogene Wirkung) · 12-24 Wochen · Verbesserte Hautelastizität bei postmenopausalen Frauen · 12-24 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Depression & moodVerringerte Hitzewallungen und Wechseljahresbeschwerden · 4-12 Wochen
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 36 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
78%
über Studien hinweg
Untersuchte Personen
33k
typische Studie: 533 Personen
Stärkste Designs
257
55 gepoolt, 202 randomisiert
Zeigte Nutzen
87%
13/15 Studien
Wie lange Studien liefen
1–3 Monate
1
Untersuchte Populationen
Postmenopausal women5
Menopausal women3
NAFLD patients2
Men2
Stetige Forschung
55 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199220092026
1PCOS symptoms improvementMeta-Analysen=5,501 · very large study2025
Einfach gesagt: Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.
Zhao G et al. · Reproductive biology and endocrinology : RB&E (2025)
Inositol significantly decreased total cholesterol and triglyceride levels, while curcumin was most effective in improving low-density and high-density lipoprotein cholesterol levels.
Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.
For improving obesity, sex hormone levels, inflammatory factors and oxidative stress indicators of PCOS patients, carnitine, chromium, and soy isoflavones are effective options, respectively.
2Systematische Übersichtn=3,254 · very large study2025
Einfach gesagt: There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS.
Robinson J et al. · Nutrition reviews (2025)
There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS.
However, more research using consistent protocols, procedures to minimize risk of bias, intention-to-treat analysis, and clearer reporting is required to provide conclusive nutritional recommendations for improving PMS-related psychological outcomes.
3Measures of estrogenicityMeta-Analysen=3,285 · very large study2025
Einfach gesagt: Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with ...
Viscardi G et al. · Advances in nutrition (Bethesda, Md.) (2025)
Addressing public health concerns may promote soy foods as high-quality plant protein sources with low environmental impact and cost, particularly benefiting postmenopausal women and aligning with sustainable dietary patterns and guidelines.
4Menopausal symptomsMeta-Analysen=533 · large study2025
Einfach gesagt: More trials should be conducted in the future to validate our findings.
Luan H et al. · PeerJ (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
In October 2024, we screened 2,099 articles, of which 12 were eligible for meta-analysis, and found that soy isoflavones were effective for treating menopausal symptoms (seven studies, 533 participants, Hedges' g = -0.25, 95% CI [-0.42 to -0.08], p = 0.00).
However, our results should be interpreted with caution owing to the small sample size.
More trials should be conducted in the future to validate our findings.
5Non-alcoholic fatty liver disease treatmentMeta-Analysen=2,173 · very large study2022
Einfach gesagt: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
7Fasting blood glucoseMeta-Analysen=1,529 · large study2016
Einfach gesagt: Although the results displayed a significant tendency in favor of soy isoflavones, it appears that genistein alone played an important role in improving glucose metabolism due to its low heterogeneity.
Fang K et al. · Molecular nutrition & food research (2016)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The overall results showed that the average difference in fasting blood glucose values between women assigned to soy isoflavones and women in placebo groups was -0.22 mmol/L (95% CI: -0.38 to -0.07 mmol/L) under a random-effects model.
In addition, the effect of soy isoflavones on insulin was also significant: -0.43 μIU/mL (95% CI: -0.71 to -0.14 μIU/mL), as was the effect on homeostasis model assessment insulin resistance (HOMA-IR): -0.52 (95% CI: -0.76 to -0.28).
Although the results displayed a significant tendency in favor of soy isoflavones, it appears that genistein alone played an important role in improving glucose metabolism due to its low heterogeneity.
Einfach gesagt: Meta-analysis of the ten studies that reported hot flush data indicated that phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).
Chen MN et al. · Climacteric (2015)
15 RCTs meeting the inclusion criteria were included; intervention periods ranged from 3 to 12 months.
Phytoestrogens result in a significantly greater reduction in hot flush frequency compared to placebo (pooled mean difference = 0.89, p < 0.005).
Meta-analysis of the five studies that reported side-effect data showed no significant difference between the two groups.
9Male reproductive hormonesMeta-AnalyseCited 41×n=752 · large study2021
Einfach gesagt: Sub-analysis of the data according to isoflavone dose and study duration also showed no effect.
Reed KE et al. · Reproductive toxicology (Elmsford, N.Y.) (2021)
Moved here from `red-clover` on 2026-08-24: it is a SOY study and the clinical ruling is that soy-isoflavone evidence does not transfer to red clover.
Sub-analysis of the data according to isoflavone dose and study duration also showed no effect.
This updated and expanded meta-analysis indicates that regardless of dose and study duration, neither soy protein nor isoflavone exposure affects TT, FT, E2 or E1 levels in men.
Einfach gesagt: Although our results clearly showed soy isoflavones containing soy protein can have decreasing effect on inflammation in participants with chronic inflammatory disease, more large-scale and high quality interventional studies still need to be done to clarify our results.
Gholami A et al. · Journal of health, population, and nutrition (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Twenty-seven articles were involved in the systematic review and twenty-two articles with thirty-four effect sizes were considered for meta-analysis.
The overall estimates revealed that soy isoflavones containing soy protein significantly decreased serum levels of CRP in comparison with control group (weighted mean difference (WMD)= -0.49 mg/L; 95% confidence interval (CI): -0.74, -0.25; P = 0 < 0.001).
Although our results clearly showed soy isoflavones containing soy protein can have decreasing effect on inflammation in participants with chronic inflammatory disease, more large-scale and high quality interventional studies still need to be done to clarify our results.
17Serum concentration of leptinMeta-Analysen=421 · medium study2022
Einfach gesagt: Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin.
Gholami A et al. · Clinical nutrition ESPEN (2022)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A pooled analysis revealed that the combination of soy isoflavones and soy protein had a borderline non-significant on serum concentration of leptin (weighted mean difference (WMD): -1.03 ng/ml, 95% confidence interval (CI): -2.11, 0.05 ng/ml).
Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin.
However, making firm conclusion needs more studies on participants with different health condition, and different soy isoflavones doses and intervention duration.