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SPM6.2
Spearmint – Forschung
Überwiegend Mechanismus / Beobachtung
18 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Spearmint sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2007–2026 mit einer typischen Studiengröße von 52 Teilnehmenden.
Basierend auf 18 Studien · 10 RCTs · 575 Teilnehmende insgesamt
Konfidenz
Mittlere Konfidenz
Nach Outcome
Cognitive functionVerbessertes Arbeitsgedächtnis und räumliches Gedächtnis bei Erwachsenen mit altersbedingter Gedächtnisbeeinträchtigung · 4–12 Wochen
Überwiegend Mechanismus / Beobachtung8 Studien
PCOS, hirsutism & hormonalSignifikante Reduktion des freien Testosteronspiegels; Verbesserung des LH/FSH-Verhältnisses · 4–8 Wochen · Reduktion androgenbedingter Symptome; mögliche Stimmungs- und Hormonstabilisierung · 4–8 Wochen
Überwiegend Mechanismus / Beobachtung4 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
InflammationVerringerte Gelenkschmerzen und Steifigkeit bei Kniearthrose · 8–16 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Men's vitalityVerringerte Androgenspiegel und verbessertes Gonadotropin-Profil bei Frauen mit PCOS · 4–8 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Focus & attentionVerbesserte anhaltende Aufmerksamkeit; die Auswirkungen auf Reaktionsgeschwindigkeit/Beweglichkeit sind weniger konsistent · 4–8 Wochen
Zu wenige bewertete Studien2 Studien
Joint pain & arthritisVerringerte Knieschmerzen und Steifigkeit bei Arthrose-Patienten · 8–16 Wochen
Zu wenige bewertete Studien1 Studie
Skin healthVerringerung der Anzahl von Akneläsionen und des Akne-Bewertungsscores bei topischer Anwendung · 4–8 Wochen
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
6 Studien in den letzten 5 Jahren
200720162026
1Systematische Übersicht2026
They help reduce reliance on synthetic chemicals and minimize the potential for resistance development.
Krajewska A, Azeez G, Ebadollahi A, Kalemba D, Synowiec A. · Molecules (Basel, Switzerland) (2026)
The biological activity of these EOs is significantly influenced by their specific composition, which varies among plant species and chemotypes.
While EOs' inherent volatility limits direct field application, this challenge is being successfully addressed by innovative formulation technologies, such as nanoemulsification and encapsulation, which enhance stability, bioavailability, and targeted delivery.
In conclusion, carvone-rich EOs offer effective, environmentally low-risk agents for the integrated management of pathogens, pests, and weeds in sustainable agriculture.
Results indicate that Indian pennywort, Sea buckthorn, Spearmint oil and ginger are beneficial in mitigating RINV.
Palatty PL et al. · International journal of radiation biology (2024)
Results indicate that Indian pennywort, Sea buckthorn, Spearmint oil and ginger are beneficial in mitigating RINV.
Also, of the four plants investigated in preclinical models of study, mint oil and ginger seem to be more useful and merit structured systematic translational studies to ascertain the benefit of these two agents.
3Systematische Übersichtn=29 · very small study2024
Registration PROSPERO no.
Li S, Huang Y, Xie H. · PloS one (2024)
Results Our network meta-analysis included 29 studies, and the results showed that Chinese herb (OR: 0.39, 95% CI: 0.2-0.75) and Miswak (OR: 0.27, 95% CI: 0.07-0.91) were more effective in reducing VAP incidence than CHX.
Simultaneously, Matrica® demonstrates a significant reduction in microbial counts but does not exhibit a significant advantage in lowering the incidence of VAP.
Therefore, we identify Miswak and Matrica® as promising herbal oral care products with the potential to replace CHX.
This review will, therefore, contribute to the rational and economic exploration of spearmint aromatic molecules as natural and safe alternative therapeutics.
Zhang LL et al. · Food & function (2022)
Besides their traditional use, these aromatic molecules have attracted great interest in other application fields (e.g., medicine, agriculture, food, and beverages) especially due to their antimicrobial, antioxidant, insecticidal, antitumor, anti-inflammatory and antidiabetic activities.
This review presents the sources, properties, synthesis and application of spearmint aromatic molecules.
Furthermore, this review focuses on the biological properties so far described for these compounds, their therapeutic effect on some diseases, and future directions of research.
A comprehensive evidence-based review of spearmint covering pharmacology, interactions, adverse effects, and dosing, synthesizing available scientific literature and expert opinion.
Ulbricht C et al. · Journal of dietary supplements (2010)
Spearmint (Mentha spicata) has demonstrated anti-androgenic, antimicrobial, and antioxidant properties in available literature.
Clinical evidence supports use for hirsutism management via reduction of free testosterone in women.
The review identified spearmint's rosmarinic acid as a key bioactive compound with anti-inflammatory and neuroprotective potential.
Free and total testosterone levels were significantly reduced over the 30 day period in the spearmint tea group (p < 0.05), and LH and FSH also increased (p < 0.05).
Grant P et al. · Phytotherapy research : PTR (2010)
Forty-one of 42 patients completed this 30-day RCT comparing spearmint tea twice daily to placebo herbal tea.
Free and total testosterone were significantly reduced in the spearmint tea group compared to placebo (p < 0.05).
LH and FSH levels increased significantly in the spearmint group, indicating modulation of the hypothalamic-pituitary-gonadal axis.
Supplementation with spearmint extract significantly improved working memory in men and women with age-associated memory impairment compared to placebo.
Herrlinger KA et al. · Journal of alternative and complementary medicine (New York, N.Y.) (2018)
Adults with age-associated memory impairment receiving 900 mg/day spearmint extract showed significant improvements in spatial working memory.
The 90-day RCT demonstrated benefits in both sexes, suggesting broad cognitive applicability.
Rosmarinic acid was identified as a key bioactive compound mediating neuroprotective effects.
Spearmint extract supplementation significantly improved sustained attention and accuracy in a cognitively demanding task compared to placebo in healthy adults.
Falcone PH et al. · Nutrition research (New York, N.Y.) (2019)
Spearmint extract significantly improved reactive agility compared to placebo in a randomized controlled trial, supporting its nootropic potential for sports performance applications.
Falcone PH et al. · Journal of the International Society of Sports Nutrition (2018)
Supplementation with a standardized spearmint extract significantly improved reactive agility scores compared to placebo.
Improvements in choice reaction time and agility were observed after 4 weeks of supplementation.
Results suggest spearmint extract benefits extend beyond memory to include real-world executive function and reaction speed.
11Safety and tolerabilityRCTCited 4×n=103 · medium study2017
Ingestion of both 600 and 900 mg/day of dried aqueous spearmint extract for 90 days had no effect on plasma levels of follicular stimulating hormone, luteinizing hormone, thyroid stimulating hormone, or other safety parameters.
Lasrado JA et al. · Regulatory toxicology and pharmacology : RTP (2017)
600 and 900 mg/day of standardized spearmint extract for 90 days was safe and well-tolerated in healthy adults with age-associated memory impairment.
No significant effects on FSH, LH, or TSH were observed at these doses, indicating hormonal safety in a mixed-sex population.
No severe adverse events were reported; the frequency of adverse events did not differ significantly between treatment and placebo groups.
However, more studies with larger sample sizes and longer durations are required to confirm this effect.
Saeidi S, Ghanadian SM, Poostiyan N, Soltani R. · Journal of cosmetic dermatology (2024)
Methods Patients with mild to moderate facial acne who met the inclusion criteria were randomly assigned to either drug (B. integerrima extract/spearmint essential oil topical solution) or control (clindamycin 1% topical solution) groups.
Topical B.integerrima root extract/spearmint essential oil significantly reduced the number of lesions (27.33 ± 26.17 vs. 21.58 ± 21.10; p < 0.001) and mGAGS (18.76 ± 8.61 vs. 13.87 ± 8.14; p < 0.001) at the end of the intervention.
However, there was no significant difference between the two groups regarding the number of lesions (p = 0.906) and mGAGS (p = 0.882).
13Nausea and vomiting symptomsSystematische ÜbersichtCited 17×2020
Herbal medicines such as matricaria chamomilla, elettaria cardamomum, pomegranate and spearmint syrup, lemon provide safe and effective medical alternatives for treating pregnant women with mild to moderate nausea and vomiting of pregnancy.
Khorasani F et al. · Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology (2020)
Spearmint syrup was identified as one of several herbal alternatives showing efficacy for mild-to-moderate pregnancy nausea and vomiting.
Ginger demonstrated the strongest evidence across all reviewed herbal interventions for nausea and vomiting of pregnancy.
Mentha preparations showed variable results, with some positive effects on nausea but not consistently on vomiting.
After treatment with spearmint teas, there was a significant decrease in free testosterone and increase in luteinizing hormone, follicle-stimulating hormone and estradiol.
Akdoğan M et al. · Phytotherapy research : PTR (2007)
Twenty-one hirsute women (12 PCOS, 9 idiopathic) consumed spearmint tea twice daily for 5 days in the follicular phase.
High-rosmarinic acid spearmint tea significantly reduced knee osteoarthritis pain and stiffness compared to commercially available spearmint tea over 16 weeks.
Connelly AE et al. · Journal of medicinal food (2014)
Sixty-two participants with medically diagnosed knee osteoarthritis consumed high-rosmarinic acid or commercial spearmint tea twice daily for 16 weeks.
The high-rosmarinic acid spearmint group showed significantly greater reductions in pain and stiffness scores compared to commercial spearmint.
Physical function improvements were noted in the high-rosmarinic acid group at 16 weeks.
Magnitude-based inferences indicated that differences between PSE and PL in jump power, reactive agility, eye-hand coordination, and cognition were unclear. However, subjective feelings of energy, alertness, and focus were very likely, likely, and possibly better for PSE than PL, respectively.
Ostfeld I et al. · Journal of special operations medicine : a peer reviewed journal for SOF medical professionals (2018)
Ten operators from an elite counterterrorism unit ingested 900 mg/day spearmint extract or placebo for 17 days, tested before and within 1 hour of a high-risk tactical operation while sleep deprived.
Differences between spearmint extract and placebo in jump power, reactive agility, eye-hand coordination, and cognition were unclear (no conclusive objective benefit).
Subjective feelings of energy, alertness, and focus were better for the spearmint extract group than placebo.
Peppermint (Mentha piperita) essential oil with high levels of menthol/menthone and characteristic in vitro cholinergic inhibitory, calcium regulatory and GABAA/nicotinic receptor binding properties, beneficially modulated performance on demanding cognitive tasks and attenuated the increase in mental fatigue associated with extended cognitive task performance in healthy adults.
Kennedy D et al. · Nutrients (2018)
Spearmint and peppermint (Mentha spicata/piperita) essential oils were pre-screened for neurotransmitter receptor binding and acetylcholinesterase (AChE) inhibition; peppermint had the most promising in vitro profile and was selected for the human trial.
In a double-blind, placebo-controlled crossover study, 24 participants consumed single oral doses of the peppermint essential oil.
The 100 µL dose improved performance on the Rapid Visual Information Processing task and attenuated mental fatigue on a demanding subtraction task.
18Herbal medicine use patterns and safetySystematische ÜbersichtCited 41×2014
Spearmint and other mint-family herbs are among the most commonly used herbal medicines by elderly patients, with a generally favorable safety profile but potential for interactions with conventional medications.
de Souza Silva JE et al. · Archives of gerontology and geriatrics (2014)
Spearmint was identified as one of the most frequently consumed herbal medicines in elderly populations globally.
The review highlighted the importance of considering herb-drug interactions in elderly patients on polypharmacy regimens.
Overall safety of mint family herbs was found to be acceptable, with most adverse effects being mild and transient.