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Spd4.2
Spermidine – Forschung
Hilft vermutlich
39 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
Spermidine half in etwa der Hälfte (2/4) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen randomisierten Studien, veröffentlicht 2009–2026 mit einer typischen Studiengröße von 85 Teilnehmenden.
Basierend auf 39 Studien · 14 RCTs · 5,524 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
2geholfen1unklar1nicht geholfen· 35 weitere ohne bewertete Effektdaten
Nach Outcome
Longevity & agingGeringere Sterblichkeit nur in Beobachtungskohorten; keine Longevity-Studie am Menschen · Fortlaufend
Hilft vermutlich37 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung8 Studien
Neuroprotection & brain agingDie größte RCT fand keinen Nutzen für das Gedächtnis; kleine Pilotstudien uneinheitlich · Fortlaufend
Überwiegend Mechanismus / Beobachtung6 Studien
InflammationVeränderungen von Entzündungsmarkern nur in kleinen Pilotstudien beobachtet · Fortlaufend
Überwiegend Mechanismus / Beobachtung6 Studien
Heart & blood pressure
Überwiegend Mechanismus / Beobachtung4 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung3 Studien
Immune support
Zu wenige bewertete Studien2 Studien
Glucose & metabolicVerschiebungen kardiometabolischer Biomarker in einer einzelnen kleinen Pilotstudie; nicht bestätigt · Fortlaufend
Zu wenige bewertete Studien1 Studie
Fertility & reproductive
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 22 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
5,524
typische Studie: 85 Personen
Stärkste Designs
14
0 gepoolt, 14 randomisiert
Zeigte Nutzen
50%
2/4 Studien
Wie lange Studien liefen
1–3 Monate
2
3+ Monate
1
Untersuchte Populationen
General population2
Adults2
Patients with abdominal aortic aneurysm1
Older adults1
Aktives Forschungsgebiet
29 Studien in den letzten 5 Jahren
200920172026
1Gut dysbiosis in abdominal aortic aneurysmSystematische Übersicht2024
Einfach gesagt: With our expanding knowledge of the downstream pathogenic mechanisms of gut dysbiosis, novel therapeutics such as short-chain fatty acids and spermidine, as well as prognostic biomarkers such as TM...
Chui ESH et al. · Asian journal of surgery (2024)
With our expanding knowledge of the downstream pathogenic mechanisms of gut dysbiosis, novel therapeutics such as short-chain fatty acids and spermidine, as well as prognostic biomarkers such as TMAO have yielded promising preclinical results.
In conclusion, there is strong evidence corroborating the role of gut dysbiosis in the pathogenesis of AAA, wherein its therapeutic and prognostic potential deserves further exploration.
Einfach gesagt: A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.
Gruendler R et al. · Molecules (Basel, Switzerland) (2020)
Currently, there are no therapy options available that halt AD progression.
The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD.
A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.
Einfach gesagt: Bringing together current knowledge on the significance of spermidine in both plants and humans, this review aims to trace its journey From Farm to Pharm, highlighting its importance for sustainable crop production, improved nutrition, and emerging pharmacological applications.
Blagojević BD, Brunel-Muguet S, Šućur R, Mladenov V, Balaž I, Vollmann J, Fotopoulos V, Mäder K. · NPJ science of food (2026)
From the aspect of human health, spermidine is mainly studied for healthy ageing properties and has been associated with cardioprotective, neuroprotective, and anti-cancerogenic effects.
On the other hand, being present in all plants, spermidine is essential for growth, development, and stress adaptation.
Endogenously or when exogenously applied, spermidine can help plants adapt to harsh climate change conditions.
5Intestinal aging and polyamine availabilityÜbersicht2026
Einfach gesagt: In conclusion, modulating the diet-microbiota-polyamine axis represents a promising strategy to promote healthy intestinal aging, meriting deeper mechanistic exploration and validation through clinical studies.
Mafe AN et al. · Nutrients (2026)
It further discusses how age-associated dysbiosis disrupts these interactions and evaluates nutritional and microbial-based strategies such as fermented foods, prebiotics, and probiotics that may enhance polyamine availability and restore gut homeostasis.
From the standpoint of food microbiology and human physiology, this synthesis underscores the translational potential of targeting microbial polyamine production through diet-based interventions.
This article presents a narrative review synthesizing experimental, animal, and emerging human evidence on microbial and dietary polyamines in intestinal aging.
6Colorectal adenomatous polyp riskBeobachtungsstudien=1,164 · large study2012
Einfach gesagt: This study showed a role for dietary polyamines in colorectal adenoma risk.
Vargas AJ et al. · The American journal of clinical nutrition (2012)
Groß Schaden
← SchlechterKein EffektBesser →
A dietary intake of polyamines above the median amount in the study population was associated with 39% increased risk of colorectal adenoma at follow-up (adjusted OR: 1.39; 95% CI: 1.06, 1.83) in the pooled sample.
In addition, younger participants (OR: 1.94; 95% CI: 1.23, 3.08), women (OR: 2.43; 95% CI: 1.48, 4.00), and ODC GG genotype carriers (OR: 1.59; 95% CI: 1.00, 2.53) had significantly increased odds of colorectal adenoma if they consumed above-median polyamine amounts.
This study showed a role for dietary polyamines in colorectal adenoma risk.
9Mnemonic discrimination performanceRCTn=100 · medium study2022
Einfach gesagt: In this randomized clinical trial, longer-term spermidine supplementation in participants with subjective cognitive decline did not modify memory and biomarkers compared with placebo.
Schwarz C et al. · JAMA network open (2022)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Could be chance
A total of 100 participants (51 in the spermidine group and 49 in the placebo group) were included in the analysis (mean [SD] age, 69 [5] years; 49 female participants [49%]).
Over 12 months, no significant changes were observed in mnemonic discrimination performance (between-group difference, -0.03; 95% CI, -0.11 to 0.05; P = .47) and secondary outcomes.
In this randomized clinical trial, longer-term spermidine supplementation in participants with subjective cognitive decline did not modify memory and biomarkers compared with placebo.
Bruno G, La Monica M, Ziegenfuss TN · Altern Ther Health Med (2025)
13Pilotstudien=5 · very small study2024
Einfach gesagt: Intake of the combined supplements showed they were bioavailable and increased in plasma in a dose-dependent manner and provide preliminary data showing enhanced plasma anti-inflammatory and antiox...
Rhodes CH et al. · Nutrition research (New York, N.Y.) (2024)
Intake of the combined supplements showed they were bioavailable and increased in plasma in a dose-dependent manner and provide preliminary data showing enhanced plasma anti-inflammatory and antioxidant functions.
Einfach gesagt: The results of this study reveal multiple functionalities and immunological pathways affected by PF in humans, identify candidates for the development of fasting mimetic compounds, and uncover targets for investigation in longevity research.
Rhodes CH et al. · The American journal of clinical nutrition (2023)
Furthermore, we found that these metabolites and their combination significantly extended the median lifespan of C. elegans by as much as 96%.
The results of this study reveal multiple functionalities and immunological pathways affected by PF in humans, identify candidates for the development of fasting mimetic compounds, and uncover targets for investigation in longevity research.
15Biomarkers of autophagy and cardiometabolic healthPilotstudien=12 · very small study2025
Einfach gesagt: This pilot study found that 3.3 mg/day of spermidine from Miricell® rice germ extract tends to improve biomarkers of autophagy, neuroprotection, and cardiometabolic health.
Bruno G et al. · Alternative therapies in health and medicine (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Compared to baseline, only the 3.3 mg dose of spermidine from Miricell® increased Beclin-1 by 7.3%, ULK-1 by 13.4%, and BDNF by 12.1%.
Compared to baseline, the same dose resulted in a 20.8% decrease in hs-CRP, a 20.1% decrease in VLDL, and a 26.9% decrease in triglycerides.
This pilot study found that 3.3 mg/day of spermidine from Miricell® rice germ extract tends to improve biomarkers of autophagy, neuroprotection, and cardiometabolic health.
16Cognitive performance improvementRCTn=85 · small study2021
Einfach gesagt: By comparison, the group which had a lower spermidine intake showed consistent or declining cognitive performance.
Pekar T et al. · Wiener klinische Wochenschrift (2021)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Blood samples were taken for the determination of spermidine concentration and measurement of metabolic parameters.
The results demonstrated a clear correlation between the intake of spermidine and the improvement in cognitive performance in subjects with mild and moderate dementia in the group treated with the higher spermidine dosage.
The most substantial improvement in test performance was found in the group of subjects with mild dementia with an increase of 2.23 points (p = 0.026) in the mini mental state examination (MMSE) and 1.99 (p = 0.47) in phonematic fluidity.
Einfach gesagt: In this pilot trial, nutritional spermidine was associated with a positive impact on memory performance in older adults with subject cognitive decline.
Wirth M et al. · Cortex (2018)
Phase IIa pilot trial in 30 cognitively intact older adults (60-80 years) with subjective cognitive decline given a spermidine-rich plant extract for 3 months.
Memory performance was moderately enhanced in the spermidine group versus placebo (Cohen's d = .77; 95% CI crossed zero).
Mnemonic discrimination ability improved in the spermidine group with a medium effect size; no similar effect in placebo.
18Disease progression predictionRCTn=38 · small study2018
Einfach gesagt: This proof-of-concept study demonstrates that the metabolomics has a role in evaluating the biological effect of an investigational drug and may be a candidate biomarker as a secondary outcome measure in clinical trials.
Blasco H et al. · PloS one (2018)
To predict SVC from SM C24:1 in group O and SVC from SM OH C22:2 and SM C16:1 in group P+O, we noted a median sensitivity between 67% and 100%, a specificity between 66.7 and 71.4%, a positive predictive value between 66 and 75% and a negative predictive value between 70% and 100% in the test sets.
Changes in metabolomic profiles were closely linked to clinical progression, and correlated with glutamine levels in Group P and amino acids, lipids and spermidine levels in Group O.
Multivariate models accurately predicted disease progression and highlighted the discriminant role of sphingomyelins (SM C22:3, SM C24:1, SM OH C22:2, SM C16:1).
19Reactive hyperemia index (RHI)RCTn=44 · small study2019
Einfach gesagt: This study suggests that consuming Bifal + Arg YG prevents or reduces the risk of atherosclerosis.
Matsumoto M et al. · Nutrients (2019)
The reactive hyperemia index (RHI), the primary outcome, was measured using endo-peripheral arterial tone (EndoPAT).
The change in RHI from week 0 to 12 in the Bifal + Arg YG group was significantly higher than that in the placebo group, indicating that Bifal + Arg YG intake improved endothelial function.
This study suggests that consuming Bifal + Arg YG prevents or reduces the risk of atherosclerosis.
Einfach gesagt: Similarly, no significant effect on the production of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) was induced by...
Manzoni MSJ et al. · Food research international (Ottawa, Ont.) (2017)
Similarly, no significant effect on the production of proinflammatory cytokines tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and anti-inflammatory interleukin-10 (IL-10) was induced by the synbiotic or placebo beverages consumption.
The results herein indicate that both the synbiotic and the placebo beverage consumption have increased polyamines levels, which are often reduced in elderly individuals, without influencing inflammatory responses.
In addition, both placebo and synbiotic beverages seems to contribute by maintaining increased polyamines levels.