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Sqa4.0
Squalane (topisch) – Forschung
Überwiegend Mechanismus / Beobachtung
13 begutachtete Studien
Was die Evidenz sagt
Überwiegend Mechanismus / Beobachtung
Die meisten Studien zu Squalane (topisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.
Die meiste Evidenz stammt aus mittelwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2000–2026 mit einer typischen Studiengröße von 80 Teilnehmenden.
Basierend auf 13 Studien · 3 Meta-Analysen · 2 RCTs · 5,122 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Nach Outcome
Women's health
Überwiegend Mechanismus / Beobachtung6 Studien
Skin healthGlättet die Haut und reduziert den Wasserverlust als leichtes, hautidentisches Emolliens (kosmetisch, kein gesundheitlicher Nutzen) · 1-4 Wochen
Überwiegend Mechanismus / Beobachtung6 Studien
Safety profile
Zu wenige bewertete Studien2 Studien
Cholesterol & lipids
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
Aktives Forschungsgebiet
11 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
200020132026
1Meta-Analysen=2,185 · very large study2024
However, further studies, particularly from the African continent, are warranted to support universal recommendations.
Getaneh FB, Asmare A, Abayneh B, Birre E, Mohammed A, Muche A, Gedefie A, Asmamaw Y, Mengesha Z, Moges N, Birhanu DM, Bitew ZW, Molla A. · BMJ paediatrics open (2024)
A random effects meta-analysis revealed that infants who received massages with emollient oils had a 21% reduced risk of infection (risk ratio=0.79, 95% CI 0.64 to 0.97, I 2 =0.00%).
Subgroup analyses indicated that preterm babies who received topical emollient oil massages with coconut oil, administered twice a day for more than 2 weeks, had a lower likelihood of acquiring an infection compared with their non-massaged counterparts.
Conclusion It is quite evident from this analysis that topical emollient oil application in preterm neonates is most likely effective in preventing infection.
What is new • Low-certainty evidence documented an improvement in skin integrity with the use of topical emollients and a reduction in the incidence of culture-positive neonatal sepsis with topical oil application. • No major adverse effects of topical emollients were observed.
Basu S, Singh P, Priyadarshi M, Chaurasia S, Basu S. · European journal of pediatrics (2026)
A significant decrease in SCS was observed, favoring topical emollients [SMD (95% CI), - 1.11 (- 1.57, - 0.65), I 2 = 85%, 6 studies, n = 2807, high RoB, low CoE].
Conclusion Low-CoE evidence suggested better skin integrity with topical emollients, and a lower incidence of culture-positive neonatal sepsis with topical oil application.
High heterogeneity limits the generalizability of results.
Multidimensional trials integrating biophysical, microbiological, and clinical outcomes are needed to clarify mechanisms and guide targeted clinical application.
Alshehri AF, Majrashi M, Alanazi A, Alshammari K, Alhazzani R, Alzakari M, Bagazi AA, Aldhafyan A, Alqarni F, Almubarak K, Alotaibi BM, Alhammad O, Anab A, AlMusfir S, Aljarbou AZ. · Cureus (2026)
Only one preterm trial directly measured transepidermal water loss (TEWL) and demonstrated a significant reduction with coconut oil.
Overall certainty of evidence ranged from low to moderate.
Topical emollients are associated with improved skin condition and selected clinical outcomes in preterm neonates, despite limited direct evidence of barrier permeability modification.
Conclusion This consensus aims to fill this void by offering clinical recommendations for the care of neonatal skin in hospitalized infants.
Bajaj N, Kumar RK, Inamadar A, Bhandari A, Kumar R, Uttam KG, Mittal J, Suryawanshi P, Wazir S, Hemrajani S, Thakor P. · Frontiers in pediatrics (2025)
Considering topical emollient therapy may significantly reduce mortality and hospital-acquired infections and improve weight gain.
Multisensory stimulation in preterm infants has the potential to enhance feeding, psychomotor development, and visual function.
Providing parents with a booklet that includes skincare regimens for cleansing the baby and protecting the skin barrier is essential for home care of their baby.
By incorporating emollient oils into standard care protocols, healthcare providers can provide additional support to promote optimal growth and development in preterm infants.
Getaneh FB, Mohammed A, Belete AG, Muche A, Ayres A, Asmamaw Y, Mengesha Z, Dimtse A, Misganaw NM, Mihretie DB, Bitew ZW, Mengstu M, Molla A. · PloS one (2024)
The random effects meta-analysis revealed a significant pooled difference in mean weight gain of 52.15 grams (95% CI: 45.96, 58.35), albeit with high heterogeneity (I2 > 93.24%, p 0.000).
A sensitivity analysis was performed, excluding two outlier studies, resulting in a pooled mean weight difference of 78.57grams (95% CI: 52.46, 104.68).
Among the nine studies that reported adverse events, only two mentioned occurrences of rash and accidental slippage in the intervention groups.
Further controlled studies are warranted to confirm efficacy and optimised treatment protocols.
Fernandes B, Mendes AC, Alves SP, Schmidt V, Bizarro AF, Pinto M, Pereira H, Marto J, Lourenço AM. · Veterinary dermatology (2026)
Results Significant reductions were observed in pVAS10 (4.25 ± 1.85 to 3.38 ± 1.79; p = 0.016) and CADESI-04 (24.62 ± 18.48 to 13.43 ± 7.44; p = 0.02) scores.
TEWL (18.63 ± 17.33 to 9.56 ± 10.75; p = 0.049) and pH (6.07 ± 0.97 to 5.41 ± 0.71; p = 0.01) only had significant reductions at the pinnae.
Owner satisfaction was exceptionally high, with 90.47% rating treatment efficacy as 'good to excellent'.
Conclusion The present study concludes that the efficacy of emollient was not inferior to topical luliconazole for maintaining remission in chronic and recurrent dermatophytosis.
Pathania YS, Cds K, Kumar A. · Mycoses (2024)
The recurrence of disease occurred in 20 patients overall, wherein 7 patients (17.5%) in group A and 13 patients (32.5%) in group B at the end of the study (18 weeks); however, the difference between the two groups was not statistically significant (p = .121).
The mean physician global assessment scores of group A and group B at 12 weeks were 4.45 ± 0.74 and 4.15 ± 0.92, 4.43 ± 0.90 and 4.10 ± 0.98 at 14 weeks, 4.0 ± 1.32 and 3.98 ± 1.23 at 16 weeks, 3.85 ± 1.44 and 3.90 ± 1.35 at 18 weeks, respectively.
Conclusion The present study concludes that the efficacy of emollient was not inferior to topical luliconazole for maintaining remission in chronic and recurrent dermatophytosis.
Hui A, Chimhini G, Saungweme M, Kaisi D, Munetsi E, Mujuru HA, Darmstadt GL. · BMC pediatrics (2024)
The primary needs and desires of mothers who have just given birth to preterm infants are having greater agency in their children's care and financial support in purchasing prescribed medications while at the hospital.
Community receptivity to emollient therapy as a cost-effective treatment is high, particularly if mothers are trained to assist with the intervention.
Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments.
Kim SK, Karadeniz F. · Adv Food Nutr Res (2012)
Squalene is a C30H50 hydrocarbon and a major sebum component (~13%); squalane is its saturated (hydrogenated) derivative
Reported skin-hydrating and emollient activities come predominantly from animal and in-vitro work, not dedicated human trials
Frames squalane as a skin-identical lipid for cosmetic/pharmaceutical use rather than a proven therapeutic
Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene; cholesterol; cholesterol esters; and wax esters.
Del Rosso JQ, Kircik L. · J Dermatolog Treat (2024)
Confirms squalene as an endogenous constituent of human sebum, establishing squalane (its stable form) as a skin-identical lipid
Surface sebum lipids contribute to epidermal water retention and barrier/innate-immune function — the basis for squalane's emollient role
Notes some sebum lipids and their oxidation can be comedogenic, contextualizing why inert squalane is preferred cosmetically
The addition of anti-inflammatory ingredients in the moisturizer... containing occlusive (dimethicone), humectants (glycerin, saccharide, butylene glycol, and hyaluronic acid), and emollient (shea butter and squalane) was shown to be significantly better in improving skin hydration in patients with mild to moderate AD.
Prakoeswa CRS, Damayanti, Anggraeni S, Umborowati MA, Sari M, Hendaria MP, Thahir TF. · Dermatol Res Pract (2024)
Double-blind clinical trial in mild-to-moderate atopic dermatitis where squalane was one of the emollient components
Both arms significantly improved skin hydration over 14 days
Squalane was combined with occlusives, humectants, and other emollients — its specific contribution cannot be isolated