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Sqa4.0

Squalane (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

8 begutachtete Studien

Was die Evidenz sagt

Überwiegend Mechanismus / Beobachtung

Die meisten Studien zu Squalane (topisch) sind mechanistisch oder beobachtend statt RCTs, die einen klinischen Effekt messen — betrachte die Ergebnisse als vorläufig.

Die meiste Evidenz stammt aus gemischt-qualitativen randomisierten Studien, veröffentlicht 1994–2024.

Basierend auf 8 Studien · 4 RCTs

Konfidenz

Mittlere Konfidenz

Nach Outcome

Skin healthGlättet die Haut und reduziert den Wasserverlust als leichtes, hautidentisches Emolliens (kosmetisch, kein gesundheitlicher Nutzen) · 1-4 Wochen
Überwiegend Mechanismus / Beobachtung3 Studien
Cholesterol & lipids
Zu wenige bewertete Studien1 Studie
Immune support
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie

Aktives Forschungsgebiet

3 Studien in den letzten 5 Jahren

199420092024

1RCT1994

Miettinen TA, Vanhanen H · Am J Clin Nutr (1994)

Quelle ansehen

2RCT2009

Cho S, Choi CW, Lee DH, Won CH, Kim SM, Lee S · Clin Exp Dermatol (2009)

Quelle ansehen

3RCT1996

Chan P, Tomlinson B, Lee CB, Lee YS · J Clin Pharmacol (1996)

Quelle ansehen

4Übersicht2012

Einfach gesagt: Up to date, anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities of these substances have been reported both in animal models and in vitro environments.

Kim SK, Karadeniz F. · Adv Food Nutr Res (2012)

Squalene is a C30H50 hydrocarbon and a major sebum component (~13%); squalane is its saturated (hydrogenated) derivative
Reported skin-hydrating and emollient activities come predominantly from animal and in-vitro work, not dedicated human trials
Frames squalane as a skin-identical lipid for cosmetic/pharmaceutical use rather than a proven therapeutic

Quelle ansehen

5RCT2024

Einfach gesagt: The addition of anti-inflammatory ingredients in the moisturizer... containing occlusive (dimethicone), humectants (glycerin, saccharide, butylene glycol, and hyaluronic acid), and emollient (shea butter and squalane) was shown to be significantly better in improving skin hydration in patients with mild to moderate AD.

Prakoeswa CRS, Damayanti, Anggraeni S, Umborowati MA, Sari M, Hendaria MP, Thahir TF. · Dermatol Res Pract (2024)

Double-blind clinical trial in mild-to-moderate atopic dermatitis where squalane was one of the emollient components
Both arms significantly improved skin hydration over 14 days
Squalane was combined with occlusives, humectants, and other emollients — its specific contribution cannot be isolated

Quelle ansehen

6Übersicht2024

Einfach gesagt: Within the pilosebaceous unit, androgens drive sebocyte production of sebum, comprising mono-, di-, and triglycerides (the latter converted to fatty acids); squalene; cholesterol; cholesterol esters; and wax esters.

Del Rosso JQ, Kircik L. · J Dermatolog Treat (2024)

Confirms squalene as an endogenous constituent of human sebum, establishing squalane (its stable form) as a skin-identical lipid
Surface sebum lipids contribute to epidermal water retention and barrier/innate-immune function — the basis for squalane's emollient role
Notes some sebum lipids and their oxidation can be comedogenic, contextualizing why inert squalane is preferred cosmetically

Quelle ansehen

7In vitro2021

Einfach gesagt: We have developed oil-based microemulsion formulations composed of a squalane vehicle.

Kitaoka M, Nguyen TC, Goto M. · Int J Cosmet Sci (2021)

Squalane served as the oil vehicle/emollient base of a cosmetic microemulsion — its dominant real-world role as a formulation carrier
On ex-vivo human skin, the squalane-based formulation supported a 25-fold increase in nicotinamide flux driven by the emulsifier, not squalane
Confirms squalane's use as a stable, well-tolerated oil phase; no efficacy endpoint is attributable to squalane

Quelle ansehen

8Tierstudie2000

Einfach gesagt: However, the comedogenicity of reduced Sq-OOH, squalene-hydroxide (Sq-OH) and squalene itself was lower than that of Sq-OOH.

Chiba K, Yoshizawa K, Makino I, Kawakami K, Onoue M. · J Toxicol Sci (2000)

On rabbit-ear skin, squalene monohydroperoxide (the UV-oxidation product) was strongly comedogenic, exceeding known comedogenic ingredients
Unoxidized squalene was far less comedogenic — the comedogenicity risk lies in oxidation, not the parent lipid
Squalane, being fully hydrogenated, cannot form these peroxides — the mechanistic basis for preferring squalane over squalene (animal model)

Quelle ansehen

In der Forschungsbibliothek ansehen

Squalane (topisch) – Forschung

Überwiegend Mechanismus / Beobachtung

Serum concentration and metabolism of cholesterol during rapeseed oil and squalene feeding.

High-dose squalene ingestion increases type I procollagen and decreases ultraviolet-induced DNA damage in human skin in vivo but is associated with transient adverse effects.

Effectiveness and safety of low-dose pravastatin and squalene, alone and in combination, in elderly patients with hypercholesterolemia.

Biological importance and applications of squalene and squalane.

The Role of Moisturizer Containing Anti-inflammatory on Skin Hydration in Mild-Moderate Atopic Dermatitis Patients.

The primary role of sebum in the pathophysiology of acne vulgaris and its therapeutic relevance in acne management.

Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide.

Comedogenicity of squalene monohydroperoxide in the skin after topical application.