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St. John's Wort – Forschung
Gemischte Evidenz
170 begutachtete Studien
Was die Evidenz sagt
Hilft vermutlich
St. John's Wort half in etwa der Hälfte (4/8) der Studien, die einen Effekt gemessen haben — vielversprechend, aber nicht einhellig.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1999–2026 mit einer typischen Studiengröße von 1,049 Teilnehmenden.
Basierend auf 170 Studien · 22 Meta-Analysen · 109 RCTs · 727,708 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen4unklar· 162 weitere ohne bewertete Effektdaten
Nach Outcome
Depression & moodSignificant improvement in depressive symptoms · 4-6 weeks
Gemischte Evidenz124 Studien
Therapeutic & clinical
Gemischte Evidenz66 Studien
Safety profile & drug interactions
Hilft vermutlich36 Studien
Women's healthMay help manage menopausal symptoms like hot flashes and mood changes · 4-8 weeks · Supports healthy estrogen metabolism and hormonal equilibrium · 4-8 weeks
33 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2025
199920122026
1Systematische Übersichtn=1,115 · large study2025
Einfach gesagt: Herbal therapies present a diverse array of options for psoriasis management, but further research is essential to elucidate their safety profile and true effectiveness.
Anheyer M et al. · Complementary therapies in medicine (2025)
Herbal therapies present a diverse array of options for psoriasis management, but further research is essential to elucidate their safety profile and true effectiveness.
Healthcare providers should engage in shared decision-making with patients, considering individual preferences and treatment goals while remaining vigilant in guiding towards evidence-based treatments.
2Response rates in mild depressionMeta-Analysen=1,049 · large study2025
Einfach gesagt: This review demonstrates that certain supplements, such as eicosapentaenoic acids and Rhodiola rosea, are therapeutic options for mild depression.
Urata M et al. · Neuropsychopharmacology reports (2025)
Kein klarer Effekt
← SchlechterKein EffektBesser →
A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88).
Eicosapentaenoic acid and Rhodiola rosea demonstrated significant improvements in depressive symptoms compared to placebo.
Conversely, S-adenosylmethionine did not produce significant improvements relative to placebo.
4Major depression responseMeta-Analysen=5,489 · very large study2016
Einfach gesagt: St. John's wort was significantly superior to placebo and comparable to standard antidepressants for treating major depression with fewer side effects.
Apaydin EA et al. · Systematic Reviews (2016)
Spürbar Nutzen
← SchlechterKein EffektBesser →
St. John's wort was significantly more effective than placebo for major depression (SMD -0.49)
Efficacy was comparable to SSRIs with no significant difference in response rates
Adverse event rates were significantly lower than conventional antidepressants
5HAM-D depression scoresMeta-Analysen=3,808 · very large study2017
Einfach gesagt: For patients with mild-to-moderate depression, St John's wort has comparable efficacy and safety when compared to SSRIs.
Ng QX et al. · Journal of affective disorders (2017)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Likely real
The pooled SMD from baseline HAM-D scores (pooled SMD -0.068, 95% CI -0.127 to 0.021, p<0.001) also support its significant clinical efficacy in ameliorating depressive symptoms.
For patients with mild-to-moderate depression, St John's wort has comparable efficacy and safety when compared to SSRIs.
Follow-up studies carried out over a longer duration should be planned to ascertain its benefits.
Einfach gesagt: This meta-analysis examined the effects of St. John's Wort.
Barrera SD et al. · Scientific reports (2024)
The findings indicated a pain-attenuating effect of herbal extracts such as cannabis, turmeric, capsaicin, licorice, ginger, chamomile, clove, Hypericum perforatum, and Arnica montana.
These findings revindicate that herbal extracts may be valuable alternatives to traditional pain medications and promising source for the development of new active ingredients for pharmaceuticals.
15Warfarin interaction effectsSystematische Übersichtn=149 · medium study2021
Einfach gesagt: While most food, herbs and supplements can be safely taken in moderation, healthcare professionals should be aware of the increased risk of bleeding when taking several food and herbs.
Tan CSS et al. · British journal of clinical pharmacology (2021)
These reports described potentiation with 45 (57.7%) herbs, food or dietary supplements while 23 (29.5%) reported inhibition and 10 (12.8%) reported limited impact on warfarin pharmacokinetics and pharmacodynamics.
While most food, herbs and supplements can be safely taken in moderation, healthcare professionals should be aware of the increased risk of bleeding when taking several food and herbs.
These include Chinese wolfberry, chamomile tea, cannabis, cranberry, chitosan, green tea, Ginkgo biloba, ginger, spinach, St.
17Cognitive function improvement in stroke patientsMeta-Analyse2025
Einfach gesagt: Future longer follow-up, larger samples, and more methodologically rigorous randomized controlled trials are recommended to clearly establish the effects of different dosages on cognitive function and quality of life in stroke patients.
Li J et al. · Phytotherapy research : PTR (2025)
John's Wort extract (SUCRA 71.2%) was the most effective in reducing NIHSS scores, Berberine (SUCRA 84.1%) was most effective in reducing mRS scores, and St.
John's Wort extract (SUCRA 99.1%) showed the highest efficacy in enhancing ADL scores.
Ginsenosides were the most effective in improving Barthel Index (SUCRA 74.7%), MMSE (SUCRA 93%), and MOCA (SUCRA 79.7%) scores.