Tadalafil – Forschung

Analysis of Phosphodiesterase-5 (PDE5) Inhibitors in Modulating Inflammatory Markers in Humans: A Systematic Review and Meta-Analysis

Einfach gesagt: These findings support further investigation of PDE5 in chronic inflammatory conditions.

Cianciarulo C, Nguyen TH, Zacharias A, Standen N, Tucci J, Irving H. · International journal of molecular sciences (2025)

Tadalafil Facilitates the Distal Ureteral Stone Expulsion: A Meta-Analysis.

Bai Y, Yang Y, Wang X, Tang Y, Han P, Wang J · J Endourol (2017)

Efficacy and safety of phosphodiesterase type 5 inhibitors for the treatment of distal ureteral calculi of 5 to 10 mm in size: A systematic review and network meta-analysis.

Li JK, Qiu S, Jin K, Zheng XN, Tu X, Bi SW · Kaohsiung J Med Sci (2019)

Comparative Effectiveness of Tadalafil versus Tamsulosin in Treating Lower Urinary Tract Symptoms Suggestive of Benign Prostate Hyperplasia: A Meta-Analysis of Randomized Controlled Trials.

Guo B, Chen X, Wang M, Hou H, Zhang Z, Liu M · Med Sci Monit (2020)

The Efficacy of Tadalafil Daily vs on Demand in the Treatment of Erectile Dysfunction: A Systematic Review and Meta-analysis.

Bansal UK, Jones C, Fuller TW, Wessel C, Jackman SV · Urology (2018)

Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta-analysis.

Wang Y, Bao Y, Liu J, Duan L, Cui Y · Low Urin Tract Symptoms (2018)

Comparison of Monotherapies and Combination Therapy of Tamsulosin and Tadalafil for Treating Lower Urinary Tract Symptoms Caused by Benign Prostatic Hyperplasia with or without Erectile Dysfunction: A Meta-Analysis.

Liu J, Zhou W, Zhang P, Zhang W, Chang C, Fu G · Urol Int (2024)

Efficacy and Safety of Tadalafil Once-a-Day versus Tadalafil On-Demand in Patients with Erectile Dysfunction: A Systematic Review and Meta-Analyses.

Peng Z, Yang L, Dong Q, Wei Q, Liu L, Yang B · Urol Int (2017)

Chinese herbal medicine combined with tadalafil for erectile dysfunction: a systematic review and meta-analysis.

Wang YL, Geng LG, He CB, Yuan SY · Andrology (2020)

Meta-Analysis of Efficacy and Safety of Tadalafil Plus Tamsulosin Compared with Tadalafil Alone in Treating Men with Benign Prostatic Hyperplasia and Erectile Dysfunction.

Zhou Z, Zheng X, Wu J, Gao Z, Xu Z, Cui Y · Am J Mens Health (2019)

Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.

Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT · Curr Urol Rep (2020)

Phosphodiesterase type 5 inhibitors combined with traditional Chinese medicine for diabetes mellitus-induced erectile dysfunction: A systematic review and meta-analysis

Einfach gesagt: Further high-quality RCTs are needed to validate optimal regimens and long-term outcomes.

Xiang L, Liu A, Tang W, Sun B, Yang Y, Li Y, Chen S, Zhao J, Zhang W, Cai X, Tang X. · Medicine (2025)

A comparative evaluation of on-demand phosphodiesterase-5 inhibitor efficacy in erectile dysfunction treatment: a systematic review and network meta-analysis of double-blind, placebo-controlled, randomized trials

Einfach gesagt: PDE5is are highly effective, with sildenafil showing a significantly greater efficacy compared with the other PDE5is.

Salonia A et al. · The journal of sexual medicine (2026)

Associations between phosphodiesterase type 5 inhibitors and vascular function: a systematic review and meta-analysis on randomized-controlled trials

Einfach gesagt: The title is "Associations between PDE5is and vascular parameters: A systematic review and meta-analysis" ( https://www.crd.york.ac.uk/

Zhang Y, Peng H, Xin S, Mao J, Zhang J, Li H, Luan Y, Liu X, Wang T, Liu J, Zhang H, Song W. · Systematic reviews (2025)

Tamsulosin plus Tadalafil compared with Tamsulosin alone for benign prostate hyperplasia in patients with or without erectile dysfunction: a meta-analysis and meta-regression of randomized controlled trials

Einfach gesagt: However, it was associated with a higher incidence of adverse effects.

Hashmi TM, Zia R, Ashraf H, Siddiqui M, Haider A, Rumampouw V, Khan MA, Ahmed M, Iqbal J. · World journal of urology (2025)

Daily Oral l-Arginine Plus Tadalafil in Diabetic Patients with Erectile Dysfunction: A Double-Blinded, Randomized, Controlled Clinical Trial.

El Taieb M, Hegazy E, Ibrahim A · J Sex Med (2019)

Initial combination therapy with ambrisentan and tadalafil and mortality in patients with pulmonary arterial hypertension: a secondary analysis of the results from the randomised, controlled AMBITION study.

Hoeper MM, McLaughlin VV, Barberá JA, Frost AE, Ghofrani HA, Peacock AJ · Lancet Respir Med (2016)

Effect of mirabegron, tamsulosin, and tadalafil on quality of life in patients with indwelling ureteral (double-J) stents.

Mahmoud Mohammed A, Abdellah Ali Mostafa E, Reyad AM, Ali Abdelhaleem H, Ahmed Mahmoud T · Actas Urol Esp (Engl Ed) (2026)

Erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) combined responders to tadalafil after 12 weeks of treatment.

Roehrborn CG, Egan KB, Miner MM, Ni X, Wong DG, Rosen RC · BJU Int (2016)

Impact of Baseline Total Testosterone Level on Successful Treatment of Sexual Dysfunction in Men Taking Once-Daily Tadalafil 5 mg for Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia: An Integrated Analysis of Three Randomized Controlled Trials.

Mulhall JP, Brock GB, Glina S, Baygani S, Donatucci CF, Maggi M · J Sex Med (2016)