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Tud6.0
TUDCA – Forschung
Hilft wahrscheinlich
52 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
TUDCA scheint in 4 von 4 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1993–2026 mit einer typischen Studiengröße von 24 Teilnehmenden.
Basierend auf 52 Studien · 1 Meta-Analyse · 16 RCTs · 1,238 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
4geholfen· 48 weitere ohne bewertete Effektdaten
Nach Outcome
Liver healthUnterstützt den Gallenfluss und die ER-Stress-Antwort · 4-8 weeks
Hilft wahrscheinlich44 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung18 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung13 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung11 Studien
ALS & motor-neuron disease
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Vision & eye health
Überwiegend Mechanismus / Beobachtung4 Studien
Women's health
Überwiegend Mechanismus / Beobachtung3 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Digestive healthVerbesserter Gallenfluss und verdauungsbezogener Komfort innerhalb von 2-4 Wochen · 2-4 weeks
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 39 Studien mit messbaren Effekten gezogen
Untersuchte Personen
1,238
typische Studie: 24 Personen
Stärkste Designs
17
1 gepoolt, 16 randomisiert
Zeigte Nutzen
100%
4/4 Studien
Wie lange Studien liefen
1–4 Wochen
1
3+ Monate
5
Untersuchte Populationen
Retinal disease patients2
Gastrointestinal cancer patients1
Metabolic diseases1
Motor neuron diseases1
Aktives Forschungsgebiet
30 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
199320092026
1Übersicht2025
Einfach gesagt: Collectively, microbiota-derived metabolites represent promising targets for precision diagnosis and treatment in GI cancer immunotherapy.
Luo W et al. · Frontiers in immunology (2025)
In addition, dietary interventions, probiotics, engineered microbes, and plant-derived nanoparticles offer novel strategies to reshape the microbiota-metabolite-immune axis and improve immunotherapy outcomes.
To pinpoint the sites of metabolite action and mitigate translational risks, we highlight immune-competent organoid co-culture systems.
These platforms enable quantitative assessment of exposure-response thresholds, dissection of context-dependent effects, and in vitro pre-evaluation of the feasibility and safety of metabolite-based immunologic adjuvants combined with PD-1/PD-L1 blockade.
Einfach gesagt: The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation.
Alotaibi G et al. · European journal of pharmacology (2025)
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation.
However, disruptions to ER function, known as ER stress, activate the unfolded protein response (UPR) to restore balance.
Additionally, it discusses emerging therapeutic areas, including soluble epoxide hydrolase (sEH) inhibitors for metabolic disorders and MERCs modulation for neurological diseases.
Einfach gesagt: The evolving understanding of the genetic and pathophysiologic underpinnings of disease offers promise for more effective and clinically meaningful treatments in the future.
Izenberg A · Continuum (Minneapolis, Minn.) (2023)
A coformulation of sodium phenylbutyrate and tauroursodeoxycholic acid has been shown to have a significant benefit on disease progression and survival, leading to approval by regulatory authorities in the United States and Canada.
This article reviews the clinical spectrum of ALS, its variant presentations, and current and emerging disease-modifying therapies.
Einfach gesagt: Therefore, TUDCA has emerged as a potential therapeutic strategy for obesity and comorbidities.
Freitas IN et al. · Frontiers in endocrinology (2023)
In this review, we highlight the effects of TUDCA and receptors TGR5 and FXR on adipose tissue in the setting of obesity.
TUDCA has been demonstrated to limit metabolic disturbs associated to obesity by inhibiting ER stress, inflammation, and apoptosis in adipocytes.
The beneficial effect of TUDCA on perivascular adipose tissue (PVAT) function and adiponectin release may be related to cardiovascular protection in obesity, although more studies are needed to clarify the mechanisms.
5Therapeutic potential of bile acids in neurological disordersSystematische Übersicht2022
Einfach gesagt: Overall, this review confirms the therapeutic potential of UDCA, GUDCA and TUDCA in neurological, neurodegenerative and neuropsychiatric disorders, proposing bile acids as potential alternative the...
Huang F et al. · Brain, behavior, and immunity (2022)
Overall, this review confirms the therapeutic potential of UDCA, GUDCA and TUDCA in neurological, neurodegenerative and neuropsychiatric disorders, proposing bile acids as potential alternative therapeutic approaches for patients suffering from these disorders.
Einfach gesagt: The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Zangerolamo L et al. · Life sciences (2021)
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Our research extends the knowledge of the bile acid TUDCA actions in ND and the mechanisms and pathways involved in its cytoprotective effects on the brain, providing a novel perspective and opportunities for treatment of these diseases.
Einfach gesagt: Research Strategy: Key word searching of PubMed was employed to locate the research papers whose findings are cited in this essay.
McCarty MF · International journal of molecular sciences (2021)
The potential advantages of whole-food plant-based diets, moderation in salt intake, avoidance of phosphate additives, and regular exercise training and sauna sessions are also discussed.
There should be considerable scope for the development of functional foods and supplements which make it more convenient and affordable for patients to consume complementary combinations of the agents discussed here.
Research Strategy: Key word searching of PubMed was employed to locate the research papers whose findings are cited in this essay.
8Systematische Übersichtn=17 · very small study2024
Einfach gesagt: This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment.
Li J et al. · Current neuropharmacology (2024)
This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment.
However, well designed clinical trials are necessary to appraise the efficacy of TUDCA in clinical setting.
9Neuroprotective effects in retinal diseaseÜbersicht2019
Einfach gesagt: As secondary bile acids are generated by the microbiota metabolism, bile acids might be a link between neurodegenerative retinal diseases and microbiota.
Daruich A et al. · Molecular vision (2019)
Ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) have shown antiapoptotic, anti-inflammatory, and antioxidant effects in various models of neurodegenerative diseases.
However, little is known about signaling pathways and molecular mechanisms through which these bile acids act as neuroprotectors, delaying translation to the clinical setting.
We review evidence supporting a potentially therapeutic role for bile acids in retinal disorders, and the mechanisms and pathways involved in the cytoprotective effects of bile acids from the liver and the enterohepatic circulation to the central nervous system and the retina.
10Metabolomics understanding of intrahepatic cholestasis of pregnancySystematische Übersichtn=14 · very small study2022
Einfach gesagt: This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
Yang Z et al. · European journal of medical research (2022)
This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
Xavier JM et al. · The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2016)
Nowadays, mitochondria are constituted by small circular mitochondrial DNA of 16 kb, responsible for the control of several proteins, including polypeptides of the electron transport chain.
Throughout evolution, these organelles acquired the capacity of regulating energy production and metabolism, thus becoming central modulators of cell fate.
12Specific therapy for transthyretin cardiac amyloidosisSystematische Übersicht2020
Einfach gesagt: Novel therapeutic targets including transthyretin gene silencers are currently under investigation.
Marques N et al. · Journal of the American Heart Association (2020)
The one study on AG10 had only a 1-month duration and cardiovascular end points were exploratory and limited to cardiac biomarkers.
Limited evidence from noncomparative single-arm small non-RCTs existed for diflunisal, epigallocatechin-3-gallate (green tea extract), and doxycycline+tauroursodeoxycholic acid/ursodeoxycholic acid.
Conclusions This systematic review of the literature supports the use of tafamidis in wild-type and variant transthyretin-CA.
13Endoplasmic reticulum stress and protein degradation in chronic liver diseaseSystematische Übersicht2020
Einfach gesagt: Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded protein response (UPR).
Xia SW et al. · Pharmacological research (2020)
Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded protein response (UPR).
Accumulated misfolded proteins could activate these arms, and then generate various transcription factors to regulate the expression of UPS-related and autophagy-related genes.
The protein degradation process regulated by UPR has great significance in many chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), viral hepatitis, liver fibrosis, and hepatocellular carcinoma(HCC).
Einfach gesagt: Pancreatic β cells are sensitive to excessive endoplasmic reticulum stress and dysregulated eIF2α phosphorylation, as indicated by transcriptome data, monogenic forms of diabetes and pharmacological studies.
Cnop M et al. · Molecular metabolism (2017)
Pancreatic β cells are sensitive to excessive endoplasmic reticulum stress and dysregulated eIF2α phosphorylation, as indicated by transcriptome data, monogenic forms of diabetes and pharmacological studies.
This should be taken into consideration when devising new therapeutic approaches for diabetes.
15Neuroprotective strategies for retinal diseaseÜbersicht2018
Einfach gesagt: We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.
Pardue MT et al. · Progress in retinal and eye research (2018)
In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies.
Despite the high incidence of retinal diseases and the complexity of mechanisms involved, several promising neuroprotective treatments provide hope to prevent blindness.
We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.
Einfach gesagt: This review explores the findings of recent studies highlighting bile acid-mediated therapies and bile acid-mediated signaling and the roles they play in neurodegenerative and neurological diseases.
Grant SM et al. · International journal of molecular sciences (2020)
Recent studies have shown that bile acid signaling may also have a prevalent role in the central nervous system.
Some bile acids, such as tauroursodeoxycholic acid and ursodeoxycholic acid, have shown neuroprotective potential in experimental animal models and clinical studies of many neurological conditions.
Alterations in bile acid metabolism have been discovered as potential biomarkers for prognosis tools as well as the expression of various bile acid receptors in multiple neurological ailments.
Einfach gesagt: Targeting ERS represents a transformative mechanotherapeutic paradigm for precision hypertension management.
Ma X, Si F, Ma J, Feng C, Wang Y, Wang L, Yu J. · Journal of cellular and molecular medicine (2025)
Notably, conventional antihypertensives-ACE inhibitors and angiotensin receptor blockers (ARBs)-exert ancillary benefits by suppressing ERS beyond their primary RAS blockade.
Preclinical evidence supports the efficacy of these strategies in reversing hypertensive pathophysiology.
Future research must prioritise isoform-selective ERS modulator development, validation in human trials, biomarker discovery, and elucidating ERS roles in therapy-induced hypertension.
Einfach gesagt: In fact, an increase in secondary BAs has been observed in centenarians who have reached old age without serious health issues, which may justify their active role in achieving longevity.
Francini E, Badillo Pazmay GV, Fumarola S, Procopio AD, Olivieri F, Marchegiani F. · International journal of molecular sciences (2025)
In general GM and host organisms interact in many ways.
The presence of Firmicutes and Actinobacteria together with adequate levels of secondary BAs would provide protection and improve the frailty state in the elderly.
In fact, an increase in secondary BAs has been observed in centenarians who have reached old age without serious health issues, which may justify their active role in achieving longevity.
20Pancreatic beta cell resilience to proteotoxic stressÜbersicht2026
Einfach gesagt: This review explores the evidence for IAPP-mediated proteotoxicity in multiple forms of diabetes, the mechanisms of cytotoxicity at different levels of the cell's protein quality control systems, how these small organic compounds may act on these processes including new insights on the role of thioredoxin-interacting protein (TXNIP), and the current evidence supporting each of these compounds in mitigating diabetogenesis.
Valshon K et al. · International journal of molecular sciences (2026)
A small but growing body of research also links IAPP-mediated proteotoxic stress to the pathogenesis of type 1 diabetes and to the functional decline of transplanted islets.
Published in International journal of molecular sciences (2026)