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Tud6.0
TUDCA – Forschung
Hilft wahrscheinlich
51 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
TUDCA scheint in 5 von 5 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2006–2026 mit einer typischen Studiengröße von 24 Teilnehmenden.
Basierend auf 51 Studien · 1 Meta-Analyse · 13 RCTs · 1,272 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
5geholfen· 46 weitere ohne bewertete Effektdaten
Nach Outcome
Liver healthUnterstützt den Gallenfluss und die ER-Stress-Antwort · 4-8 weeks
Hilft wahrscheinlich43 Studien
Neuroprotection & brain aging
Überwiegend Mechanismus / Beobachtung19 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung13 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung12 Studien
ALS & motor-neuron disease
Überwiegend Mechanismus / Beobachtung5 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
Vision & eye health
Überwiegend Mechanismus / Beobachtung4 Studien
Heart & blood pressure
Zu wenige bewertete Studien2 Studien
Women's health
Zu wenige bewertete Studien2 Studien
Digestive healthVerbesserter Gallenfluss und verdauungsbezogener Komfort innerhalb von 2-4 Wochen · 2-4 weeks
Zu wenige bewertete Studien1 Studie
Skin health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 41 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
1,272
typische Studie: 24 Personen
Stärkste Designs
14
1 gepoolt, 13 randomisiert
Zeigte Nutzen
100%
5/5 Studien
Wie lange Studien liefen
1–4 Wochen
1
3+ Monate
5
Untersuchte Populationen
Retinal disease patients2
ALS patients2
Metabolic diseases1
Gastrointestinal cancer patients1
Aktives Forschungsgebiet
32 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200620162026
1Systematische ÜbersichtCited 13×2025
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation.
Alotaibi G et al. · European journal of pharmacology (2025)
The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation.
However, disruptions to ER function, known as ER stress, activate the unfolded protein response (UPR) to restore balance.
Additionally, it discusses emerging therapeutic areas, including soluble epoxide hydrolase (sEH) inhibitors for metabolic disorders and MERCs modulation for neurological diseases.
Collectively, microbiota-derived metabolites represent promising targets for precision diagnosis and treatment in GI cancer immunotherapy.
Luo W et al. · Frontiers in immunology (2025)
In addition, dietary interventions, probiotics, engineered microbes, and plant-derived nanoparticles offer novel strategies to reshape the microbiota-metabolite-immune axis and improve immunotherapy outcomes.
To pinpoint the sites of metabolite action and mitigate translational risks, we highlight immune-competent organoid co-culture systems.
These platforms enable quantitative assessment of exposure-response thresholds, dissection of context-dependent effects, and in vitro pre-evaluation of the feasibility and safety of metabolite-based immunologic adjuvants combined with PD-1/PD-L1 blockade.
The evolving understanding of the genetic and pathophysiologic underpinnings of disease offers promise for more effective and clinically meaningful treatments in the future.
Izenberg A · Continuum (Minneapolis, Minn.) (2023)
A coformulation of sodium phenylbutyrate and tauroursodeoxycholic acid has been shown to have a significant benefit on disease progression and survival, leading to approval by regulatory authorities in the United States and Canada.
This article reviews the clinical spectrum of ALS, its variant presentations, and current and emerging disease-modifying therapies.
Therefore, TUDCA has emerged as a potential therapeutic strategy for obesity and comorbidities.
Freitas IN et al. · Frontiers in endocrinology (2023)
In this review, we highlight the effects of TUDCA and receptors TGR5 and FXR on adipose tissue in the setting of obesity.
TUDCA has been demonstrated to limit metabolic disturbs associated to obesity by inhibiting ER stress, inflammation, and apoptosis in adipocytes.
The beneficial effect of TUDCA on perivascular adipose tissue (PVAT) function and adiponectin release may be related to cardiovascular protection in obesity, although more studies are needed to clarify the mechanisms.
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Zangerolamo L et al. · Life sciences (2021)
The tauroursodeoxycholic acid (TUDCA), one of the acids found in bear bile, is a hydrophilic bile acid and naturally produced in the liver by conjugation of taurine to ursodeoxycholic acid (UDCA).
Our research extends the knowledge of the bile acid TUDCA actions in ND and the mechanisms and pathways involved in its cytoprotective effects on the brain, providing a novel perspective and opportunities for treatment of these diseases.
Research Strategy: Key word searching of PubMed was employed to locate the research papers whose findings are cited in this essay.
McCarty MF · International journal of molecular sciences (2021)
The potential advantages of whole-food plant-based diets, moderation in salt intake, avoidance of phosphate additives, and regular exercise training and sauna sessions are also discussed.
There should be considerable scope for the development of functional foods and supplements which make it more convenient and affordable for patients to consume complementary combinations of the agents discussed here.
Research Strategy: Key word searching of PubMed was employed to locate the research papers whose findings are cited in this essay.
7Systematische ÜbersichtCited 11×n=17 · very small study2024
This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment.
Li J et al. · Current neuropharmacology (2024)
This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment.
However, well designed clinical trials are necessary to appraise the efficacy of TUDCA in clinical setting.
8Therapeutic potential of bile acids in neurological disordersSystematische ÜbersichtCited 92×2022
Overall, this review confirms the therapeutic potential of UDCA, GUDCA and TUDCA in neurological, neurodegenerative and neuropsychiatric disorders, proposing bile acids as potential alternative the...
Huang F et al. · Brain, behavior, and immunity (2022)
Overall, this review confirms the therapeutic potential of UDCA, GUDCA and TUDCA in neurological, neurodegenerative and neuropsychiatric disorders, proposing bile acids as potential alternative therapeutic approaches for patients suffering from these disorders.
This review explores the findings of recent studies highlighting bile acid-mediated therapies and bile acid-mediated signaling and the roles they play in neurodegenerative and neurological diseases.
Grant SM et al. · International journal of molecular sciences (2020)
Recent studies have shown that bile acid signaling may also have a prevalent role in the central nervous system.
Some bile acids, such as tauroursodeoxycholic acid and ursodeoxycholic acid, have shown neuroprotective potential in experimental animal models and clinical studies of many neurological conditions.
Alterations in bile acid metabolism have been discovered as potential biomarkers for prognosis tools as well as the expression of various bile acid receptors in multiple neurological ailments.
11Specific therapy for transthyretin cardiac amyloidosisSystematische ÜbersichtCited 18×2020
Novel therapeutic targets including transthyretin gene silencers are currently under investigation.
Marques N et al. · Journal of the American Heart Association (2020)
The one study on AG10 had only a 1-month duration and cardiovascular end points were exploratory and limited to cardiac biomarkers.
Limited evidence from noncomparative single-arm small non-RCTs existed for diflunisal, epigallocatechin-3-gallate (green tea extract), and doxycycline+tauroursodeoxycholic acid/ursodeoxycholic acid.
Conclusions This systematic review of the literature supports the use of tafamidis in wild-type and variant transthyretin-CA.
12Endoplasmic reticulum stress and protein degradation in chronic liver diseaseSystematische ÜbersichtCited 106×2020
Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded protein response (UPR).
Xia SW et al. · Pharmacological research (2020)
Endoplasmic reticulum (ER) stress is easily observed in chronic liver disease, which often causes accumulation of unfolded or misfolded proteins in the ER, leading to unfolded protein response (UPR).
Accumulated misfolded proteins could activate these arms, and then generate various transcription factors to regulate the expression of UPS-related and autophagy-related genes.
The protein degradation process regulated by UPR has great significance in many chronic liver diseases, including non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), viral hepatitis, liver fibrosis, and hepatocellular carcinoma(HCC).
13Neuroprotective effects in retinal diseaseSystematische ÜbersichtCited 71×2019
As secondary bile acids are generated by the microbiota metabolism, bile acids might be a link between neurodegenerative retinal diseases and microbiota.
Daruich A et al. · Molecular vision (2019)
Ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA) have shown antiapoptotic, anti-inflammatory, and antioxidant effects in various models of neurodegenerative diseases.
However, little is known about signaling pathways and molecular mechanisms through which these bile acids act as neuroprotectors, delaying translation to the clinical setting.
We review evidence supporting a potentially therapeutic role for bile acids in retinal disorders, and the mechanisms and pathways involved in the cytoprotective effects of bile acids from the liver and the enterohepatic circulation to the central nervous system and the retina.
14Neuroprotective strategies for retinal diseaseSystematische ÜbersichtCited 192×2018
We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.
Pardue MT et al. · Progress in retinal and eye research (2018)
In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies.
Despite the high incidence of retinal diseases and the complexity of mechanisms involved, several promising neuroprotective treatments provide hope to prevent blindness.
We discuss attractive candidates here with the goal of furthering retinal research in critical areas to rapidly translate neuroprotective strategies into the clinic.
Pancreatic β cells are sensitive to excessive endoplasmic reticulum stress and dysregulated eIF2α phosphorylation, as indicated by transcriptome data, monogenic forms of diabetes and pharmacological studies.
Cnop M et al. · Molecular metabolism (2017)
Pancreatic β cells are sensitive to excessive endoplasmic reticulum stress and dysregulated eIF2α phosphorylation, as indicated by transcriptome data, monogenic forms of diabetes and pharmacological studies.
This should be taken into consideration when devising new therapeutic approaches for diabetes.
Xavier JM et al. · The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry (2016)
Nowadays, mitochondria are constituted by small circular mitochondrial DNA of 16 kb, responsible for the control of several proteins, including polypeptides of the electron transport chain.
Throughout evolution, these organelles acquired the capacity of regulating energy production and metabolism, thus becoming central modulators of cell fate.
17Pancreatic beta cell resilience to proteotoxic stressSystematische Übersicht2026
This review explores the evidence for IAPP-mediated proteotoxicity in multiple forms of diabetes, the mechanisms of cytotoxicity at different levels of the cell's protein quality control systems, how these small organic compounds may act on these processes including new insights on the role of thioredoxin-interacting protein (TXNIP), and the current evidence supporting each of these compounds in mitigating diabetogenesis.
Valshon K et al. · International journal of molecular sciences (2026)
A small but growing body of research also links IAPP-mediated proteotoxic stress to the pathogenesis of type 1 diabetes and to the functional decline of transplanted islets.
Published in International journal of molecular sciences (2026)
Clinical management is moving beyond empirical fecal microbiota transplantation (FMT), towards precision synthetic microbial consortia (SynComs), neuroprotective BAs like tauroursodeoxycholic acid (TUDCA), and molecular postbiotics to restore the collaborative metabolome.
Németh K, Tóth I, Lányi K, Schilling-Tóth BM, Csorba S, Žura Žaja I, Sterczer Á. · Veterinary sciences (2026)
Recent data have linked these disruptions to skeletal health, feline renal fibrosis, cardiac remodeling in myxomatous mitral valve disease (MMVD), and neuroinflammation in epilepsy and hepatic encephalopathy.
The discovery of microbially conjugated bile acids (MCBAs) and microbial extracellular vesicles (MEVs) reveals highly specific, vesicle-mediated communication pathways impacting systemic health.
Diagnostic protocols should prioritize functional profiling, including the dysbiosis index (DI), serum conjugated BA analysis, and SBA/PBA ratios.
Such advances may help bridge the gap between molecular understanding and therapeutic development for BPD.
Yu H, Guo Y, Wang X, Guo W, Zhang Y. · Frontiers in cell and developmental biology (2026)
Growing evidence indicates that endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are closely involved in the pathogenesis of BPD.
Under hyperoxic conditions, excessive reactive oxygen species promote protein misfolding and accumulation within the endoplasmic reticulum, leading to activation of the three major UPR branches-IRE1, PERK, and ATF6.
Although some agents have demonstrated clinical benefits in reducing BPD-related outcomes, whether these effects are mediated directly through UPR modulation remains uncertain.
20Frailty state in elderlySystematische Übersicht2025
In fact, an increase in secondary BAs has been observed in centenarians who have reached old age without serious health issues, which may justify their active role in achieving longevity.
Francini E, Badillo Pazmay GV, Fumarola S, Procopio AD, Olivieri F, Marchegiani F. · International journal of molecular sciences (2025)
In general GM and host organisms interact in many ways.
The presence of Firmicutes and Actinobacteria together with adequate levels of secondary BAs would provide protection and improve the frailty state in the elderly.
In fact, an increase in secondary BAs has been observed in centenarians who have reached old age without serious health issues, which may justify their active role in achieving longevity.