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Ttl6.0
Turkey Tail – Forschung
Gemischte Evidenz
35 begutachtete Studien
Was die Evidenz sagt
Gemischte Evidenz
Die Studien sind gespalten: Turkey Tail half in 1 von 3 Fällen, der Rest war ergebnislos oder zeigte keinen Nutzen.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 2005–2026 mit einer typischen Studiengröße von 40 Teilnehmenden.
Basierend auf 35 Studien · 3 Meta-Analysen · 8 RCTs · 13,508 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
1geholfen1unklar1nicht geholfen· 32 weitere ohne bewertete Effektdaten
Nach Outcome
Cancer adjunct & oncology
Gemischte Evidenz32 Studien
Immune supportVerbesserte Aktivität und Funktion der Immunzellen · 4-8 Wochen
InflammationPräbiotische Effekte zur Unterstützung des Darmmikrobioms · 4-8 Wochen
Zu wenige bewertete Studien2 Studien
Energy & fatigue
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 31 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
14k
typische Studie: 40 Personen
Stärkste Designs
11
3 gepoolt, 8 randomisiert
Zeigte Nutzen
33%
1/3 Studien
Wie lange Studien liefen
3+ Monate
1
Untersuchte Populationen
Cancer patients9
Breast cancer patients6
Women with HPV infections and cervical dysplasia1
Colorectal cancer patients1
Aktives Forschungsgebiet
15 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2024
200520152026
1HPV and cervical dysplasia treatmentSystematische ÜbersichtCited 1×n=2,324 · very large study2024
The evidence for treating HPV and cervical dysplasia with CAM is of low quality because of lack of standardized, clinically relevant treatment outcomes, lack of standardization of products, and minimal reporting on adverse and long-term effects.
Walsh CJ et al. · Journal of lower genital tract disease (2024)
Adverse events were reported in only 28/56 (50%) of included studies.
The evidence for treating HPV and cervical dysplasia with CAM is of low quality because of lack of standardized, clinically relevant treatment outcomes, lack of standardization of products, and minimal reporting on adverse and long-term effects.
Future large, randomized control trials are needed to further assess efficacy and safety of CAM therapies to address HPV and cervical dysplasia.
2Five-year survivalSystematische ÜbersichtCited 10×n=1,569 · large study2022
Due to the very low certainty of evidence, we were uncertain about the effect of adjunctive Coriolus (in the form of an extract PSK) on adverse events resulting from conventional chemotherapy for colorectal cancer.
Pilkington K et al. · The Cochrane database of systematic reviews (2022)
Kaum spürbar Schaden
← SchlechterKein EffektBesser →
We found low-certainty evidence of a small effect of adjunctive Coriolus on improved survival at five years compared with no adjunctive care (RR 1.08, 95% CI 1.01 to 1.15; 1094 participants; 3 studies; number needed to benefit (NNTB) = 16 (95% Cl 9 to 70).
Due to the very low certainty of evidence, we were uncertain about the effect of adjunctive Coriolus (in the form of an extract PSK) on adverse events resulting from conventional chemotherapy for colorectal cancer.
This includes effects on withdrawal of treatment due to adverse events and on specific adverse outcomes such as neutropenia and nausea.
3Hepatoprotective effects of fungal polysaccharidesSystematische Übersicht2025
Presented evidence indicates that fungal polysaccharides possess considerable potential as multifunctional hepatoprotective agents, highlighting the need for further mechanistic insight and clinical validation.
Szelenberger R et al. · Molecules (Basel, Switzerland) (2025)
Fungal polysaccharides were also shown to improve hepatic function by lowering serum biomarkers of liver injury and ameliorating histopathological damage.
Presented evidence indicates that fungal polysaccharides possess considerable potential as multifunctional hepatoprotective agents, highlighting the need for further mechanistic insight and clinical validation.
This review focuses on the properties of selected medicinal mushrooms and their effects on the human organism and presents current knowledge on the possibilities of their use in the production of functional foods.
Łysakowska P et al. · Molecules (Basel, Switzerland) (2023)
Detailed mechanisms of the effects of medicinal mushrooms on the human organism still require long-term clinical studies to confirm their nutraceutical effects, their safety of use, and their dosage.
Medicinal mushrooms have great potential to be used in the design of innovative functional foods.
There is a need for further research on the possibility of incorporating mushrooms into food products to assess the interactions of their bioactive substances with ingredients in the food matrix.
5Antineoplastic activity against breast cancer cellsSystematische ÜbersichtCited 29×2023
We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
Gariboldi MB et al. · International journal of molecular sciences (2023)
In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action.
In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus.
We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
Shahrajabian MH et al. · Current HIV research (2023)
Terpenes inhibit virus fusion, lectins and flavonoids have an inhibitory impact on viral binding, curcumin and flavonoids inhibit viral DNA integration.
The information provided is gathered from randomized control experiments, review articles, and analytical studies and observations, which are obtained from different literature sources, such as Scopus, Google Scholar, PubMed, and Science Direct from July 2000 to August 2023.
7Anticancer properties of edible and medicinal fungiSystematische ÜbersichtCited 23×2022
In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.
Xu J et al. · Nutrients (2022)
Our review summarizes the research progress on the anticancer properties of edible and medicinal fungi and the underlying molecular mechanism, which may offer a better understanding of this field.
Additionally, few studies have reported the safety and efficacy of extracts from edible and medicinal fungi, which may limit their clinical application.
In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.
10Suppressive action of mushroom extracts on breast cancerSystematische ÜbersichtCited 52×2020
Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
Wong JH et al. · Applied microbiology and biotechnology (2020)
This article reviews mushrooms with anti-breast cancer activity.
Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
11Immune function measures and overall survival in cancer patientsSystematische ÜbersichtCited 1×2020
Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
Neuwirthová J et al. · Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti (2020)
Both extracts from Reishi and Coriolus, if used in combination with standard therapy or as an adjuvant single agent, have shown benefits at immune function measures, tumor-related symptoms and performance status of cancer patients.
Moreover, they have prolonged their disease-free interval and overall survival.
They are well tolerated even in advanced cancer diseases and could be safely used continuously for long periods of time.
12Safety and herb-drug interactions in oncologySystematische ÜbersichtCited 16×2019
It is important to familiarize health care professionals about popular supplements, so patients can be informed to make decisions that maximize benefits and minimize risks.
Hou YN et al. · Cancer journal (Sudbury, Mass.) (2019)
The 10 most searched-for herbs/supplements of 2018 are chaga mushroom, turmeric, ashwagandha, reishi mushroom, graviola, Active Hexose-Correlated Compound, boswellia, dandelion, green tea, and Coriolus versicolor.
Here we discuss their safety, herb-drug interactions, and appropriate uses in the oncology setting, based on literature searches in PubMed.
Over the past 16 years, the evidence for use of these supplements is based mostly on preclinical findings, with few well-designed studies and limited trials conducted in cancer patients.
Wong JH et al. · Current medicinal chemistry (2018)
The purpose of this account is to review the compounds capable of eliciting mitochondria-mediated apoptosis in cancer cells produced by medicinal fungi and plants.
The medicinal fungi discussed encompass Cordyceps, Ganoderma species, Coriolus versicolor and Hypsizygus marmoreus.
The medicinal plants discussed comprise Astragalus complanatus, Dendrobium spp, Dioscorea spp, Glycyrrhiza spp, Panax notoginseng, Panax ginseng, and Momordica charantia.
16Immunomodulatory and antitumor effectsSystematische ÜbersichtCited 11×2015
Because of its unique properties and safety, PSP may become a widely used therapeutic agent in the near future.
Piotrowski J et al. · Postepy higieny i medycyny doswiadczalnej (Online) (2015)
Its anti-tumor effects seemed to be mediated through immunomodulatory regulation.
PSP stimulates cells of the immune system, induces synthesis of cytokines such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α), eicosanoids including prostaglandin E2 (PGE2), histamine, reactive oxygen species and nitrogen mediators.
There is a growing interest in understanding the mechanisms of PSP action.
17Survival in gastric cancerMeta-Analysen=8,009 · very large study2007
The results of this meta-analysis suggest that adjuvant immunochemotherapy with PSK improves the survival of patients after curative gastric cancer resection.
Oba K et al. · Cancer Immunology, Immunotherapy (2007)
The meta-analysis included 8,009 patients from eight randomized controlled trials after central randomization.
The overall hazard ratio for eligible patients was 0.88 (95% confidence interval, 0.79-0.98; P = 0.018) with no significant heterogeneity.
The results of this meta-analysis suggest that adjuvant immunochemotherapy with PSK improves the survival of patients after curative gastric cancer resection.
185-year mortalityMeta-AnalyseCited 43×n=11 · very small study2012
This meta-analysis has provided strong evidence that Yun Zhi would have survival benefit in cancer patients, particularly in carcinoma of breast, gastric and colorectal.
Eliza WL et al. · Recent patents on inflammation & allergy drug discovery (2012)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Of patient randomized to Yun Zhi, there was a 9% absolute reduction in 5-year mortality, resulting in one additional patient alive for every 11 patients treated.
This meta-analysis has provided strong evidence that Yun Zhi would have survival benefit in cancer patients, particularly in carcinoma of breast, gastric and colorectal.
Nevertheless, the findings highlight the need for further evidence from prospective studies of outcome to guide future potential modifications of treatment regimes.
Finally, we conclude by highlighting an herbal formulation PHY906 as a potential adjunct to chemotherapy that might become one of the first US Food and Drug Administration (FDA) approved oral herbal medicines for anti-cancer adjunct treatment.
Sze DM et al. · Hematology. American Society of Hematology. Education Program (2009)
We begin with lessons learned from thalidomide as an effective single drug with multiple mechanisms of action to treat multiple myeloma.
Examples of "supplements" or integrative therapy will be drawn from arsenic trioxide, medicinal mushrooms including Coriolus vesicular and Ganoderma lucidum, followed by the discussion of beta-glucans affecting various immunological important cellular subsets.
Different classes of compounds may enhance distinct immune cell populations that might contribute to a multi-targeted holistic effects on anti-cancer treatment.