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E5.0
Vitamin E – Forschung
Hilft wahrscheinlich
571 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Vitamin E scheint in 19 von 23 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1978–2026 mit einer typischen Studiengröße von 351 Teilnehmenden.
Basierend auf 568 Studien · 86 Meta-Analysen · 412 RCTs · 637,315 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
19geholfen3unklar1nicht geholfen· 545 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureGroße Studien zeigen keinen kardiovaskulären Nutzen; hohe Dosen können das Herzinsuffizienz-Risiko erhöhen · 8-12 weeks
Hilft wahrscheinlich463 Studien
InflammationMetaanalysen zeigen eine moderate Senkung von CRP und einigen Entzündungsmarkern · 8-12 weeks
Hilft wahrscheinlich67 Studien
Therapeutic & clinical
Hilft wahrscheinlich64 Studien
Women's healthNur moderate, verzögerte Linderung von Hitzewallungen; Östrogen ist weitaus wirksamer · 4-8 weeks · Antioxidative Vitamine linderten Dysmenorrhoe in einigen Studien; Vitamin E allein unbestätigt · 1-3 cycles
Überwiegend Mechanismus / Beobachtung37 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung29 Studien
Cholesterol & lipidsGroße Studien zeigen keinen kardiovaskulären Nutzen; hohe Dosen können das Herzinsuffizienz-Risiko erhöhen · 8-12 weeks
Überwiegend Mechanismus / Beobachtung26 Studien
Liver health
Hilft vermutlich23 Studien
Safety profile
Hilft vermutlich16 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung11 Studien
Neuroprotection & brain agingBegrenztes Signal für eine Verlangsamung der Verschlechterung von Spätdyskinesien; kein breiter kognitiver Nutzen · Ongoing
Überwiegend Mechanismus / Beobachtung11 Studien
Men's vitality
Überwiegend Mechanismus / Beobachtung11 Studien
Vision & eye health
Überwiegend Mechanismus / Beobachtung10 Studien
Recovery
Überwiegend Mechanismus / Beobachtung10 Studien
Immune support
Überwiegend Mechanismus / Beobachtung7 Studien
Skin healthAntioxidans; die Evidenz für orale Einnahme zum Hautbild ist gering/schwach · 12 weeks · Plausible antioxidative Rolle, aber wenig Evidenz für orale Supplemente bei der Haut · 4-8 weeks
Überwiegend Mechanismus / Beobachtung5 Studien
Fertility & reproductive
Überwiegend Mechanismus / Beobachtung5 Studien
Joint pain & arthritis
Überwiegend Mechanismus / Beobachtung5 Studien
Endurance & exercise performance
Überwiegend Mechanismus / Beobachtung4 Studien
Bone health
Zu wenige bewertete Studien2 Studien
Depression & mood
Zu wenige bewertete Studien1 Studie
Anxiety & stress
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 77 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
80%
über Studien hinweg
Untersuchte Personen
637k
typische Studie: 351 Personen
Stärkste Designs
498
86 gepoolt, 412 randomisiert
Zeigte Nutzen
83%
19/23 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
4
3+ Monate
2
Untersuchte Populationen
General population9
Alzheimer's disease patients3
Patients with NAFLD2
Women with endometriosis2
Stetige Forschung
152 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
197820022026
1Meta-Analysen=574 · large study2026
Lyons S, Kearney M, Fahey MC, Janjal P, Pandolfo M, Patton P. · The Cochrane database of systematic reviews (2026)
Cardiac abnormalities cause premature death in 60% of people with FRDA.
We calculated the mean difference (MD) or standardised mean difference (SMD) for continuous outcomes, and the risk ratio (RR) for dichotomous outcomes, all with 95% confidence intervals (CIs).
All of the studies enroled both males and females, with the proportion of female participants ranging from 21% to 58%.
2Glycemic control improvementMeta-Analysen=2,171 · very large study2023
Einfach gesagt: In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes.
Asbaghi O et al. · Nutrition journal (2023)
However, in subgroup analyses, we found that vitamin E intake significantly reduced fasting blood glucose in studies with an intervention duration of < 10 weeks.
In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes.
Moreover, short-term interventions with vitamin E have resulted in lower fasting blood glucose in these patients.
4Joint pain, swelling, and stiffness in rheumatoid arthritisMeta-Analysen=39,845 · very large study2023
Einfach gesagt: Vitamin E's ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis.
Kou H et al. · European journal of clinical nutrition (2023)
Vitamin E's ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis.
Vitamin E supplements used on a regular basis can help individuals with RA reduce joint discomfort, edema, and stiffness, as well as enhance their overall quality of life.
5Fasting blood glucose reductionMeta-Analysen=14,223 · very large study2023
Einfach gesagt: Low to very low certainty evidence established chromium supplements as the most effective in reducing fasting blood glucose levels and homeostasis model assessment of insulin resistance (SUCRAs: 90...
Xia J et al. · Pharmacological research (2023)
Low to very low certainty evidence established chromium supplements as the most effective in reducing fasting blood glucose levels and homeostasis model assessment of insulin resistance (SUCRAs: 90.4% and 78.3%, respectively).
Vitamin K supplements ranked best in reducing glycated hemoglobin A1c and fasting insulin levels (SUCRAs: 97.0% and 82.3%, respectively), with moderate to very low certainty evidence.
Vanadium supplements ranked best in lowering total cholesterol levels with very low evidence certainty (SUCRAs:100%).
6Systolic blood pressure reductionMeta-Analysen=2,218 · very large study2024
Einfach gesagt: According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
Qi S et al. · BMJ open (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo.
The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity.
According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
7Major cardiovascular eventsMeta-Analysen=188,209 · very large study2013
Einfach gesagt: Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.
Ye Y, Li J, Yuan Z · PLoS One (2013)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96-1.03).
No effect on myocardial infarction (RR, 0.98; 95%CI, 0.92-1.04), stroke (RR, 0.99; 95%CI, 0.93-1.05), or total death (RR, 1.03; 95%CI, 0.98-1.07).
15 trials reporting data on 188,209 participants were included (vitamin E, beta-carotene, and vitamin C).
8Endometriosis related pelvic pain reductionMeta-Analysen=589 · large study2023
Einfach gesagt: The included studies support the potential role of antioxidant vitamins in the management of endometriosis.
Zheng SH et al. · Reproductive biology and endocrinology : RB&E (2023)
Conversely, supplementation of vitamin D was associated with a reduction in pelvic pain in endometriosis patients, but the difference was not statistically significant compared to the placebo.
Furthermore, the inflammatory markers in peritoneal fluid, including RANTES, interleukin-6, and monocyte chemoattractant protein-1, significantly decreased after antioxidant therapy.
The included studies support the potential role of antioxidant vitamins in the management of endometriosis.
9Aspartate aminotransferase reductionMeta-Analysen=794 · large study2023
Einfach gesagt: Regarding aspartate aminotransferase (AST), patients in the experimental group experienced a reduction in serum levels, though smaller in absolute values [AST MD = -4.65 IU/L, 95% CI (-7.44, -1.86) in studies conducted in Asian populations] and of lower precision in non-Asian studies [MD = -5.60 IU/L, 95% CI (-11.48, 0.28)].
Vogli S et al. · Nutrients (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Three electronic databases (MEDLINE, CENTRAL, and Embase) were reviewed for randomized trials that tested vitamin E supplementation versus placebo or no intervention in patients with NAFLD, published until April 2023.
A total of 794 patients from 12 randomized trials were included in this meta-analysis.
10HDL-c, glycemic indices, hormonal profile in PCOSMeta-Analysen=504 · large study2022
Einfach gesagt: This meta-analysis highlights the potential anti-hyperlipidemic, anti-oxidant, and anti-inflammatory properties of vitamin E supplementation alone or in combination with omega-3 or magnesium on PCOS patients.
Heidari H et al. · Scientific reports (2022)
Vitamin E supplementation or vitamin E in combination with omega-3 or magnesium could significantly reduce serum levels of TG (WMD: -18.27 mg/dL, 95% CI -34.68 to -1.87), LDL-c (-12.84 mg/dL, 95% CI -22.15 to -3.52), and hs-CRP (-0.60 ng/mL, 95% CI -0.77 to -0.44).
No significant effect was found on HDL-c, glycemic indices, hormonal profile, anthropometric measurements, and other biomarkers of inflammation or oxidative stress.
This meta-analysis highlights the potential anti-hyperlipidemic, anti-oxidant, and anti-inflammatory properties of vitamin E supplementation alone or in combination with omega-3 or magnesium on PCOS patients.
Einfach gesagt: Meta-analyses were conducted to compare vitamin E and placebo supplementations to obtain a 95% confidence interval (95%IC).
de Lima KS et al. · International journal of sports medicine (2024)
Meta-analyses were conducted to compare vitamin E and placebo supplementations to obtain a 95% confidence interval (95%IC).
Compared to placebo, vitamin E had no effects on lipid (95%IC= -0.09 to 0.42), protein (-2.44 to 3.11), SOD (-1.05 to 0.23), interleukin-6 (-0.18 to 1.16), creatine kinase (-0.33 to 0.27), muscle soreness (-1.92 to 0.69), and muscle strength (-1.07 to 0.34).
Heterogeneity for the analyses on carbonyls, interleukin-6 (1 h and 3 h), and muscle soreness ranged between 70 to 94%.
13Placental abruption preventionMeta-Analysen=19,023 · very large study2015
Einfach gesagt: The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre-eclampsia, preterm or term PROM or poor fetal growth.
Rumbold A et al. · The Cochrane database of systematic reviews (2015)
Groß Nutzen
← SchlechterKein EffektBesser →
Women supplemented with vitamin E in combination with other supplements compared with placebo were at decreased risk of having a placental abruption (RR 0.64, 95% CI 0.44 to 0.93, seven trials, 14,922 participants, I² = 0%; high quality evidence).
The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre-eclampsia, preterm or term PROM or poor fetal growth.
Further research is required to elucidate the possible role of vitamin E in the prevention of placental abruption.
14Serum alkaline phosphatase reductionMeta-Analysen=351 · medium study2024
Einfach gesagt: Given the very low certainty evidence, we do not know if long-term treatment (18 months to 24 months) with vitamin E administered alone affects all-cause mortality, serious adverse events, quality of life, or non-serious adverse events in people with NAFLD when compared with placebo or no intervention.
Wen H et al. · The Cochrane database of systematic reviews (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Vitamin E may slightly reduce serum alkaline phosphatase (ALP) levels (MD -5.21, 95% CI -9.88 to -0.54; 5 trials, 416 participants; very low certainty evidence), but the evidence is very uncertain.
We found no data on liver-related mortality, liver-related morbidity, or proportion of participants without a decrease in liver enzymes.
Vitamin E likely reduces ALT and AST slightly when compared with placebo, but whether this has any impact on the clinical course in people with NAFLD is unknown.