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E5.0
Vitamin E – Forschung
Hilft wahrscheinlich
141 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Vitamin E scheint in 20 von 24 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1997–2026 mit einer typischen Studiengröße von 351 Teilnehmenden.
Basierend auf 141 Studien · 45 Meta-Analysen · 23 RCTs · 650,719 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
20geholfen3unklar1nicht geholfen· 117 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureGroße Studien zeigen keinen kardiovaskulären Nutzen; hohe Dosen können das Herzinsuffizienz-Risiko erhöhen · 8-12 weeks
Hilft wahrscheinlich99 Studien
InflammationMetaanalysen zeigen eine moderate Senkung von CRP und einigen Entzündungsmarkern · 8-12 weeks
Hilft wahrscheinlich22 Studien
Therapeutic & clinical
Hilft wahrscheinlich20 Studien
Liver health
Hilft vermutlich19 Studien
Women's healthNur moderate, verzögerte Linderung von Hitzewallungen; Östrogen ist weitaus wirksamer · 4-8 weeks · Antioxidative Vitamine linderten Dysmenorrhoe in einigen Studien; Vitamin E allein unbestätigt · 1-3 cycles
Überwiegend Mechanismus / Beobachtung11 Studien
Cognitive function
Überwiegend Mechanismus / Beobachtung9 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung9 Studien
Neuroprotection & brain agingBegrenztes Signal für eine Verlangsamung der Verschlechterung von Spätdyskinesien; kein breiter kognitiver Nutzen · Ongoing
Überwiegend Mechanismus / Beobachtung8 Studien
Cholesterol & lipidsGroße Studien zeigen keinen kardiovaskulären Nutzen; hohe Dosen können das Herzinsuffizienz-Risiko erhöhen · 8-12 weeks
Überwiegend Mechanismus / Beobachtung7 Studien
Safety profile
Hilft vermutlich7 Studien
Fertility & reproductive
Überwiegend Mechanismus / Beobachtung4 Studien
Recovery
Überwiegend Mechanismus / Beobachtung3 Studien
Skin healthAntioxidans; die Evidenz für orale Einnahme zum Hautbild ist gering/schwach · 12 weeks · Plausible antioxidative Rolle, aber wenig Evidenz für orale Supplemente bei der Haut · 4-8 weeks
Zu wenige bewertete Studien2 Studien
Immune support
Zu wenige bewertete Studien2 Studien
Joint pain & arthritis
Zu wenige bewertete Studien2 Studien
Men's vitality
Zu wenige bewertete Studien1 Studie
Endurance & exercise performance
Zu wenige bewertete Studien1 Studie
Bone health
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 78 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
80%
über Studien hinweg
Untersuchte Personen
651k
typische Studie: 351 Personen
Stärkste Designs
68
45 gepoolt, 23 randomisiert
Zeigte Nutzen
83%
20/24 Studien
Wie lange Studien liefen
1–4 Wochen
1
1–3 Monate
4
3+ Monate
2
Untersuchte Populationen
General population8
Adults with type 2 diabetes2
Patients with NAFLD2
Adults2
Aktives Forschungsgebiet
127 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
Lyons S, Kearney M, Fahey MC, Janjal P, Pandolfo M, Patton P. · The Cochrane database of systematic reviews (2026)
Cardiac abnormalities cause premature death in 60% of people with FRDA.
We calculated the mean difference (MD) or standardised mean difference (SMD) for continuous outcomes, and the risk ratio (RR) for dichotomous outcomes, all with 95% confidence intervals (CIs).
All of the studies enroled both males and females, with the proportion of female participants ranging from 21% to 58%.
2Fasting blood glucose reductionMeta-AnalyseCited 31×n=14,223 · very large study2023
Low to very low certainty evidence established chromium supplements as the most effective in reducing fasting blood glucose levels and homeostasis model assessment of insulin resistance (SUCRAs: 90...
Xia J et al. · Pharmacological research (2023)
Low to very low certainty evidence established chromium supplements as the most effective in reducing fasting blood glucose levels and homeostasis model assessment of insulin resistance (SUCRAs: 90.4% and 78.3%, respectively).
Vitamin K supplements ranked best in reducing glycated hemoglobin A1c and fasting insulin levels (SUCRAs: 97.0% and 82.3%, respectively), with moderate to very low certainty evidence.
Vanadium supplements ranked best in lowering total cholesterol levels with very low evidence certainty (SUCRAs:100%).
3Systolic blood pressure reductionMeta-AnalyseCited 12×n=2,218 · very large study2024
According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
Qi S et al. · BMJ open (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Among the five vitamins, only vitamin E was significantly more effective at reducing SBP (mean difference: -14.14 mm Hg, 95% credible intervals: -27.62 to -0.88) than placebo.
The dose of vitamins, geographical region and percentage of males (only SBP) might be sources of heterogeneity.
According to the results, vitamin E might be an effective measure to reduce SBP, but more research is needed to validate this finding.
4Glycemic control improvementMeta-AnalyseCited 42×n=2,171 · very large study2023
In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes.
Asbaghi O et al. · Nutrition journal (2023)
However, in subgroup analyses, we found that vitamin E intake significantly reduced fasting blood glucose in studies with an intervention duration of < 10 weeks.
In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes.
Moreover, short-term interventions with vitamin E have resulted in lower fasting blood glucose in these patients.
6Joint pain, swelling, and stiffness in rheumatoid arthritisMeta-AnalyseCited 16×n=39,845 · very large study2023
Vitamin E's ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis.
Kou H et al. · European journal of clinical nutrition (2023)
Vitamin E's ability to restore the intestinal barrier and improve the gastrointestinal tract may be linked to the prevention and treatment of rheumatoid arthritis.
Vitamin E supplements used on a regular basis can help individuals with RA reduce joint discomfort, edema, and stiffness, as well as enhance their overall quality of life.
7Aspartate aminotransferase reductionMeta-AnalyseCited 39×n=794 · large study2023
Regarding aspartate aminotransferase (AST), patients in the experimental group experienced a reduction in serum levels, though smaller in absolute values [AST MD = -4.65 IU/L, 95% CI (-7.44, -1.86) in studies conducted in Asian populations] and of lower precision in non-Asian studies [MD = -5.60 IU/L, 95% CI (-11.48, 0.28)].
Vogli S et al. · Nutrients (2023)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Three electronic databases (MEDLINE, CENTRAL, and Embase) were reviewed for randomized trials that tested vitamin E supplementation versus placebo or no intervention in patients with NAFLD, published until April 2023.
A total of 794 patients from 12 randomized trials were included in this meta-analysis.
8Endometriosis related pelvic pain reductionMeta-AnalyseCited 40×n=589 · large study2023
The included studies support the potential role of antioxidant vitamins in the management of endometriosis.
Zheng SH et al. · Reproductive biology and endocrinology : RB&E (2023)
Conversely, supplementation of vitamin D was associated with a reduction in pelvic pain in endometriosis patients, but the difference was not statistically significant compared to the placebo.
Furthermore, the inflammatory markers in peritoneal fluid, including RANTES, interleukin-6, and monocyte chemoattractant protein-1, significantly decreased after antioxidant therapy.
The included studies support the potential role of antioxidant vitamins in the management of endometriosis.
9Major cardiovascular eventsMeta-AnalyseCited 136×n=188,209 · very large study2013
Antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.
Ye Y, Li J, Yuan Z · PLoS One (2013)
Kein klarer Effekt
← SchlechterKein EffektBesser →
Antioxidant vitamin supplementation as compared to placebo had no effect on major cardiovascular events (RR, 1.00; 95%CI, 0.96-1.03).
No effect on myocardial infarction (RR, 0.98; 95%CI, 0.92-1.04), stroke (RR, 0.99; 95%CI, 0.93-1.05), or total death (RR, 1.03; 95%CI, 0.98-1.07).
15 trials reporting data on 188,209 participants were included (vitamin E, beta-carotene, and vitamin C).
10PCOS biomarkersMeta-AnalyseCited 20×n=504 · large study2022
This meta-analysis highlights the potential anti-hyperlipidemic, anti-oxidant, and anti-inflammatory properties of vitamin E supplementation alone or in combination with omega-3 or magnesium on PCOS patients.
Heidari H et al. · Scientific reports (2022)
No significant effect was found on HDL-c, glycemic indices, hormonal profile, anthropometric measurements, and other biomarkers of inflammation or oxidative stress.
This meta-analysis highlights the potential anti-hyperlipidemic, anti-oxidant, and anti-inflammatory properties of vitamin E supplementation alone or in combination with omega-3 or magnesium on PCOS patients.
11Placental abruption preventionMeta-AnalyseCited 104×n=19,023 · very large study2015
The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre-eclampsia, preterm or term PROM or poor fetal growth.
Rumbold A et al. · The Cochrane database of systematic reviews (2015)
Groß Nutzen
← SchlechterKein EffektBesser →
Women supplemented with vitamin E in combination with other supplements compared with placebo were at decreased risk of having a placental abruption (RR 0.64, 95% CI 0.44 to 0.93, seven trials, 14,922 participants, I² = 0%; high quality evidence).
The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre-eclampsia, preterm or term PROM or poor fetal growth.
Further research is required to elucidate the possible role of vitamin E in the prevention of placental abruption.
12Serum alkaline phosphatase reductionMeta-AnalyseCited 18×n=351 · medium study2024
Given the very low certainty evidence, we do not know if long-term treatment (18 months to 24 months) with vitamin E administered alone affects all-cause mortality, serious adverse events, quality of life, or non-serious adverse events in people with NAFLD when compared with placebo or no intervention.
Wen H et al. · The Cochrane database of systematic reviews (2024)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Vitamin E may slightly reduce serum alkaline phosphatase (ALP) levels (MD -5.21, 95% CI -9.88 to -0.54; 5 trials, 416 participants; very low certainty evidence), but the evidence is very uncertain.
We found no data on liver-related mortality, liver-related morbidity, or proportion of participants without a decrease in liver enzymes.
Vitamin E likely reduces ALT and AST slightly when compared with placebo, but whether this has any impact on the clinical course in people with NAFLD is unknown.
13Serum CRP levelsMeta-AnalyseCited 79×n=2,102 · very large study2020
Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting.
Asbaghi O et al. · Scientific reports (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (- 0.52, 95% CI - 0.80, - 0.23 mg/L, P < 0.001).
Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6.
In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults.
Meta-analyses were conducted to compare vitamin E and placebo supplementations to obtain a 95% confidence interval (95%IC).
de Lima KS et al. · International journal of sports medicine (2024)
Meta-analyses were conducted to compare vitamin E and placebo supplementations to obtain a 95% confidence interval (95%IC).
Compared to placebo, vitamin E had no effects on lipid (95%IC= -0.09 to 0.42), protein (-2.44 to 3.11), SOD (-1.05 to 0.23), interleukin-6 (-0.18 to 1.16), creatine kinase (-0.33 to 0.27), muscle soreness (-1.92 to 0.69), and muscle strength (-1.07 to 0.34).
Heterogeneity for the analyses on carbonyls, interleukin-6 (1 h and 3 h), and muscle soreness ranged between 70 to 94%.
16Oxidative stress and inflammation biomarkersMeta-AnalyseCited 21×n=491 · medium study2021
Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.
Nguyen TTU et al. · International journal of molecular sciences (2021)
We searched the MEDLINE, EMBASE, Web of Science, and Cochrane Library databases and identified randomized controlled trials of adult patients receiving hemodialysis until 30 August 2021.
A total of 11 trials with 491 randomized patients were included.
Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.
18Total sperm countMeta-AnalyseCited 2×n=459 · medium study2022
Vitamin E could increase the total sperm count and reduce the volume of semen in male infertility patients, and long-term treatment could improve the forward motility rate of sperm.
Wang R et al. · Urology journal (2022)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
The results showed that after vitamin E treatment, semen volume was reduced (95% CI: - 0.55 to - 0.06, SMD = - 0.30, p = 0.015), total sperm count was increased (95% CI: 0.02-0.45, SMD = 0.23, p = 0.035), and the differences were statistically significant.
There were no statistically significant differences in increasing sperm concentration (95% CI: -0.21-0.29, SMD = 0.04, p = 0.769), total sperm motility (95% CI: -0.01-0.42, SMD = 0.20, p = 0.061) or sperm forward motility rate (95% CI: -0.06-0.65, SMD = 0.29, p = 0.106).
Subgroup analysis showed that vitamin E treatment for six months could improve sperm forward motility (95% CI: 0.46-1.14, SMD = 0.80, p <0.001).
19Blood levels of vitamin E in malaria patientsMeta-AnalyseCited 5×n=23 · very small study2023
This study highlights the potential role of vitamin E in the pathogenesis of malaria and suggests that improved vitamin E status might be beneficial for improving disease outcomes.
Kotepui M et al. · Nutrients (2023)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
The majority of the studies (80%) found that vitamin E levels were significantly lower in malaria patients than those who were not infected.
Overall, the results revealed a significant reduction in blood levels of vitamin E in malaria patients when compared with uninfected individuals (p < 0.01, Cohen's d: -2.74, 95% CI: -3.72-(-1.76), I2: 98.69%, 21 studies).
In summary, the present study strongly suggests that vitamin E levels are significantly reduced in malaria patients, with a more pronounced decrease observed in cases of severe malaria.
20Serum vitamin E levelsMeta-AnalyseCited 17×n=141 · medium study2020
Vitamin E supplementation may lead to an improvement in vitamin E levels in people with cystic fibrosis, although evidence we assessed was low quality.
Okebukola PO et al. · The Cochrane database of systematic reviews (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Water-soluble vitamin E Water-soluble vitamin E may improve serum vitamin E levels compared with control at six months, one study (45 participants), mean difference (MD) 19.74 umol/L (95% confidence interval (CI) 13.48 to 26.00) (low-quality evidence).
Similar results were also seen at one month, two studies (32 participants), MD 17.66 umol/L (95% CI 10.59 to 24.74) and at three months, one study (45 participants), MD 11.61 umol/L (95% CI 4.77 to 18.45).
Vitamin E supplementation may lead to an improvement in vitamin E levels in people with cystic fibrosis, although evidence we assessed was low quality.