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Zc6.0
Zinc Carnosine – Forschung
Hilft wahrscheinlich
45 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Zinc Carnosine scheint in 10 von 11 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1998–2026 mit einer typischen Studiengröße von 79 Teilnehmenden.
Basierend auf 45 Studien · 7 Meta-Analysen · 29 RCTs · 275,705 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
10geholfen1unklar· 34 weitere ohne bewertete Effektdaten
Nach Outcome
Wound & ulcer healing
Hilft wahrscheinlich34 Studien
Gut barrier & GIImproved gut lining integrity and reduced stomach discomfort within 4-8 weeks · 4-8 weeks
Hilft wahrscheinlich32 Studien
Therapeutic & clinical
Überwiegend Mechanismus / Beobachtung10 Studien
Safety profile
Überwiegend Mechanismus / Beobachtung5 Studien
InflammationHealed gut lining and reduced inflammation · 4-8 weeks
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 23 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
90%
über Studien hinweg
Untersuchte Personen
276k
typische Studie: 79 Personen
Stärkste Designs
36
7 gepoolt, 29 randomisiert
Zeigte Nutzen
91%
10/11 Studien
Wie lange Studien liefen
1–4 Wochen
2
1–3 Monate
4
3+ Monate
2
Untersuchte Populationen
Patients with pressure ulcers2
Patients with gastric ulcers and H. pylori infection1
patients with NSAID-induced gastropathy1
Patients with zinc deficiency1
Aktives Forschungsgebiet
14 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199820122026
1Meta-Analyse2023
Sureshkumar K, Durairaj M, Srinivasan K, Goh KW, Undela K, Mahalingam VT · Front Biosci (Landmark Ed) (2023)
7Change in serum zinc concentrationMeta-Analyse2020
Einfach gesagt: The dose of 300 mg may be useful among patients with baseline serum zinc concentration of less than 70 µg/dL, and 150 mg for 70 µg/dL or more.
Furihata K et al. · Nutrients (2020)
Spürbar Nutzen
← SchlechterKein EffektBesser →
The dose-combined overall polaprezinc increased the change from baseline by a mean of 9.08 µg/dL (95% confidence interval: 5.46, 12.70; heterogeneity: I2 = 0.61%) compared to the placebo.
A significant dose-response relationship was confirmed (p < 0.001).
Baseline serum zinc concentration was considered an effect modifier in polaprezinc 300 mg.
10Gastric ulcer healing rateRCTn=224 · medium study2022
Einfach gesagt: These findings suggest that the efficacy and safety of polaprezinc were similar to those of rebamipide in the treatment of GU.
Shen W et al. · Medical engineering & physics (2022)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Could be chance
For the primary efficacy endpoint, the effective rates confirmed by gastroscopy, after treatment for the test and control groups were 81.48% and 74.31% (P = 0.1557), respectively.
After 4 and 8 weeks of treatments, both treatment groups had comparable improvements rates in gastrointestinal symptoms (test vs. control: 44.44% vs. 39.45% [P = 0.4559] and 81.48% vs. 77.06% [P = 0.4223]).
These findings suggest that the efficacy and safety of polaprezinc were similar to those of rebamipide in the treatment of GU.
11H. pylori eradication rateRCTn=303 · medium study2017
Einfach gesagt: It appears that standard dose polaprezinc combined with triple therapy can significantly improve the H. pylori eradication rate, without an increase in toxicity.
Tan B et al. · PloS one (2017)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
Likely real
Intention-to-treat (ITT) analysis showed that the rate of H. pylori eradication was significantly higher for Arms A (77.0%) and B (75.9%) compared to Arm C (58.6%) (P < 0.01), whereas there was no difference between Arms A and B (P = 0.90).
Per-protocol (PP) analysis showed that the rate of H. pylori eradication was significantly higher for Arms A (81.1%) and B (83.3%) compared to Arm C (61.4%) (P < 0.01), whereas there was no significant difference between Arms A and B (P = 0.62).
The adverse event rate for Arm B (5.1%) was higher than for Arms A (2.8%) (P = 0.04) and C (1.9%) (P = 0.02).
19Bioequivalence of polaprezinc formulationsCrossovern=24 · very small study2025
Einfach gesagt: The generic and original polaprezinc granules were bioequivalent by pharmacokinetic comparisons in healthy Chinese subjects under fasting and fed conditions.
Xiao M et al. · Clinical and translational science (2025)
The geometric mean ratios (GMR) in primary PK endpoints between the test and reference products with 90% confidence intervals (CI) were calculated.
All 90% CIs of GMRs in Cmax, AUC0-t and AUC0-∞ between the two products were within 80.0%-125.0%.
The generic and original polaprezinc granules were bioequivalent by pharmacokinetic comparisons in healthy Chinese subjects under fasting and fed conditions.
20Taste disorder improvementRCTn=219 · medium study2013
Einfach gesagt: The present study also indicated that examining depressiveness based on the SDS scores and investigating disturbance of each taste quality using the filter-paper disk method are recommended for the diagnosis and determination of the treatment effect of a taste disorder.
Ikeda M et al. · Nihon Jibiinkoka Gakkai kaiho (2013)
Sehr groß Nutzen
← SchlechterKein EffektBesser →
As a result, the zinc-treated arm experienced a statistically significant improvement against the placebo-treated arm in the perceptible threshold scores of the filter-paper disk method 8 weeks after the administration of the investigational drug.
However, the effective ratios based on the initial criteria were 55.6% in the treatment group and 43.2% in the placebo, where no statistical significance was recorded.
Whereas, in approximately 77%, or 168 patients with "normal" SDS scores and with completely impaired taste qualities, the ratio of effective cases reached 60.9% in the zinc-treated group, the ratio of the placebo-treated group reached 39.5%, resulting in a statistical significance.