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Depression & Mood

Supplements researched for supporting emotional resilience, neurotransmitter balance, and psychological well-being. Consult your healthcare provider.

Supplements(5)

SAMecore9/10 evidence

Supports methylation and monoamine synthesis. Caution: consult healthcare provider if bipolar disorder

Dosage: 400-1600mg daily
Timing: Morning on empty stomach, start low
Omega-3core9/10 evidence

Supports brain health and mood (high-EPA)

Dosage: 1000-2000mg EPA daily
Timing: With meals
5-HTPrecommended8.5/10 evidence

Supports serotonin synthesis. Caution: do not combine with SSRIs/SNRIs without medical supervision

Dosage: 50-200mg daily
Timing: Evening, away from protein
Saffronrecommended8/10 evidence

Supports mood via multiple neurotransmitter pathways

Dosage: 30mg daily
Timing: With meals
Vitamin D3recommended9/10 evidence

Supports serotonin production (often deficient)

Dosage: 2000-4000 IU daily
Timing: With a fat-containing meal

Evidence Summary

SAMe has meta-analysis evidence for mood support. High-EPA omega-3 shows consistent benefits in meta-analyses. Saffron has multiple RCTs with effect sizes comparable to some pharmaceuticals.

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This information is for educational purposes only and is not a substitute for professional medical advice. Always consult your healthcare provider before starting any supplement protocol.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Individual results may vary. Supplement protocols are based on published peer-reviewed research.