Nir Barzilai — the metformin minimalist
The TAME-trial metformin researcher’s reported personal regimen is essentially just metformin — taken for his own prediabetes — plus lifestyle. He is publicly skeptical of supplements, would reach for an approved drug first, and explicitly DECLINES vitamin D ("I have the lowest vitamin D in the world and I’m not taking it"). The conservatism is the story; he does not recommend metformin for healthy people outside a trial.
Nir Barzilai is an Israeli geneticist and longevity researcher.
Aimed at (inferred from 2 mapped members)
Evidence makeup
2 of 2 mapped items are gated research compounds — informational only.
Core
- 🧬 Metforminresearch compound
Takes it for his own prediabetes; does not recommend it for healthy people outside the TAME trial.
Emerging 4.0no dose info (for prediabetes)
Situational
- 💧 Empagliflozinresearch compound
Has said he is considering switching from metformin to an SGLT2 inhibitor to see what happens.
Emerging 4.5considering (not confirmed)
Sources: Science (AAAS) profile & interviews