38 peer-reviewed studies · Evidence score: 8.5/10
Chanchlani R et al. • Indian pediatrics (2023)
We found that rizatriptan (good tolerability profile with a dose of 5 mg) and sumatriptan (nasal spray, 10 mg and 20 mg) had higher efficiency as compared to other triptans.
Bertolini F et al. • The Cochrane database of systematic reviews (2022)
This review provides uncertain evidence only regarding the use of hydrocortisone, propranolol, dexamethasone, omega-3 fatty acids, gabapentin, paroxetine, PulmoCare formula, Oxepa formula, or 5-hydroxytryptophan as universal PTSD prevention strategies.
Thorpe J et al. • The Cochrane database of systematic reviews (2018)
There are few, large, high-quality trials comparing combination pharmacotherapy with monotherapy for fibromyalgia, consequently limiting evidence to support or refute the use of combination pharmacotherapy for fibromyalgia.
Sun N et al. • Biogerontology (2025)
The Author(s), under exclusive licence to Springer Nature B.V.
Maffei ME • Nutrients (2020)
5-HTP may improve sleep quality through serotonin-melatonin pathway enhancement, though high-quality RCTs are needed.
Javelle F et al. • Nutrition reviews (2020)
Further trials should overcome these limitations by using placebo-controlled studies that include patients with well-defined depression diagnoses, along with strong characterization of psychological and physiological patient characteristics.
Naglich AC et al. • CNS drugs (2018)
No significant benefit for the use of combinations over single agents was observed.
Haberzettl R et al. • Behavioural brain research (2013)
Considering species differences, we identify a distinct set of behavioral and autonomic responses that are consistently observed following administration of direct and indirect 5-HT agonists.
Carrillo M et al. • Psychopharmacology (2009)
Although 5-HT has an overall inhibitory effect on aggression, the animal's genetic background, drug, treatment time, aggression inducing paradigm, and aggression type are critical variables that influence and modify this effect.
Shaw K et al. • Cochrane Database of Systematic Reviews (2002)
5-HTP and tryptophan appear to be better than placebo for depression.
Bruni O et al. • BMJ clinical evidence (2010)
In this systematic review we present information relating to the effectiveness and safety of the following interventions: antihistamines; behavioural therapy plus antihistamines, plus benzodiazepines, or plus chloral and derivatives; benzodiazepines alone; exercise; extinction and graduated extinction; 5-hydroxytryptophan; light therapy; melatonin; safety/protective interventions for parasomnias; scheduled waking (for parasomnias); sleep hygiene; and sleep restriction.
Trujillo-Martín MM et al. • Movement disorders : official journal of the Movement Disorder Society (2009)
Further investigations with improved trial designs are necessary.(c) 2009 Movement Disorder Society.
Guo S et al. • Gut microbes (2024)
In conclusion, postbiotics have shown promise in relieving chronic diarrhea.
Tian J et al. • Annals of clinical and translational neurology (2024)
NBP treatment might promote the recovery of WAB-AQ in patients with ischemic PSA by increasing levels of monoamine neurotransmitters.
Li S et al. • Nutrients (2025)
However, given the relatively small sample size (n = 30) and short-term (12-week) intervention, these findings should be interpreted cautiously, and further long-term studies with a larger sample size are warranted to confirm these preliminary results.
Truyens M et al. • Gastroenterology (2022)
Despite a significant increase in serum 5-hydroxytryptophan and serotonin levels, oral 5-hydroxytryptophan did not modulate IBD-related fatigue better than placebo. (Trial Registration: Belgian Federal Agency for Medication and Health Products, EudraCT number: 2017-005059-10 and ClinicalTrials.gov: NCT03574948, https://clinicaltrials.gov/ct2/show/NCT03574948.).
Yousefzadeh F et al. • International clinical psychopharmacology (2020)
The results of this study confirm that 5-hydroxytryptophan may be effective as an augmentative agent in treatment of moderate-to-severe OCD.
Qi Y et al. • Molecular & cellular proteomics : MCP (2012)
Additionally, significant changes in the urine levels of 4-hydroxyphenylacetic acid, 5-hydroxyindoleacetic acid, indoleacetic acid, 5-hydroxytryptophan, and 5-hydroxykynurenamine in the CPP group suggest that the development of CPP condition may involve an alteration in symbiotic gut microbial composition.
Sutanto CN et al. • Clinical nutrition (Edinburgh, Scotland) (2024)
5-HTP supplementation can improve certain sleep quality components in older adults and this benefit was more prominently observed in poor sleepers. 5-HTP was also able to improve the gut microbiota composition in poor sleepers.
Evans C et al. • Journal of dietary supplements (2023)
Based on the limited data from this investigation, daily supplementation with 100 mg of 5-HTP may affect body composition.