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Kdh2.5

7-Keto-DHEA Research

Mostly mechanism / observationalModerate safety

3 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most 7-Keto-DHEA studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from mixed-quality randomised trials published 2007–2007 with a typical study size of 215 participants.

Based on 3 studies · 1 RCT · 255 total participants

Confidence

Low

By outcome

Weight managementA small short-term rise in resting metabolic rate in one industry trial; no convincing body-fat or weight outcomes · Unknown
Too few graded studies1 study

Older research base

Newest study from 2007

1Observationaln=215 · medium study2007

This steroid is an intermediate in the biosynthesis of 7-hydroxylated DHEA metabolites and has been shown to possess thermogenic properties.

Kazihnitková H, Zamrazilová L, Hill M, Lapcík O, Pouzar V, Hampl R. · Steroids (2007)

Developed and validated a radioimmunoassay to measure endogenous 7-oxo-DHEA in human serum
Established physiological serum levels in 215 subjects with no overt endocrine disorders
A biochemical/assay paper, not an efficacy trial — characterizes the compound's natural occurrence

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2In Vitro2007

Inhibition of cortisone reduction by 7-oxo-DHEA was of a mixed type with a Ki at 1.13 microM.

Hennebert O, Chalbot S, Alran S, Morfin R. · J Steroid Biochem Mol Biol (2007)

In-vitro study using human skin/tissue homogenates
7-oxo-DHEA interferes with 11beta-HSD1-mediated interconversion of cortisol and cortisone
Purely mechanistic cell/tissue work — no clinical or weight-loss outcomes

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3Crossovern=40 · small study2007

RMR increased significantly by 1.4% during the 7-Keto and 3.4% during the HUM5007 treatment periods compared to placebo.

Zenk JL, Frestedt JL, Kuskowski MA. · J Nutr Biochem (2007)

Randomized double-blind placebo-controlled crossover; 45 enrolled, 40 completed; only 7 days per treatment arm
7-Keto modestly raised resting metabolic rate (~1.4%) versus placebo during calorie restriction
Conducted by an industry-affiliated research center (Minnesota Applied Research Center) — industry-linked

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View in Research Library

7-Keto-DHEA Research

Mostly mechanism / observational

A novel radioimmunoassay of 7-oxo-DHEA and its physiological levels.

Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes.

HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.