1RCTCited 195×2017
Campbell C, McMillan HJ, Mah JK, Tarnopolsky M, Selby K, McClure T · Muscle Nerve (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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8 peer-reviewed studies
What the evidence says
Most ACE-031 studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2001–2026.
Based on 8 studies · 2 RCTs
Confidence
Low confidenceBy outcome
4 studies in the last 5 years
Campbell C, McMillan HJ, Mah JK, Tarnopolsky M, Selby K, McClure T · Muscle Nerve (2017)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Attie KM, Borgstein NG, Yang Y, Condon CH, Wilson DM, Pearsall AE · Muscle Nerve (2013)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: We further discuss the implications of MSTN in muscle hypertrophy, inflammation, and sports performance, highlighting future research directions in precision sports genomics and translational muscle biology.
Chandel S, Uvarajan D, Iyer M, Reddy DH, Siama Z, Giridharan B, Narayanasamy A, M J, Wander A, Vellingiri B. · Comprehensive Physiology (2026)
In plain English: Pathways such as SMAD signaling, in which SMAD moves to the nucleus by making a complex and leads to tissue fibrosis in CKD, STAT3, which drives renal fibroblast activity and the production of ECM, Kidney injury molecule (KIM-1) in the synthesis, deposition of ECM proteins, SERCA2a (sarcoplasmic reticulum Ca 2+ ATPase) in cardiac dysfunction, and NF-κB (Nuclear factor kappa-light-chain-enhancer of activated B cells) in inflammation are involved in Act A signaling, have also been discussed.
Kundra S, Kaur R, Pasricha C, Kumari P, Gurjeet Singh T, Singh R. · International immunopharmacology (2024)
In plain English: Collectively, the current evidence highlights myostatin as a central molecular integrator of mechanical unloading-induced muscle atrophy.
Nieuwenhuijsen DHC, Eggelbusch M, Wüst RCI. · Experimental physiology (2026)
In plain English: By the end of treatment, mean body weight of the ACE-031 group was 16% greater than that of the control group, and wet weights of soleus, plantaris, gastrocnemius, and extensor digitorum longus muscles increased by 33, 44, 46 and 26%, respectively.
Cadena SM, Tomkinson KN, Monnell TE, Spaits MS, Kumar R, Underwood KW, Pearsall RS, Lachey JL. · J Appl Physiol (1985) (2010)
In plain English: Marmosets administered ACE-031 were greater at euthanasia compared to baseline; this was not observed in the vehicle-treated controls.
Cadena SM, Bogdanovich S, Khurana TS, Pullen A, Pearsall RS, Curran E, Faucette R, Lane J, Seehra J, Lachey JL, Mizener AD, Pistilli EE. · PLoS One (2026)
In plain English: Independent transgenic mouse lines for each construct exhibited dramatic increases in muscle mass comparable to those seen in myostatin knockout mice.
Lee SJ, McPherron AC. · Proc Natl Acad Sci U S A (2001)