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Afm3.0
African Mango Research
Mostly mechanism / observational
8 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most African Mango studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2005–2025 with a typical study size of 102 participants.
Based on 8 studies · 5 RCTs · 2,727 total participants
Confidence
High confidence
By outcome
Weight managementSmall single-group trials report modest weight/waist reduction, but a systematic review judged the effect unproven and unreplicated · 4-10 weeks (in the few trials that exist)
Mostly mechanism / observational6 studies
Glucose & metabolicSome trials report lower total/LDL cholesterol and glucose, but from a single research group with poor reporting quality · 4-10 weeks
Too few graded studies2 studies
Steady research
2 studies in the last 5 years
200520152025
1Systematic Reviewn=2,513 · very large study2025
In plain English: Plant-derived natural products significantly impact obesity management, notably in body weight, waist circumference, and lipid profile reduction; however, further high-quality and rigorous studies were needed to establish the clinical efficacy of the plant-derived natural products.
Wiyarta E, Budiman RA, Subroto DRT, Park MN, Mayulu N, Taslim NA, Tjandrawinata RR, Tallei TE, Hardinsyah H, Nurkolis F, Kim B. · Phytotherapy research : PTR (2025)
Green coffee led to the largest reduction in body fat percentage (MD: -2.90%, 95% CI: -4.88 to -0.92) and BMI (MD: -3.08 kg/m 2 , 95% CI: -6.35 to 0.19).
Ephedra was most effective in reducing fasting blood glucose (MD: -4.60 mg/dL, 95% CI: -5.49 to -3.71) and HOMA-IR (MD: -16.20, 95% CI: -18.66 to -13.74).
There were too few direct comparisons between various metabolites; thus, most of the comparisons were indirect comparisons through placebo.
In plain English: Conclusion The review extends our knowledge of the health benefits of IG, where these effects could be attributed to the phytochemicals present.
Hassan YR, El-Shiekh RA, El Hefnawy HM, Michael CG. · Journal of ethnopharmacology (2024)
The defatted extracts are characterized by flavonoid glycosides and ellagic acid derivatives.
Despite their widespread use, IG extracts are still inadequately characterized phytochemically and merit further investigation within the realm of scientific research.
Encouragingly, toxicity studies have demonstrated the relative safety of IG extract at the administered doses.
In plain English: 150 mg twice daily significantly improved body weight, body fat, and metabolic-syndrome parameters versus placebo — but this single-group, industry-linked trial has not been independently replicated.
Ngondi JL, Etoundi BC, Nyangono CB, Mbofung CM, Oben JE · Lipids Health Dis (2009)
102 overweight/obese volunteers randomized to 150 mg IGOB131 twice daily or placebo
Reported significant improvements in body weight, body fat, waist circumference, cholesterol, glucose, CRP, adiponectin and leptin
Conducted by the same Cameroon group that produced most positive Irvingia data; effect sizes are large and unreplicated
In plain English: A Cissus/Irvingia combination outperformed placebo on weight and lipid measures, but Irvingia's independent contribution is confounded by the combination design.
Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS · Lipids Health Dis (2008)
72 overweight/obese participants randomized to placebo, Cissus-only, or Cissus + Irvingia
Both active groups beat placebo on all six measures; the combination was largest
Combination design makes it impossible to isolate Irvingia's effect