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Ag3.5
Agarikon Research
Mostly mechanism / observationalModerate safety
9 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Agarikon studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from mixed-quality studies published 2008–2024.
InflammationEmerging anti-inflammatory properties from polysaccharides · 4-8 weeks
Mostly mechanism / observational3 studies
Safety profile
Too few graded studies1 study
By the numbers
Pulled from 8 studies with measurable effects
Strongest designs
0
0 pooled, 0 randomised
Populations Studied
Cancer models2
Systematic review of F. officinalis studies1
General population for prevention and treatment1
In vitro studies1
Active research area
3 studies in the last 5 years
200820162024
1Therapeutic effects including anti-inflammatory, cytotoxic, and antimicrobial activitySystematic ReviewCited 12×2020
It has been proved that both crude extracts and the compounds isolated from F. officinalis have a wide spectrum of therapeutic effects, including anti-inflammatory, cytotoxic, and antimicrobial effects.
Muszyńska B et al. · Chemistry & biodiversity (2020)
Because of its valuable biological properties and its use in 18th and 19th-century pharmacy, Fomitopsis officinalis used to be mass-collected.
Moreover, the large demand for larch wood and non-wood materials (resin) caused an excessive exploitation of larch forests, which directly contributed to the disappearance of F. officinalis from its natural environment.
The qualities of medicinal preparations obtained from the F. officinalis fruiting bodies are determined by the unique composition of its bioactive compounds, such as: triterpenoids, polysaccharides, organic acids, coumarins and phenolic compounds.
2Antitumor activity through immunity activation and angiogenesis inhibitionObservationalCited 14×2024
The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish,...
Shen Y et al. · International journal of biological macromolecules (2024)
The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish, and surface plasmon resonance (SPR) experiments.
The KD values indicating the association of FOBP50-1 with TLR-4, PD-1, and VEGF, were 4.69 × 10-5, 7.98 × 10-6, 3.04 × 10-6 M, respectively, in the SPR experiments.
All investigations have demonstrated that the homogenous fungal polysaccharide FOBP50-1 has the potential to be turned into a tumor immunotherapy agent.
3Antitumor effect via immune activation and angiogenesis inhibitionObservationalCited 13×2024
The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.
Liu W et al. · International journal of biological macromolecules (2024)
The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.
These effects were mediated by the interactions of FOBP90-1 with TLR-2, TLR-4, PD-L1, and VEGFR-2, as determined through a series of experiments involving cells, transgenic zebrafish, molecular docking simulations, and surface plasmon resonance (SPR).
All the experimental findings have demonstrated that FOBP90-1, a purified fungal polysaccharide, is expected to be utilized as a cancer treatment agent.
4Immune strengthening and antiviral effectsObservationalCited 11×2011
Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
Jakopovich I · International journal of medicinal mushrooms (2011)
If progressive modem medicine were redefined in a more effective and humane way, cancer mycotherapy should be a part of a broad concept of biological prevention and therapy of cancer.
Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
This data provides good basis for an expanded translational study.
Jakopovic B et al. · Molecules (Basel, Switzerland) (2020)
AGARIKON.1 and AGARIKON PLUS exhibited immunostimulatory and antiangiogenic properties in vivo which resulted in significantly increased survival and reduction in tumor volume.
The administration of AGARIKON.1 and AGARIKON PLUS did not show genotoxic effect.
This data provides good basis for an expanded translational study.
8Anti-oxidant and anticancer effects on hepatocellular carcinoma cellsIn VitroCited 12×2022
This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.
Altannavch N et al. · Anti-cancer agents in medicinal chemistry (2022)
This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.
To develop the impact of F. officinalis among natural products to treat/prevent oxidative stress disorders or cancers, further examinations of F. officinalis are needed to develop new natural drugs to treat cancer.
However, this study assessed only one extract, Fo3-chloroformic, which has a significant impact against cancer cell lines.
9Cytotoxic effects on human cancer cell linesIn VitroCited 24×2013
In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.
Durgo K et al. · International journal of medicinal mushrooms (2013)
To determine cytotoxic effects of single and blended mushroom extracts, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red assays were conducted using human small cell lung cancer, lung adenocarcinoma, colon cancer, and brain astrocytoma cancer cells.
These results reveal that these extracts exhibit different cytotoxic effects on tumor cells originating from different tissues.
In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.