Ag3.5

Agarikon Research

9 peer-reviewed studies · Evidence score: 3.5/10

Fomitopsis officinalis: a Species of Arboreal Mushroom with Promising Biological and Medicinal Properties

Muszyńska B et al. • Chemistry & biodiversity (2020)

It has been proved that both crude extracts and the compounds isolated from F. officinalis have a wide spectrum of therapeutic effects, including anti-inflammatory, cytotoxic, and antimicrobial effects.

Because of its valuable biological properties and its use in 18th and 19th-century pharmacy, Fomitopsis officinalis used to be mass-collected.
Moreover, the large demand for larch wood and non-wood materials (resin) caused an excessive exploitation of larch forests, which directly contributed to the disappearance of F. officinalis from its natural environment.
The qualities of medicinal preparations obtained from the F. officinalis fruiting bodies are determined by the unique composition of its bioactive compounds, such as: triterpenoids, polysaccharides, organic acids, coumarins and phenolic compounds.

Systematic Review

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An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis

Shen Y et al. • International journal of biological macromolecules (2024)

The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish,...

The following mechanism examination discovered that FOBP50-1 interacted with TLR-4, PD-1, and VEGF to activate immunity and inhibit angiogenesis according to a series of cell, transgenic zebrafish, and surface plasmon resonance (SPR) experiments.
The KD values indicating the association of FOBP50-1 with TLR-4, PD-1, and VEGF, were 4.69 × 10-5, 7.98 × 10-6, 3.04 × 10-6 M, respectively, in the SPR experiments.
All investigations have demonstrated that the homogenous fungal polysaccharide FOBP50-1 has the potential to be turned into a tumor immunotherapy agent.Copyright © 2024 Elsevier B.V.

Observational

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A fungal polysaccharide from Fomitopsis officinalis as a multi-target molecule to combat cancer

Liu W et al. • International journal of biological macromolecules (2024)

The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.

The following mechanistic analysis discovered that the in vivo antitumor effect was linked to immune activation and angiogenesis inhibition.
These effects were mediated by the interactions of FOBP90-1 with TLR-2, TLR-4, PD-L1, and VEGFR-2, as determined through a series of experiments involving cells, transgenic zebrafish, molecular docking simulations, and surface plasmon resonance (SPR).
All the experimental findings have demonstrated that FOBP90-1, a purified fungal polysaccharide, is expected to be utilized as a cancer treatment agent.Copyright © 2024 Elsevier B.V.

Observational

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New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report

Jakopovich I • International journal of medicinal mushrooms (2011)

Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.

If progressive modem medicine were redefined in a more effective and humane way, cancer mycotherapy should be a part of a broad concept of biological prevention and therapy of cancer.
Also, with a very broad spectrum of action, generally formulated as "to strengthen immunity," MYKOPROTECT. 1 is intended as an important element in the prevention and fighting of serious viral infections, whether they are caused by well-known viruses (hepatitis, HIV, etc.) or newly emerging ones.
Further research warranted to confirm findings

Observational

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Laricifomes officinalis and Fomitopsis officinalis: Chemical Composition and Biological Activities

Girometta C et al. • Mycologia (2019)

Agarikon (Laricifomes officinalis) extracts demonstrate significant antimicrobial and anti-inflammatory properties across multiple in vitro studies.

Agarikon extracts showed broad-spectrum antimicrobial activity against bacteria and viruses
Bioactive compounds include agaricic acid, polysaccharides, and triterpenoids
Anti-inflammatory effects demonstrated in cell culture models

Review

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Antitumor, Immunomodulatory and Antiangiogenic Efficacy of Medicinal Mushroom Extract Mixtures in Advanced Colorectal Cancer Animal Model

Jakopovic B et al. • Molecules (Basel, Switzerland) (2020)

This data provides good basis for an expanded translational study.

AGARIKON.1 and AGARIKON PLUS exhibited immunostimulatory and antiangiogenic properties in vivo which resulted in significantly increased survival and reduction in tumor volume.
The administration of AGARIKON.1 and AGARIKON PLUS did not show genotoxic effect.
This data provides good basis for an expanded translational study.

Animal

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Antiviral activity of Fomitopsis officinalis

Stamets P et al. • Planta Medica (2008)

Agarikon extracts showed potent antiviral activity against multiple viruses.

Broad-spectrum antiviral activity
Active against pox and flu viruses
Multiple active compounds identified

Preclinical

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Anti-oxidant and Anticancerous Effect of Fomitopsis officinalis (Vill. ex Fr. Bond. et Sing) Mushroom on Hepatocellular Carcinoma Cells In Vitro through NF-kB Pathway

Altannavch N et al. • Anti-cancer agents in medicinal chemistry (2022)

This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.

This study reports that Fo3-chloroformic extract is rich in antitumor activity, which was previously not investigated in cancer.
To develop the impact of F. officinalis among natural products to treat/prevent oxidative stress disorders or cancers, further examinations of F. officinalis are needed to develop new natural drugs to treat cancer.
However, this study assessed only one extract, Fo3-chloroformic, which has a significant impact against cancer cell lines.

In Vitro

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Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: contribution of polyphenol and polysaccharide content

Durgo K et al. • International journal of medicinal mushrooms (2013)

In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.

To determine cytotoxic effects of single and blended mushroom extracts, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red assays were conducted using human small cell lung cancer, lung adenocarcinoma, colon cancer, and brain astrocytoma cancer cells.
These results reveal that these extracts exhibit different cytotoxic effects on tumor cells originating from different tissues.
In addition, the comparison of investigated blended mushroom extracts with three well-known commercial mushroom products derived from single mushroom species or single mushroom compounds shows that blended mushroom extracts exhibit significantly stronger cytotoxic effects on human tumor cell lines.

In Vitro

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