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Aged Garlic Extract (Kyolic)
Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
What the evidence says
Aged Garlic Extract appears to help in 13 of 14 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2024 with a typical study size of 65 participants.
Based on 42 studies · 6 meta-analyses · 31 RCTs · 20,272 total participants
Confidence
HighWhat the studies found
By outcome
See full supplement plans that include Aged Garlic Extract.
Aged Garlic Extract has an evidence score of 9/10 — very strong evidence based on 48 indexed studies, including 5 meta-analyses. Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
The commonly studied dose of Aged Garlic Extract is 600-1200mg aged garlic extract. Research points to an estimated optimal dose around 1200mg, with a minimum effective dose near 600mg. Individual response varies — start low and adjust.
The best time to take Aged Garlic Extract is with meals. Take it with food. Aged garlic extract (AGE) is gentler than raw garlic but still best taken with food to minimize any GI discomfort.
Olive Leaf Extract
Likely helpsOleuropein-rich extract with antiviral, antibacterial, and blood pressure-lowering effects — part of the Mediterranean diet's protective profile.
Grape Seed Extract
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Last reviewed May 2026 · evidence from 39 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Aged Garlic Extract (AGE) is produced by aging raw garlic in a controlled process that converts harsh compounds into beneficial ones like S-allyl cysteine. Unlike raw garlic, it's odorless and gentler on the stomach. Strong clinical evidence supports benefits for blood pressure, cholesterol, arterial stiffness, and immune function.
Relaxes blood vessels to lower blood pressure
Protects against oxidative damage
May improve cholesterol profile
How Aged Garlic Extract works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
600-1200mg aged garlic extract
Take with food
| Form | Type |
|---|---|
| 💊Kyolic Aged Garlic Extract (most studied) | Recommended |
| 💊Other aged/fermented garlic extracts | Alternative |
Kyolic is the most clinically studied brand. Aged extracts are odorless unlike raw garlic supplements.
Minimum: 8 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Taking with food improves tolerance. Can be taken any time of day.
You can get aged garlic extract from these foods and drinks. Doses are typical per-serving estimates — actual content varies by brand, brew, cooking, etc.
5 mg per piece
1 clove (~3 g) — yields ~5 mg allicin when crushed + rested 10 min. Aged-garlic extract is a DIFFERENT compound profile (S-allyl-cysteine instead of allicin), but raw garlic is the closest dietary analog.
Meta-analysis shows modest SBP reduction of ~4 mmHg and DBP reduction of ~1.4 mmHg. Effect size is relatively small compared to pharmaceutical interventions. Studies primarily used aged garlic extract forms.
Clinically significant BP lowering
Reduced arterial stiffness
Fewer cold/flu symptoms
Likely safe at food amounts; consult doctor for supplements
May increase bleeding risk
May reduce drug levels
Additive blood pressure lowering
Tip: Take with food
Tip: Aged extract minimizes this
Aged Garlic Extract is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset, garlic breath (mild). Use caution if any of these apply to you: Before surgery (stop 2 weeks prior).
Curcumin
Likely helpsTurmeric's active compound that modulates NF-kB inflammatory pathways — supports mood, joint health, and post-exercise recovery.
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