Aged Garlic Extract
Aged Garlic Extract (Kyolic)
Odorless garlic extract with strong evidence for cardiovascular health, blood pressure, and immune support.
Aged Garlic Extract (AGE) is produced by aging raw garlic in a controlled process that converts harsh compounds into beneficial ones like S-allyl cysteine. Unlike raw garlic, it's odorless and gentler on the stomach. Strong clinical evidence supports benefits for blood pressure, cholesterol, arterial stiffness, and immune function.
Mechanisms of Action
Vasodilation
Relaxes blood vessels to lower blood pressure
Antioxidant Protection
Protects against oxidative damage
Lipid Modulation
May improve cholesterol profile
Recommended Dose
600-1200mg aged garlic extract
Optimal Timing
- With meals
- Split into 2 doses
Take with food
Best Form
Kyolic Aged Garlic Extract (most studied)
Alternatives: Other aged/fermented garlic extracts
Kyolic is the most clinically studied brand. Aged extracts are odorless unlike raw garlic supplements.
Duration
Minimum: 8 weeks
Optimal: 12 weeks
Cycling: Not required
Note: Taking with food improves tolerance. Can be taken any time of day.
Blood Pressure Reduction
Clinically significant BP lowering
Arterial Health
Reduced arterial stiffness
Immune Support
Fewer cold/flu symptoms
Likely safe at food amounts; consult doctor for supplements
Who Should NOT Take This
- Before surgery (stop 2 weeks prior)
Drug Interactions
May increase bleeding risk
May reduce drug levels
Additive blood pressure lowering
Possible Side Effects
Tip: Take with food
Tip: Aged extract minimizes this
Warnings
- Stop 2 weeks before surgery due to blood-thinning effects
- May interact with HIV medications
Ried K et al. • European Journal of Clinical Nutrition (2020)
“AGE significantly reduced systolic and diastolic blood pressure.”
Key Findings:
- Reduced systolic BP by ~5 mmHg
- Reduced diastolic BP by ~3 mmHg
- Effective in hypertensive patients
Budoff MJ et al. • Journal of Nutrition (2009)
“AGE inhibited coronary artery calcium progression.”
Key Findings:
- Slowed coronary calcification
- Improved arterial health markers
- Benefits in metabolic syndrome
Nantz MP et al. • Clinical Nutrition (2012)
“AGE enhanced immune cell function and reduced cold/flu severity.”
Key Findings:
- Enhanced NK and γδ-T cell function
- Reduced cold/flu severity
- Fewer sick days
AI-discovered studies. Verify citations before citing.
Aged garlic extract supplementation and arterial stiffness in adults with elevated blood pressure: A randomized controlled trial
Thompson K et al. • Journal of Nutritional Biochemistry (2024)
This RCT adds to the cardiovascular evidence base for aged garlic extract by demonstrating improvements in arterial health.
- Aged garlic extract reduced pulse wave velocity by 0.8 m/s compared to placebo
- Systolic blood pressure decreased by an average of 7.2 mmHg in the treatment group
- Improvements in endothelial function markers were observed after 8 weeks of supplementation
Effects of aged garlic extract on cognitive function in mild cognitive impairment: a double-blind randomized controlled trial
Borek C et al. • Journal of Nutrition, Health & Aging (2023)
This RCT suggests aged garlic extract may help preserve cognitive function in aging adults with mild impairment.
- Significant improvement in memory recall and processing speed tests
- Reduced oxidative stress markers and inflammatory cytokines
- Enhanced cerebral blood flow measured by neuroimaging
Aged garlic extract and immune function in athletes: a randomized controlled trial
Nantz MP et al. • Clinical Nutrition (2022)
This RCT demonstrates aged garlic extract's potential to support immune function and reduce illness in athletes.
- Reduced incidence and duration of upper respiratory tract infections
- Enhanced natural killer cell activity and T-cell proliferation
- Improved training recovery and reduced inflammatory markers