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Agmatine Sulfate
Arginine metabolite that modulates NMDA receptors and nitric oxide — supports mood, pain management, and neuroprotection.
What the evidence says
Agmatine appears to help in 3 of 3 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality randomised trials published 2005–2025 with a typical study size of 51 participants.
Based on 30 studies · 2 RCTs · 123 total participants
Confidence
LowWhat the studies found
By outcome
Agmatine has an evidence score of 7/10 — strong evidence based on 30 indexed studies, including 1 meta-analysis. Arginine metabolite that modulates NMDA receptors and nitric oxide — supports mood, pain management, and neuroprotection.
The commonly studied dose of Agmatine is 500-2500mg daily. Research points to an estimated optimal dose around 2000mg, with a minimum effective dose near 500mg. Individual response varies — start low and adjust.
The best time to take Agmatine is between meals. It can be taken on an empty stomach. Agmatine is a decarboxylated arginine derivative.
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Last reviewed May 2026 · evidence from 40 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Agmatine is a metabolite of the amino acid arginine, produced by removing the carboxylic acid group. It functions as a neurotransmitter and neuromodulator with diverse effects including NMDA receptor antagonism, imidazoline receptor agonism, and nitric oxide synthase modulation. It has shown promise for mood support, neuroprotection, pain management, and may help regulate tolerance to stimulants and opioids.
Blocks NMDA receptors
Activates imidazoline receptors
Regulates NO synthase
How Agmatine works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
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500-2500mg daily
Loading: Not required
Can be taken without food
| Form | Type |
|---|---|
| 💊Agmatine Sulfate | Recommended |
Agmatine sulfate is the standard supplemental form. Available as powder or capsules.
Minimum: 4 weeks
Optimal: 12 weeks
Cycling: 4-6 weeks on, 1-2 weeks off; or as needed for workout support
Note: Better absorbed on empty stomach. For workout purposes, take 30-60 minutes before training.
Based on single pilot study (n=11) showing 46% pain reduction. Very limited evidence with small sample size. GI discomfort may occur at higher doses. Individual variation noted in study.
Antidepressant-like effects
May reduce neuropathic pain
May prevent tolerance to certain substances
Improved vascularity during exercise
Promising adjunct; consult with doctor before use
May enhance hypotensive effects
May affect insulin sensitivity; monitor glucose
Tip: Take with food if needed
Tip: Start with lower dose
Agmatine is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are GI discomfort, low blood pressure. Use caution if any of these apply to you: Known allergy or hypersensitivity to Agmatine or related compounds.
Acetyl-L-Carnitine
Likely helpsAcetylated carnitine that crosses the blood-brain barrier to fuel mitochondrial energy and donate acetyl groups for acetylcholine synthesis.