1Meta-Analysis1997
Mangano DT · JAMA (1997)
No plain-language summary recorded for this citation — open the paper to read its abstract.
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11 peer-reviewed studies
What the evidence says
Most AICAR (Acadesine) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1994–2019.
Based on 11 studies · 1 meta-analysis · 6 RCTs
Confidence
Moderate confidenceBy outcome
Newest study from 2019 · Latest meta-analysis: 1997
Mangano DT · JAMA (1997)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Newman MF, Ferguson TB, White JA, Ambrosio G, Koglin J, Nussmeier NA · JAMA (2012)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Mangano DT, Miao Y, Tudor IC, Dietzel C · J Am Coll Cardiol (2006)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Menasché P, Jamieson WR, Flameng W, Davies MK · J Thorac Cardiovasc Surg (1995)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Holdright DR, Sparrow JL, Wright CL, Steiner J, Fox KM · Cardiovasc Drugs Ther (1994)
No plain-language summary recorded for this citation — open the paper to read its abstract.
· Anesthesiology (1995)
No plain-language summary recorded for this citation — open the paper to read its abstract.
Leung JM, Stanley T, Mathew J, Curling P, Barash P, Salmenpera M · Anesth Analg (1994)
No plain-language summary recorded for this citation — open the paper to read its abstract.
In plain English: Such so-called exercise or caloric restriction 'mimetics' have so far mostly been described in pre-clinical, experimental settings with limited translation into humans.
Handschin C · Pharmacological Research (2016)
In plain English: The most efficacious compounds that induce muscle hypertrophy or endurance are hampered by severe side effects and are classified as doping.
Weihrauch M, Handschin C · Biochemical Pharmacology (2018)
In plain English: Even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%.
Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, et al. · Cell (2008)
In plain English: Stimuli-inducible GLUT4 release relies on Tbc1d1-evoking proximal stimuli, such as AICAR and intracellular Ca2+.
Hatakeyama H, Morino T, Ishii T, Kanzaki M · The Journal of Biological Chemistry (2019)