Cao YX, Li S, Liu HH, Li JJ · BMJ Open (2018)
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214 peer-reviewed studies
What the evidence says
Most Alirocumab (Praluent) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2012–2026 with a typical study size of 206 participants.
Based on 214 studies · 62 meta-analyses · 130 RCTs · 206 total participants
Confidence
High confidenceBy outcome
93 studies in the last 5 years · Latest meta-analysis: 2026
Cao YX, Li S, Liu HH, Li JJ · BMJ Open (2018)
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Ghasempour G, Zamani-Garmsiri F, Shaikhnia F, Soleimani AA, Hosseini Fard SR, Leila J · Curr Med Chem (2024)
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Harvey PD, Sabbagh MN, Harrison JE, Ginsberg HN, Chapman MJ, Manvelian G · Eur Heart J (2018)
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Rivera FB, Cha SW, Magalong JV, Bantayan NRB, Cruz LLA, Arias-Aguirre E · Curr Med Res Opin (2024)
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Cao YX, Liu HH, Dong QT, Li S, Li JJ · Diabetes Obes Metab (2018)
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Zhu Y, Shen X, Jiang Q, Wang Z, Wang Z, Dong X · Herz (2019)
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Pamporis K, Karakasis P, Simantiris S, Sagris M, Bougioukas KI, Fragakis N · Clin Investig Arterioscler (2024)
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Sahebkar A, Di Giosia P, Stamerra CA, Grassi D, Pedone C, Ferretti G · Br J Clin Pharmacol (2016)
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Ariyanti D, Rayyan MIR, Shabri HA, Nurwahyudi N, Husniatama MD, Erisadana RN · Curr Med Res Opin (2026)
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Raone L, Gritti V, Mandurino-Mirizzi A, Sparasci FM, Scotti V, Currao A · Am J Cardiovasc Drugs (2026)
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Zhou Z, Zhang W, Burgner D, Tonkin A, Zhu C, Sun C · Am J Med (2023)
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Geng Q, Li X, Sun Q, Wang Z · Cardiol J (2022)
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Kao G, Chen C, Zhang Y, Xu Y, Xu G · BMC Cardiovasc Disord (2025)
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Shin KH, Choi HD · Int J Clin Pharmacol Ther (2024)
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Bajaj NS, Patel N, Kalra R, Ahmad A, Venkatraman A, Arora G · Eur Heart J Qual Care Clin Outcomes (2018)
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Deng CJ, Yan J, Zheng YY, Wu TT, Pan Y, Hou XG · BMJ Open (2023)
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Casula M, Olmastroni E, Boccalari MT, Tragni E, Pirillo A, Catapano AL · Pharmacol Res (2019)
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Williams DM, Finan C, Schmidt AF, Burgess S, Hingorani AD · Ann Neurol (2020)
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Chen Q, Wu G, Li C, Qin X, Liu R, Zhang M · Am J Cardiovasc Drugs (2020)
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Movahedan M, Ellis UM, Barry AR · Am J Cardiovasc Drugs (2025)
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