Ali S, Wahbi W · Oral Dis (2017)
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116 peer-reviewed studies
What the evidence says
Most Aloe Vera studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1991–2026 with a typical study size of 3,582 participants.
Based on 116 studies · 10 meta-analyses · 79 RCTs · 3,582 total participants
Confidence
High confidenceBy outcome
7 more outcomes with fewer studies not shown.
34 studies in the last 5 years · Latest meta-analysis: 2022
Ali S, Wahbi W · Oral Dis (2017)
Heydarirad G, Ahadi B, Molavi Vardanjani H, Cramer H, Mirzaei HR, Pasalar M · J Altern Complement Med (2021)
Zhang Y, Liu W, Liu D, Zhao T, Tian H · Nutrients (2016)
Gok Metin Z, Helvaci A, Gulbahar Eren M · J Adv Nurs (2021)
Dick WR, Fletcher EA, Shah SA · J Altern Complement Med (2016)
Zheng GH, Yang L, Chen HY, Chu JF, Mei L · Cochrane Database Syst Rev (2014)
Al-Maweri SA, Ashraf S, Lingam AS, Alqutaibi A, Abdulrab S, Alaizari N · J Oral Pathol Med (2019)
Suksomboon N, Poolsup N, Punthanitisarn S · J Clin Pharm Ther (2016)
Zou H, Liu Z, Wang Z, Fang J · Oral Health Prev Dent (2022)
Sharma S, Alfonso AR, Gordon AJ, Kwong J, Lin LJ, Chiu ES · Adv Skin Wound Care (2022)
Baldi A, Sommella E, Campiglia P, Daglia M · Regul Toxicol Pharmacol (2021)
Nazeam JA, Gad HA, El-Hefnawy HM, Singab AB · J Chromatogr B Analyt Technol Biomed Life Sci (2017)
Vogler BK, Ernst E · Br J Gen Pract (1999)
Dhingra K · Oral Dis (2014)
In plain English: Despite generally favorable results, the studies varied considerably in design and quality; nonetheless, herbal extracts represent a prominent category of natural interventions in AD and MCI, underscoring the need for further large-scale, high-quality clinical trials to confirm their therapeutic potential.
Bayo Jimenez MT, Rivas-García L, Sánchez-González C, Grosso G, Lipari V, Vera-Ramírez L, Battino M, Giampieri F, Quiles JL, Forbes-Hernández TY. · International journal of molecular sciences (2025)
Ulbricht C, Armstrong J, Basch E, Basch S, Bent S, Dacey C · J Herb Pharmacother (2007)
Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C · Burns (2007)
Richardson J, Smith JE, McIntyre M, Thomas R, Pilkington K · Clin Oncol (R Coll Radiol) (2005)
Zago LR, Prado K, Benedito VL, Pereira MM · Braz J Biol (2021)
Dat AD, Poon F, Pham KB, Doust J · Cochrane Database Syst Rev (2012)