38 peer-reviewed studies · Evidence score: 9/10
Kohandel Gargari O et al. • JAMA network open (2024)
In this network meta-analysis of randomized clinical trials, topiramate and pregabalin were associated with reduction in headache frequency and intensity.
Hsieh RY et al. • Nutrients (2023)
The use of ALA to prevent neurological symptoms should be further researched.
Sharifi-Zahabi E et al. • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (2024)
ALA supplementation had no statistically significant effect on iron-related parameters.
Vajdi M et al. • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (2023)
In summary, ALA supplementation improves inflammatory markers without any evidence of non-linear association to dose or duration of the trial.
Hajizadeh-Sharafabad F et al. • Critical reviews in food science and nutrition (2022)
In conclusion, these results suggest improvement of endothelial function, but not endothelium-independent vasodilation as a potential mechanism by which ALA attenuates cardiovascular diseases.
An P et al. • Journal of the American College of Cardiology (2022)
Supplementation of some but not all micronutrients may benefit cardiometabolic health.
Namazi N et al. • Clinical Nutrition ESPEN (2018)
ALA supplementation resulted in significant reductions in body weight and BMI compared to placebo.
Talandashti MK et al. • Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2025)
The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis.
Michaelsen MP et al. • Nutrients (2025)
This study found no convincing evidence of an effect of any dietary supplements on male infertility.
Rezaei H et al. • Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (2025)
These findings revealed that ALA supplementation slightly but significantly reduced blood levels of high-sensitivity C-reactive protein, total cholestrol, and low-density lipoprotein cholesterol, but did not affect IL-6, malondialdehyde, high-density lipoprotein cholesterol, weight, body mass index, iron, and hemoglobin in patients with CKD.
Rossetti A et al. • Clinical oral investigations (2025)
While topical clonazepam, alpha-lipoic acid, and low-level laser therapy (LLLT) emerged as potentially effective options in several RCTs, the overall strength of evidence is limited.
Frediani JK et al. • Pain practice : the official journal of World Institute of Pain (2024)
Based on the review, we cannot recommend any supplement use for the management of CIPN, although further research into N-acetyl-cysteine, l-carnosine, crocin, and magnesium is warranted.
Wang Q et al. • Pharmaceutical biology (2024)
This network meta-analysis confirms the efficacy and safety of 37 CPMs combined with Mec or αLA for treating DPN.
Ran GL et al. • Journal of diabetes and its complications (2024)
For diabetic peripheral neuropathy, the triple-combination therapy may be more effective than monotherapy or dual therapy.
Kishi T et al. • Journal of clinical psychopharmacology (2023)
This meta-analysis examined the effects of Alpha Lipoic Acid.
Alvarenga-Brant R et al. • Journal of dental research (2023)
More randomized controlled trials comparing treatments against placebo are encouraged to confirm the evidence and test possible alternative treatments (PROSPERO CRD42021255039).
Orellana-Donoso M et al. • Medicine (2023)
In comparison to the use of a placebo, the findings suggest that ALA does not exhibit significant differences in terms of pain reduction and different functional scales.
Mousavi SM et al. • Nutrition (Burbank, Los Angeles County, Calif.) (2019)
Effect sizes were combined with fixed- or random-effects analysis, where appropriate.
Prado MB Jr et al. • Canadian journal of diabetes (2024)
ALA and GLA appear to be safe and efficacious biofactors for improvement of DN symptoms.
Tan HL et al. • Cephalalgia : an international journal of headache (2022)
A more significant volume in terms of sample size, multi-centres, and multi-arm comparison of therapeutic agents with placebo and longitudinal follow-up studies is recommended to establish a standardised burning mouth syndrome treatment protocol.