1Meta-Analysis2015
Andrade C, Kisely S, Monteiro I, Rao S · J Psychiatr Res (2015)
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77 peer-reviewed studies
What the evidence says
Most Armodafinil (Nuvigil) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2006–2024.
Based on 77 studies · 20 meta-analyses · 44 RCTs
Confidence
High confidenceBy outcome
12 studies in the last 5 years · Latest meta-analysis: 2024
Andrade C, Kisely S, Monteiro I, Rao S · J Psychiatr Res (2015)
Sukhal S, Khalid M, Tulaimat A · J Clin Sleep Med (2015)
Kuan YC, Wu D, Huang KW, Chi NF, Hu CJ, Chung CC · Clin Ther (2016)
Tomlinson D, Robinson PD, Oberoi S, Cataudella D, Culos-Reed N, Davis H · Curr Oncol (2018)
Pitre T, Mah J, Roberts S, Desai K, Gu Y, Ryan C · Ann Intern Med (2023)
Darwish M, Kirby M, Robertson P, Hellriegel ET · Clin Pharmacokinet (2008)
Wang Y, Zhang W, Ye H, Xiao Y · Sleep Med Rev (2024)
Sabe M, Kirschner M, Kaiser S · J Clin Psychopharmacol (2019)
Avellar AB, Carvalho LB, Prado GF, Prado LB · Sleep Med Rev (2016)
Chapman JL, Vakulin A, Hedner J, Yee BJ, Marshall NS · Eur Respir J (2016)
Nunez NA, Singh B, Romo-Nava F, Joseph B, Veldic M, Cuellar-Barboza A · Bipolar Disord (2020)
Maski K, Trotti LM, Kotagal S, Robert Auger R, Swick TJ, Rowley JA · J Clin Sleep Med (2021)
Osugo M, Whitehurst T, Shatalina E, Townsend L, O'Brien O, Mak TLA · Neurosci Biobehav Rev (2022)
McIntyre RS, Lee Y, Zhou AJ, Rosenblat JD, Peters EM, Lam RW · J Clin Psychopharmacol (2017)
Keam S, Walker MC · Curr Opin Neurol (2007)
Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH · J Clin Psychiatry (2013)
Ronnebaum S, Bron M, Patel D, Menno D, Bujanover S, Kratochvil D · J Clin Sleep Med (2021)
Szmulewicz AG, Angriman F, Samamé C, Ferraris A, Vigo D, Strejilevich SA · Acta Psychiatr Scand (2017)
Neshat SS, Heidari A, Henriquez-Beltran M, Patel K, Colaco B, Arunthari V · Sleep Med Rev (2024)
Mücke M, Cuhls H, Peuckmann-Post V, Minton O, Stone P, Radbruch L · Cochrane Database Syst Rev (2015)