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Asa3.0

Aspirin (low-dose) Research

Mostly mechanism / observational

1,001 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Aspirin (low-dose) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 2009–2026 with a typical study size of 760 participants.

Based on 999 studies · 309 meta-analyses · 649 RCTs · 179,343 total participants

Confidence

High confidence

By outcome

Cardiovascular preventionGenuinely reduces recurrent cardiovascular events in people with established cardiovascular disease (secondary prevention; no benefit shown in healthy older adults) · Ongoing daily use
Mostly mechanism / observational341 studies
Safety profile
Mostly mechanism / observational73 studies
Healthy aging & mortality
Mostly mechanism / observational10 studies

Active research area

530 studies in the last 5 years · Latest meta-analysis: 2026

200920172026

1Meta-Analysis2025

Petrelli F, Ghidini A, Antista M, Meli N, Dottorini L, Rossitto M · Public Health (2025)

Aspirin (low-dose) Research

Mostly mechanism / observational

Effect of aspirin use on cancer incidence and mortality: An updated systematic review and meta-analysis.

Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis.

Aspirin Use Is Associated with a Reduced Incidence of Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.

Aspirin for Primary Prevention of Cardiovascular Disease.

Aspirin in primary prevention. Meta-analysis stratified by baseline cardiovascular risk.

Differences in the prevention and control of cardiovascular and cerebrovascular diseases.

Antiplatelet therapy with clopidogrel versus aspirin in atherosclerotic cardiovascular disease: a systematic review and meta-analysis.

Association Between Aspirin Use and Risk of Aneurysmal Subarachnoid Hemorrhage: A Meta-analysis.

The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis.

Comparing aspirin 75 to 81 mg vs 150 to 162 mg for prevention of preterm preeclampsia: systematic review and meta-analysis.

Does aspirin reduce the incidence, recurrence, and mortality of colorectal cancer? A meta-analysis of randomized clinical trials.

Association of Treatments for Myeloproliferative Neoplasms During Pregnancy With Birth Rates and Maternal Outcomes: A Systematic Review and Meta-analysis.

Low-versus high-dose aspirin for venous thromboembolic prophylaxis after total joint arthroplasty: a systematic review and meta-analysis.

Timing of Aspirin Use Among Patients With Colorectal Cancer in Relation to Mortality: A Systematic Review and Meta-Analysis.

Direct oral anticoagulants in embolic stroke of undetermined source: an updated meta-analysis.

Do We Need to Hold Aspirin Before Cataract Surgery? A Systematic Review and Meta-Analysis of 65,196 Subjects.

Efficacy and Safety of Aspirin-free versus Aspirin-based Strategies in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

No Significant Difference in Post-ERCP Bleeding Rates Between Dual Antiplatelet Agents and Aspirin Alone: A Systematic Review and Meta-analysis.

The effects of low-dose aspirin on preterm birth: a systematic review and meta-analysis of randomized controlled trials.

Antiplatelet dilemma: Clopidogrel or aspirin for long-term cardiovascular protection after dual antiplatelet therapy following PCI.