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Asa3.0

Aspirin (low-dose) Research

Mostly mechanism / observational

1,001 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Aspirin (low-dose) studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 2009–2026 with a typical study size of 760 participants.

Based on 1,001 studies · 307 meta-analyses · 653 RCTs · 179,343 total participants

Confidence

High confidence

By outcome

Cardiovascular preventionGenuinely reduces recurrent cardiovascular events in people with established cardiovascular disease (secondary prevention; no benefit shown in healthy older adults) · Ongoing daily use
Mostly mechanism / observational345 studies
Safety profile
Mostly mechanism / observational73 studies
Healthy aging & mortality
Mostly mechanism / observational11 studies

Active research area

517 studies in the last 5 years · Latest meta-analysis: 2026

200920172026

1Meta-Analysis2026

Ibrahim IA, Hamdy AM, Shehata MM, Elewa M, Elmandrawi SW, Elemam AME · Neurol Sci (2026)

Aspirin (low-dose) Research

Mostly mechanism / observational

Oral antipyretics for fatigue alleviation and exercise enhancement in adults with multiple sclerosis: a systematic review and meta-analysis.

Efficacy and safety of clopidogrel versus aspirin monotherapy for secondary prevention after percutaneous coronary intervention: a GRADE-assessed meta-analysis with trial sequential analysis.

Effectiveness and Safety of Aspirin Versus Other Antithrombotics for VTE After Total Hip and Knee Arthroplasty in Real-World Setting.

Aspirin Versus Other Anticoagulants for the Initial Prevention of Venous Thromboembolism Following Elective Total Hip and Knee Arthroplasty: An Umbrella Review and Meta-Analysis.

Ticagrelor-Based antiplatelet therapy versus aspirin alone after coronary artery bypass grafting: A systematic review and Meta-Analysis with trial sequential analysis.

Adjuvant aspirin and Cyclooxygenase-2 inhibitors in resected, PIK3CA-mutated colorectal cancer: A systematic review and meta-analysis of randomized controlled trials.

Low-Dose Aspirin and Prevention of Spontaneous Preterm Birth: Is It Worthwhile? A Systematic Review and Meta-Analysis.

Which antiplatelet is better after stents? A meta-analysis of aspirin vs clopidogrel in the maintenance phase.

Cutting Through the Clot: Rethinking Venous Thromboembolism Prophylaxis in Plastic Surgery with Aspirin, Direct Oral Anticoagulants, and Low Molecular Weight Heparin.

Optimal time for aspirin withdrawal after PCI in ACS: a pairwise and network meta-analysis with time to event data of randomized trials.

Antithrombotic agents in the treatment of severe mental illness: A systematic review and meta-analysis of randomized controlled trials.

Aspirin versus recombinant tissue plasminogen activator for acute minor stroke: a systematic review and meta-analysis.

Efficacy and Safety of Aspirin-free versus Aspirin-based Strategies in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Early aspirin withdrawal versus dual antiplatelet therapy in high-risk patients after percutaneous coronary intervention: Meta-analysis of randomized trials.

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) for preventing colorectal cancer and colorectal adenoma in the general population.

Indobufen Dual Antiplatelet Therapy (DAPT) Versus Aspirin Dual Antiplatelet Therapy (DAPT) After Percutaneous Coronary Intervention (PCI): A Systematic Review and Meta-Analysis.

Use of aspirin for prevention of hepatic artery thrombosis after liver transplantation: A systematic review and meta-analysis.

Safety and efficacy of ticagrelor plus aspirin vs. aspirin monotherapy in patients undergoing coronary artery bypass grafting: A meta-analysis with trial sequential analysis.

Clopidogrel versus aspirin monotherapy following dual antiplatelet therapy after percutaneous coronary intervention: an updated meta-analysis of 162,829 patients.

Efficacy of clopidogrel monotherapy versus aspirin monotherapy after percutaneous coronary intervention.