Bac8.5

Bacopa Monnieri Research

41 peer-reviewed studies · Evidence score: 8.5/10

Effectiveness of Bacopa Monnieri (Brahmi) in the management of schizophrenia: a systematic review

Ayilara GO et al. • Nutritional neuroscience (2025)

It is recommended that additional research elucidating the effects of Brahmi in other models of schizophrenia and the possible mechanisms of action be conducted.

Schizophrenia is a psychotic disorder affecting approximately 0.32% of the global population.
Data analysis was done by using themes.
The review found that Brahmi could reverse positive, negative, and cognitive symptoms of schizophrenia.

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Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review

Auditeau E et al. • Journal of ethnopharmacology (2019)

Species with the highest use report were not those with pharmacological evaluation.

Species with the highest use report were not those with pharmacological evaluation.
It will be pertinent to assess the pharmacological effects and safety of medicinal plants used mostly by traditional healers on predictive models of seizures.
Further research warranted to confirm findings

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Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review

Al Shahab S et al. • Nutrients (2025)

The evidence revealed the potential use of supplements as complementary ADHD treatments under clinical guidance.

The evidence revealed the potential use of supplements as complementary ADHD treatments under clinical guidance.
The limited effect of supplements cannot replace the well-documented efficacy of stimulants for ADHD treatment.
Additional studies are needed to ascertain the most effective dosages and the safety of these supplements as adjunctive treatments for ADHD.

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Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability

Gościniak A et al. • Nutrients (2025)

Further research is needed to determine optimal dosages and ensure safety, especially for pregnant and breastfeeding women.

Animal studies have shown promising results in reducing symptoms and protecting against neurodegeneration.
Concerning safety, Bacopa monnieri has been found to be generally non-toxic, with no serious side effects reported.
However, interactions with certain medications and contraindications in conditions like hyperthyroidism should be considered.

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The Role of Ayurveda in Prostate Cancer Management

Jabbari P et al. • Integrative cancer therapies (2025)

Despite strong evidence of efficacy of these plants to potentially improve the outcome of prostate cancer, clinical trials are required to evaluate which plants may be most efficacious and to determine effective dosing strategies, as well as the use of ayurvedic plants as standalone therapies or in combination with conventional prostate cancer treatments.

As such, there is an urgent need for novel therapeutic options in treating this malignancy.
This review examines the pre-clinical evidence for Ayurveda medicinal plants such as Withania somnifera, Glycyrrhiza spp, Momordica spp, Boswellia, and Bacopa monnieri and their potential application in managing prostate cancer.
Several in-vitro and pre-clinical studies suggest potentials for these plants or their derivatives in preventing or treating prostate cancers.

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Bacoside-A from Bacopa monnieri (L.) Wettst.: Molecular targets, preclinical insights, and therapeutic potential in type 2 diabetes mellitus and neurodegeneration

Dadhich A et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2025)

Network pharmacology and protein-protein interaction analyses confirm bacoside-A's regulatory roles in NOTCH signalling, insulin receptor expression, and hepatic enzyme modulation.

Network pharmacology and protein-protein interaction analyses confirm bacoside-A's regulatory roles in NOTCH signalling, insulin receptor expression, and hepatic enzyme modulation.
Collectively, these findings validate BM as a viable, low-toxicity candidate for next-generation phytopharmaceutical development in the holistic management of diabetes and its complications.

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Plant-derived nootropics and human cognition: A systematic review

Lorca C et al. • Critical reviews in food science and nutrition (2023)

Together, the results from the compiled studies highlight the nootropic effects and the inconsistencies regarding PDNs that require further research.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2021.2021137.

Bacopa monnieri improves language, learning and memory.
Withania somnifera (Ashwagandha) modulates anxiety and social-related cognitions.
Caffeine enhances attention and executive functions.

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Meta-analysis of Bacopa monnieri on cognitive function

Kongkeaw C et al. • Journal of Ethnopharmacology (2014)

Bacopa monnieri has the potential to improve attention, cognitive processing, and working memory.

Improved attention
Enhanced cognitive processing speed
Better working memory

Meta-Analysisn=437

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Investigating Bacopa monnieri L. Therapeutic Potential for the Treatment of Neurological Diseases

Srivastava P et al. • Current pharmaceutical design (2024)

Our review offers a more indepth molecular understanding of the neuroprotective functions of BME, which can also be connected to its therapeutic management of neurological illnesses and cognitive-improving effects.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Here, we focused on neurological problems as we examined the pharmacological and phytochemical characteristics of BME.
For their effective usage in neuroprotection and cognition, many clinical concerns and the synergistic potential of Bacopa extract have been investigated.
Alzheimer's disease is a neurological condition caused by the production of reactive oxygen species, which also causes amyloid-beta (Aβ) and tau protein aggregation and increases neuro-inflammation and neurotoxicity.

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Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials

Lopresti AL et al. • Nutritional neuroscience (2022)

For most phytonutrients, the effects of supplementation on HPA-axis activity in humans is unclear.

For most phytonutrients, the effects of supplementation on HPA-axis activity in humans is unclear.
Before more definitive conclusions about the effects of phytonutrients on the HPA-axis can be made, further research is required.
Further research warranted to confirm findings

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Bacopa monnieri for Disorders Affecting Brain: Current Perspectives

Vinod A et al. • Current topics in medicinal chemistry (2022)

To propel the clinical translation of BM in disorders affecting the brain, strategies to improve brain delivery via novel formulations and integration of the preclinical findings into large and well-defined clinical trials, in appropriate age groups and sex, specifically in the patient population against existing medications as well as placebo, are essentially required.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

The active constituents and metabolites responsible for the effects of BM could be bacoside A and B, bacopaside I and II, bacopasaponin C, betulinic acid, asiatic acid, loliolide, ebelin lactone, and quercetin.
We have also discussed CDRI-08, clinical trials, safety, emerging formulation technologies, as well as BM combinations, and dietary supplements.
Further research warranted to confirm findings

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Ameliorative Effects of Phytomedicines on Alzheimer's Patients

Khandia R et al. • Current Alzheimer research (2022)

The present review is a comprehensive and up-to-date analysis supported by the evidentiary proofs from pre-clinical studies, meta-analyses, and review papers related to natural phytochemicals' impact on neurodegenerative disorders like AD.

The present review is a comprehensive and up-to-date analysis supported by the evidentiary proofs from pre-clinical studies, meta-analyses, and review papers related to natural phytochemicals' impact on neurodegenerative disorders like AD.
Further research warranted to confirm findings

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Role of Medicinal Plants against Neurodegenerative Diseases

Luthra R et al. • Current pharmaceutical biotechnology (2022)

This review deals with the use of different medicinal plants for the prevention of neurodegenerative diseases.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Variation in transcription and transduction pathways plays a vital role in the preventive measures of plants in such diseases.
Neurodegenerative diseases are generally caused by the depletion of proteins, oxidative and inflammatory stress, environmental changes and so on, with aging being the most important cause.
Natural compounds can be used in order to treat neurodegenerative diseases Medicinal plants such as Ginseng, Withania somnifera, Bacopa monnieri, Ginkgo biloba, etc. are some of the medicinal plants for the prevention of neurological symptoms.

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Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review

Crawford C et al. • Journal of alternative and complementary medicine (New York, N.Y.) (2021)

Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.

Ingredients evaluated included Bacopa monnieri, choline, creatine, omega-3 fatty acids, Ginkgo biloba, ginseng, Rhodiola rosea, tyrosine, and valerian root, all in supplement form and compared with a placebo, at various serving sizes and durations of use.
Whereas certain trends regarding promising serving sizes or duration for use, are pointed to in this synthesis, when combined, studies are inconsistent and imprecise, and many are methodologically flawed.
Potential solutions to address research gaps are offered, for future research next steps, which is needed to strengthen the evidence and inform decisions.

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Neuroprotection with Bacopa monnieri-A review of experimental evidence

Shalini VT et al. • Molecular biology reports (2021)

The review demonstrates the neuroprotective potential of the Ayurveda herb Brahmi in several disorders including Alzheimer's disease, epilepsy, Parkinson's disease, Huntington's disease, cerebral ischemia and infarct and neoplasms.

Numerous research have been undertaken across the globe to evaluate the neuroprotective potential of this herb.
This review collates and summarises current (as on May 2020) published literature on Brahmi as a neuroprotective in neurological and psychiatric disorders.
English language articles from databases PubMed, Scopus and Google scholar were searched using appropriate free keywords and MeSH terms related to the topic.

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The Evolving Roles of Bacopa monnieri as Potential Anti-Cancer Agent: A Review

Ghosh S et al. • Nutrition and cancer (2021)

This comprehensive review covers literature up to the year 2020 highlighting all the anticancer efficacy along with signaling pathways activated by secondary metabolites found in bacopa plant.

In recent years, research on the biological effects of Bacopa monnieri has flourished as promising neuroprotective, memory boosting and more importantly as both chemopreventive and anti-neoplastic agent.
Each naturally synthesized chemical constituent identified from Bacopa monnieri leaf extract with different solvents, has significant anti-metastatic, anti-angiogenic and anti-proliferative activity on different type of cancer cells.
In this context, a substantial literature survey allows a deep understanding of the involvement of specific bioactive molecules along with the whole plant extract of Bacopa monnieri with their divergent effective molecular pathways.

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The Safety and Efficacy of Botanicals with Nootropic Effects

Roe AL et al. • Current neuropharmacology (2021)

Data gaps are highlighted for both efficacy and safety to bring attention to unmet needs and future research.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Overall, nearly one-quarter (23%) of adults currently take a supplement to maintain or improve brain health or delay and reverse dementia.
However, other botanicals that affect stress, focus, attention, and sleep have also been procured by dietary supplement companies developing products for improving both, short and long-term brain health.
Botanicals are discussed in terms of available clinical efficacy data and current safety profiles.

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A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment

Cave AE et al. • Systematic reviews (2023)

Overall, this review found that there is a low quality of evidence regarding the efficacy of cognitive function and safety of herbal and nutritional medicines for older adults with and without SCI, due to a high risk of bias across studies.

Overall, this review found that there is a low quality of evidence regarding the efficacy of cognitive function and safety of herbal and nutritional medicines for older adults with and without SCI, due to a high risk of bias across studies.
Additionally, further work needs to be done in classifying and understanding SCI and selecting appropriate trial primary outcomes before future studies can more accurately determine the efficacy of interventions for this population.
Further research warranted to confirm findings

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Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Sangiovanni E et al. • Neural plasticity (2017)

Further clinical studies are mandatory to confirm botanicals as preventive agents or as useful adjuvant to the pharmacological treatment.

The effect of the active principles responsible for the efficacy of the extracts is reviewed and discussed as well.
The high number of articles published (more than one hundred manuscripts for 14 botanicals) supports the growing interest in the use of natural products as BDNF modulators.
The studies reported strengthen the hypothesis that botanicals may be considered useful modulators of BDNF in CNS diseases, without high side effects.

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A systematic review of the Ayurvedic medicinal herb Bacopa monnieri in child and adolescent populations

Kean JD et al. • Complementary therapies in medicine (2016)

This review highlights the safe use of Bacopa monnieri in child and adolescent populations for improving elements of cognition as well as behaviour and attention-deficit domains.

Significant improvements were also seen in hyperactivity and attention-deficit domains.
Overall outcome data demonstrated small to medium effect sizes (mean d=0.42).
Safety and tolerability data was well reported for 80% of studies with only 2.3% of all participants reporting mild side-effects.

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