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Bfl2.5

Beef Liver Research

Mostly mechanism / observational

5 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Beef Liver studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 1996–2022 with a typical study size of 10 participants.

Based on 5 studies · 1 RCT · 11 total participants

Confidence

Low confidence

Steady research

1 study in the last 5 years

199620092022

1RCT2017

Duizer LM, Diana A, Rathomi HS, Luftimas DE, Rahmannia S, Santi W · J Food Sci (2017)

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2Pilotn=10 · very small study1996

In plain English: A single meal of liver contains, on average, a 10- to 20-fold higher amount of vitamin A than what is already suspected to be teratogenic.

Arnhold T, Tzimas G, Wittfoht W, Plonait S, Nau H. · Life Sci (1996)

Eating liver produced sharply elevated plasma retinoic-acid metabolites, including the potent teratogen 9-cis-retinoic acid, in healthy volunteers
A single liver meal can deliver 10-20x the vitamin A amount suspected to be teratogenic
Directly supports the pregnancy contraindication

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3In Vitro2014

In plain English: Liver had the highest vitamin A, B2 and niacin contents, and the highest copper content, among the edible bovine by-products examined.

Seong PN, Kang GH, Park KM, et al. · Korean J Food Sci Anim Resour (2014)

Liver had the highest vitamin A, riboflavin (B2), niacin and copper content of all bovine by-products analyzed
Confirms liver's high micronutrient density at a compositional level
Compositional analysis of meat, not a human efficacy study

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4Case Studyn=1 · very small study2022

In plain English: Vitamin A toxicity can lead to serious liver injury and should be considered in the differential diagnosis of chronic liver disease.

Arisheva OS, Avdoshina SV, Goreva LA, Markova MA. · Ter Arkh (2022)

Chronic high vitamin A intake produced cirrhosis-like portal hypertension and liver failure
Liver biopsy showed characteristic signs of hypervitaminosis A
Symptoms fully regressed after stopping vitamin A

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5Review2018

In plain English: Organ meat is proposed as an affordable, nutrient-dense diet to meet daily protein and micronutrient requirements.

Fayemi PO, Muchenje V, Yetim H, Ahhmed A. · Food Res Int (2018)

Reviews organ meat (including liver) as a dense source of protein and micronutrients for addressing malnutrition
Frames the rationale as nutrient density, not treatment of a specific clinical condition
A narrative review, not a controlled efficacy trial

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View in Research Library

Beef Liver Research

Mostly mechanism / observational

An Acceptability Trial of Desiccated Beef Liver and Meat Powder as Potential Fortifiers of Complementary Diets of Young Children in Indonesia.

Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption.

Characterization of Hanwoo Bovine By-products by Means of Yield, Physicochemical and Nutritional Compositions.

[The development of portal hypertension and liver failure on the background of long-term intake of vitamin A in a young woman. Case report].

Targeting the pains of food insecurity and malnutrition among internally displaced persons with nutrient synergy and analgesics in organ meat.