1 In Vitro 2014
Liver had the highest vitamin A, B2 and niacin contents, and the highest copper content, among the edible bovine by-products examined.
Characterization of Hanwoo Bovine By-products by Means of Yield, Physicochemical and Nutritional Compositions. Seong PN, Kang GH, Park KM, et al. · Korean J Food Sci Anim Resour (2014)
Liver had the highest vitamin A, riboflavin (B2), niacin and copper content of all bovine by-products analyzed Confirms liver's high micronutrient density at a compositional level Compositional analysis of meat, not a human efficacy study 2 Pilot n=10 · very small study1996 A single meal of liver contains, on average, a 10- to 20-fold higher amount of vitamin A than what is already suspected to be teratogenic.
Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption. Arnhold T, Tzimas G, Wittfoht W, Plonait S, Nau H. · Life Sci (1996)
Eating liver produced sharply elevated plasma retinoic-acid metabolites, including the potent teratogen 9-cis-retinoic acid, in healthy volunteers A single liver meal can deliver 10-20x the vitamin A amount suspected to be teratogenic Directly supports the pregnancy contraindication 3 Case Study n=1 · very small study2022 Vitamin A toxicity can lead to serious liver injury and should be considered in the differential diagnosis of chronic liver disease.
[The development of portal hypertension and liver failure on the background of long-term intake of vitamin A in a young woman. Case report]. Arisheva OS, Avdoshina SV, Goreva LA, Markova MA. · Ter Arkh (2022)
Chronic high vitamin A intake produced cirrhosis-like portal hypertension and liver failure Liver biopsy showed characteristic signs of hypervitaminosis A Symptoms fully regressed after stopping vitamin A 4 Review 2018
Organ meat is proposed as an affordable, nutrient-dense diet to meet daily protein and micronutrient requirements.
Targeting the pains of food insecurity and malnutrition among internally displaced persons with nutrient synergy and analgesics in organ meat. Fayemi PO, Muchenje V, Yetim H, Ahhmed A. · Food Res Int (2018)
Reviews organ meat (including liver) as a dense source of protein and micronutrients for addressing malnutrition Frames the rationale as nutrient density, not treatment of a specific clinical condition A narrative review, not a controlled efficacy trial