1Meta-Analysis2025
Xie S, Galimberti F, Olmastroni E, Carugo S, Catapano AL, Casula M · Atherosclerosis (2025)
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93 peer-reviewed studies
What the evidence says
Most Bempedoic Acid studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2016–2026 with a typical study size of 238 participants.
Based on 93 studies · 36 meta-analyses · 32 RCTs · 123,439 total participants
Confidence
High confidenceBy outcome
76 studies in the last 5 years · Latest meta-analysis: 2026
Xie S, Galimberti F, Olmastroni E, Carugo S, Catapano AL, Casula M · Atherosclerosis (2025)
Del Carpio-Tenorio C, Llerena-Velastegui J, Villacis-Lopez C, Placencia-Silva M, Santander-Fuentes C, Benitez-Acosta K · Curr Probl Cardiol (2024)
Laohapiboolrattana W, Kosum P, Nimworapan M, Dilokthornsakul P, Boonpattharatthiti K, Theerasuwipakorn N · J Clin Lipidol (2025)
Wang X, Luo S, Gan X, He C, Huang R · Kardiol Pol (2019)
Dai L, Zuo Y, You Q, Zeng H, Cao S · Eur J Prev Cardiol (2021)
Li Y, Gao H, Zhao J, Ma L, Hu D · PLoS One (2024)
Whitney KR · JAAPA (2021)
Mutschlechner D, Tscharre M, Huber K, Gremmel T · Eur Heart J Cardiovasc Pharmacother (2023)
Sayed A, Shazly O, Slipczuk L, Krittanawong C, Baloch F, Virani SS · Cardiovasc Drugs Ther (2024)
Toth PP, Bray S, Villa G, Palagashvili T, Sattar N, Stroes ESG · J Am Heart Assoc (2022)
Goyal A, Changez MIK, Tariq MD, Mushtaq F, Shamim U, Sohail AH · Curr Probl Cardiol (2024)
Bhagavathula AS, Al Matrooshi NO, Clark CCT, Rahmani J · Clin Drug Investig (2021)
Lin Y, Parco C, Karathanos A, Krieger T, Schulze V, Chernyak N · BMJ Open (2022)
De Filippo O, D'Ascenzo F, Iannaccone M, Bertaina M, Leone A, Borzillo I · Cardiovasc Diabetol (2023)
Masson W, Lobo M, Lavalle-Cobo A, Molinero G · Clin Investig Arterioscler (2021)
Zhao X, Ma X, Luo X, Shi Z, Deng Z, Jin Y · BMC Pharmacol Toxicol (2020)
Burnett H, Fahrbach K, Cichewicz A, Jindal R, Tarpey J, Durand A · Curr Med Res Opin (2022)
Uddin N, Syed AA, Ismail SM, Ashraf MT, Khan MK, Sohail A · Curr Probl Cardiol (2023)
Wang X, Zhang Y, Tan H, Wang P, Zha X, Chong W · Cardiovasc Diabetol (2020)
Khan MU, Khan MZ, Munir MB, Balla S, Khan SU · Am J Cardiol (2020)