Citrus Bergamot Extract
Citrus extract with compelling evidence for cholesterol management, particularly LDL reduction and improved lipid ratios.
Bergamot is a citrus fruit from southern Italy whose polyphenolic fraction (BPF) has shown remarkable effects on cholesterol metabolism. Studies show it can reduce LDL cholesterol, triglycerides, and blood sugar while raising HDL. Works through similar pathways to statins but without the muscle side effects. A promising natural option for cardiovascular health.
Naturally influences cholesterol synthesis
Improves metabolic function
How Bergamot works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
500-1000mg bergamot polyphenolic fraction (BPF)
Take with food
| Form | Type |
|---|---|
| 💊Bergamot polyphenolic fraction (BPF) — Bergamonte is well-studied | Recommended |
| 💊Citrus bergamot extract | Alternative |
Look for standardized BPF content. Bergamonte is a patented, clinically studied extract.
Minimum: 8 weeks
Optimal: 16 weeks
Cycling: Not required
Note: Can be taken with any meal. Often dosed 500mg twice daily or 1000mg once daily.
Significant decrease in LDL cholesterol
Lower triglycerides
Modest increase in good cholesterol
Insufficient data; consult doctor
May have additive effects — could allow lower statin doses
Like grapefruit, may affect some drug metabolism
Tip: Take with food
Tip: Take with food
Top studies from 39+ peer-reviewed papers
Sandborn WJ et al. • The lancet. Gastroenterology & hepatology (2023)
“A significantly higher proportion of patients with moderately to severely active Crohn's disease achieved clinical remission and endoscopic improvement with etrolizumab than placebo during maintenance, but not during induction.”
Osadnik T et al. • Pharmacological research (2022)
“Evidence for bergamot effect was based on relatively small study group and may require further investigations.”
Protic O et al. • Nutrients (2022)
“The evaluated nutraceutical combination did not change serum lipid profile and inflammatory parameters, at least not with the daily dose applied in the present study.”
Lamiquiz-Moneo I et al. • Critical reviews in food science and nutrition (2020)
“Promising findings reveal an alternative therapeutic option in dyslipidemia management with bergamot supplementation, especially in subjects with statins intolerance.”
Mannucci C et al. • Phytotherapy research : PTR (2017)
“Supplementation with polyphenols from bergamot juice reduces plasma lipids and improves lipoprotein profile in moderate hyperlipidemia.”
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