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Bgm8.5
Bergamot Research
Likely helpsHigh safety
25 peer-reviewed studies
What the evidence says
Likely helps
Bergamot appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2014–2026 with a typical study size of 98 participants.
Based on 25 studies · 2 meta-analyses · 18 RCTs · 15,002 total participants
Confidence
High
What the studies found
4helped· 21 more without graded effect data
By outcome
Cholesterol & lipidsImproved cholesterol ratios and cardiovascular markers within 4-8 weeks · 4-8 weeks
Likely helps23 studies
InflammationSignificant LDL and triglyceride reduction · 4-12 weeks
Mostly mechanism / observational7 studies
Weight management
Likely helps7 studies
Heart & blood pressureImproved cholesterol ratios and cardiovascular markers within 4-8 weeks · 4-8 weeks
2Systematic ReviewCited 26×n=442 · medium study2020
Promising findings reveal an alternative therapeutic option in dyslipidemia management with bergamot supplementation, especially in subjects with statins intolerance.
Lamiquiz-Moneo I et al. · Critical reviews in food science and nutrition (2020)
Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL targets.
Based on data, 75% of studies showed a significant decrease in total cholesterol, triglycerides and LDLc.
The decrease in total cholesterol varied from 12.3% to 31.3%, from 7.6% to 40.8% in LDLc and from 11.5% to 39.5% in triglycerides.
Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.
Rondanelli M et al. · BioMed research international (2016)
The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels.
Various MediterrAsian diet products or natural extracts may represent a potential intervention treatment to raise HDL-C in dyslipidemic subjects.
Preclinical data suggest that polyphenols are potent multifunctional agents capable of breaking the feedback loops of cardiorenal injury.
Carollo C et al. · Nutrients (2026)
Preclinical data suggest that polyphenols are potent multifunctional agents capable of breaking the feedback loops of cardiorenal injury.
While bioavailability remains a significant translational challenge, novel nano-delivery systems and synthetic analogs offer promising strategies for clinical application.
Integrating these bioactives into CRS management could provide a decisive adjunctive strategy to improve metabolic homeostasis and prevent end-stage organ failure.
6Serum lipid profile and inflammatory parametersRCTCited 9×n=118 · medium study2022
The evaluated nutraceutical combination did not change serum lipid profile and inflammatory parameters, at least not with the daily dose applied in the present study.
Protic O et al. · Nutrients (2022)
Borderline
Compared to the placebo, at 6 and 12 weeks, NC did not significantly reduce total cholesterol (p = 0.083), LDL cholesterol (p = 0.150), and triglycerides (p = 0.822).
No changes were found in hs-CRP (p = 0.179), interleukin-32 (p = 0.587), interleukin-38 (p = 0.930), miR-21 (p = 0.275), miR-126 (p = 0.718), miR-146a (p = 0.206), myoglobin (p = 0.164), and creatine kinase (p = 0.376).
The evaluated nutraceutical combination did not change serum lipid profile and inflammatory parameters, at least not with the daily dose applied in the present study.
7Cardiometabolic risk factorsRCTCited 5×n=90 · small study2024
Overall, these findings support the use of the tested dietary supplement containing dry extracts of bergamot and artichoke as a safe and effective approach for the prevention and management of a broad spectrum of cardiometabolic disorders.
Fogacci F et al. · Nutrients (2024)
Borderline
After 6 weeks, the active-treated group experienced significant improvements in levels of triglycerides (TG), apolipoprotein B-100 (Apo B-100), and apolipoprotein AI (Apo AI) versus baseline.
Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high density lipoprotein cholesterol (Non-HDL-C), and hs-CRP also significantly decreased in the active-treated group compared to both baseline and placebo.
Improvements in TC, LDL-C, Non-HDL-C, TG, fatty liver index (FLI), hs-CRP, and endothelial reactivity were also detected compared to placebo (p < 0.05 for all).
9Athletic performance and vasodilationRCTCited 1×2025
Given the small sample size, this study serves as a pilot, and further research is needed to validate these findings on a larger scale.
Mollace R et al. · Nutrients (2025)
No harmful adverse effects were observed.
Max supplementation, providing beneficial effects on the antioxidant state and preserving the vascular endothelium might be a supplementation strategy to improve athletic performance and potentiate results.
Given the small sample size, this study serves as a pilot, and further research is needed to validate these findings on a larger scale.
10Liver fat content reductionRCTCited 18×n=140 · medium study2022
Our results showed that a new combination of bioactive molecules as nutraceutical was safe and effective in reducing liver fat content over 12 weeks in individuals with hepatic steatosis.
Ferro Y et al. · Journal of translational medicine (2022)
The CAP score reduction (%) was even greater in those with aged 60 or less, low baseline HDL-C, AST reduction as well as in men.
Our results showed that a new combination of bioactive molecules as nutraceutical was safe and effective in reducing liver fat content over 12 weeks in individuals with hepatic steatosis.
In conclusion, the synergism between Citrus Bergamia polyphenols and Cynara cardunculus extracts may be an effective option and may potentially broaden the therapeutic role of botanicals in dyslipidemic patients.
Riva A et al. · Nutrients (2021)
Between the two groups, total and LDL cholesterol in the supplemented group (compared to placebo) showed significant decreases overtime.
A significant reduction of waist circumference and visceral adipose tissue (VAT) was recorded in the supplemented group (compared to placebo), even in subjects who did not follow a low-calorie diet.
The metabolic parameters and DXA body composition were evaluated at the start, after 30 and 60 days.
12Fasting plasma glucose and lipid parametersRCTCited 58×n=60 · small study2019
These data suggest that better absorption and tissue distribution of BPF Phyto formulation represents an innovative approach in supplementation treatments of cardiometabolic disorders.
Mollace V et al. · Endocrine, metabolic & immune disorders drug targets (2019)
In the groups receiving BPF and BPF Phyto, a significant reduction of fasting plasma glucose, serum LDL cholesterol and triglycerides accompanied by increased HDL cholesterol was observed.
This effect was associated with significant reduction of small dense atherogenic LDL particles, as detected by means of proton NMR Spectroscopy, thus confirming the hypolipemic and hypoglycemic effect of bergamot extract both when using standard formulation as well as BPF Phyto.
However, when comparing the pharmacokinetic profile of naringin (the major component of BPF) and its metabolites, in patients treated with BPF Phyto, an at least 2,5 fold increase in its absorption was found, confirming in human studies the better profile of BPF Phyto compared to standard BPF.
13Visceral adipose tissue and plasma lipid profilesRCTCited 18×n=64 · small study2021
Phytotherapy Research
Rondanelli M et al. · Phytotherapy research : PTR (2021)
As to the within differences, the parameters of VAT, total and LDL-cholesterol were significantly decreased in the bergamot phytosome group, but not in the placebo group.
The other parameters (glucose, insulin, Homeostasis Model Assessment, high-density lipoprotein cholesterol, triglycerides, fat free mass, fat mass) were not significant.
Ferro Y et al. · Frontiers in endocrinology (2020)
Huge benefit
← WorseNo effectBetter →
Likely real
However, after adjustment for weight change, the percentage CAP score reduction was statistically significant only in those over 50 years (44 vs. 78% in placebo and nutraceutical, respectively, p = 0.007).
Conclusions: This specific nutraceutical containing bioactive components from Bergamot and wild cardoon reduced the liver fat content during 12 weeks in individuals with liver steatosis over 50 years.
If confirmed, this nutraceutical could become the cornerstone treatment of patients affected by liver steatosis.
15Glucose, lipid and inflammatory biomarkersRCTCited 1×n=45 · small study2024
BBB consumption is a safe nutritional adjunct in the context of a well balanced diet.
Maggiolo G et al. · Food & function (2024)
Aim: To assess the effects, if any, of a bergamot-based beverage (BBB, bergamot juice ≤25%) on lipid, metabolic and inflammatory biomarkers.
Methods: Forty-five healthy subjects were randomised 1 : 1 to BBB intake (400 mL day-1) (55.5%) or control (44.5%) for 12 weeks.
Results: Both groups exhibited a time-related significant decrease in total cholesterol (p = 0.02), fasting plasma glucose (p = 0.016), insulin (p = 0.034), BMI (p < 0.001) and waist circumference (p = 0.04), but with no significant between-arm difference.
16Oxidative stress and inflammation gene expressionRCTCited 20×n=24 · very small study2023
These data based on the nutrigenomics approach demonstrated that supplementing 2 weeks of MAB juice to the MedDiet could contribute to a reduction in the risk of CNCDs.
Gualtieri P et al. · Genes (2023)
Likely real
Moreover, a significant reduction in total cholesterol/HDL index (p < 0.01) was pointed out between the two groups.
Body composition evaluation analysis showed a gain in lean mass (p < 0.01).
Gene expression analysis highlighted an increase in MIF (p ≤ 0.05), PPARγ (p < 0.001), SOD1 (p ≤ 0.05), and VDR (p ≤ 0.05) expressions when comparing MedDiet and MedDiet + MAB juice groups.
20Lipid and glucose metabolism, adipokines pattern, and systemic inflammationRCTCited 33×n=90 · small study2019
The tested nutraceutical showed to improve lipid and glucose metabolism, adipokines pattern, and systemic inflammation in dyslipidemic overweight subjects.
Cicero AFG et al. · Phytotherapy research : PTR (2019)
After 8 weeks, all active-treated groups experienced a significant improvement in triglycerides (TG) versus placebo and in low-density lipoprotein cholesterol (LDL-C) versus baseline and placebo treatments.
In the high-dose-treated group, also total cholesterol (TC), nonhigh-density lipoprotein cholesterol (non-HDL-C), γ-glutamil transpeptidasi, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor-α (TNF-α) significantly decreased.
All patients allocated to either low-dose or high-dose active treatment experienced a significant decrease in TG, LDL-C, and homeostatin model assessment of insulin resistance.