We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Bs7.5
Beta-Sitosterol Research
Likely helps
72 peer-reviewed studies
What the evidence says
Likely helps
Beta-Sitosterol appears to help in 4 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1976–2026 with a typical study size of 519 participants.
Based on 72 studies · 10 meta-analyses · 52 RCTs · 39,631 total participants
14 studies in the last 5 years · Latest meta-analysis: 2026
197620012026
1Asthma treatment effectivenessMeta-Analysisn=1,200 · large study2025
In plain English: QJWJ is effective in the treatment of asthma, and the therapeutic mechanism may be related to its regulation of inflammation, immunity, and apoptosis.
Zhang L et al. · Medicine (2025)
QJWJ is effective in the treatment of asthma, and the therapeutic mechanism may be related to its regulation of inflammation, immunity, and apoptosis.
3Gouty arthritis treatment effectivenessMeta-Analysisn=7,151 · very large study2024
In plain English: TCMD could be a satisfactory complementary and alternative therapy for GA.
Qu P et al. · Medicine (2024)
TCMD could be a satisfactory complementary and alternative therapy for GA.
However, it should be verified by further studies.
Future research could be conducted from the following active ingredients, targets, and signal pathways, such as wogonin, sitosterol, and sitosterol; AKT1, TNF, IL6, and TP53; and IL-17, HIF-1, and PI3K-AKT signaling pathway.
4Serum levels of campesterolMeta-Analysisn=9,758 · very large study2024
In plain English: This meta-analysis examined the effects of Beta-Sitosterol.
Alenbawi J et al. · Human genomics (2024)
The meta-analysis replicated most of the reported variants, and our study provided significant support for the association of variants in SCARB1 and ABO with sitosterolemia.
Evaluation of a polygenic risk score devised from European GWAS data showed moderate performance when applied to QBB (adjusted-R2 = 0.082).
These findings provide new insights into the genetic architecture of phytosterol metabolism while showing the importance including under-represented populations in future GWAS studies.
In plain English: This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
Ulbricht CE · Journal of dietary supplements (2016)
An evidence-based systematic review of beta-sitosterol, sitosterol (22,23-dihydrostigmasterol, 24-ethylcholesterol) by the Natural Standard Research Collaboration consolidates the safety and efficacy data available in the scientific literature using a validated, reproducible grading rationale.
This article includes written and statistical analysis of clinical trials, plus a compilation of expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.
12Antidiabetic activity of natural compoundsSystematic Review2018
In plain English: This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
Munhoz ACM et al. · Current diabetes reviews (2018)
This review contributes to the field of ethnopharmacology and should impact the design of new strategies in the search of novel compounds for the treatment of diabetic conditions.
In plain English: It also notes gaps in current knowledge, underscoring the need for well-designed translational studies and randomized clinical trials to determine proper dosing, safety, and long-term effectiveness before these compounds can be fully used in clinical practice.
Shah FI et al. · Reproductive sciences (Thousand Oaks, Calif.) (2026)
Emphasizing their mechanistic actions, the review highlights targeting the CYP17A1–AR signaling axis and the AMPK–GLUT4 metabolic pathway, key intersections between endocrine disturbances and metabolic dysregulation.
It also notes gaps in current knowledge, underscoring the need for well-designed translational studies and randomized clinical trials to determine proper dosing, safety, and long-term effectiveness before these compounds can be fully used in clinical practice.
16Anticancer mechanisms of plant sterolsReview2026
In plain English: The unique contribution of this review lies in proposing a comparative mechanistic framework for stigmasterol, campesterol, and β-sitosterol, integrating their multi-targeted actions across key oncogenic signaling pathways to highlight their collective potential in anticancer therapy.
Menaga S et al. · Cell biochemistry and function (2026)
Despite extensive individual studies, a comprehensive review summarizing their collective anticancer mechanisms is lacking.
This work bridges that gap by systematically analyzing literature from the past 10 years across major databases, including Google Scholar, ScienceDirect, Scopus, Wiley Online Library, and Web of Science.
Evidence from preclinical, clinical, and pharmacological studies was critically evaluated to highlight the therapeutic potential of these sterols in tumor suppression and apoptosis, providing a consolidated foundation for future drug discovery and development.
18LDL cholesterol levelsRCTn=109 · medium study2024
In plain English: These findings support the efficacy of United Kingdom SFA dietary guidelines for the overall lowering of serum LDL cholesterol but showed marked variation in LDL cholesterol response.
Koutsos A et al. · The American journal of clinical nutrition (2024)
Likely real
There was also an increase in plasma biomarkers of cholesterol intestinal absorption (β-sitosterol, campesterol, cholestanol), and synthesis (desmosterol) (P < 0.0001) and fold change in PBMC LDL-receptor mRNA expression relative to the higher-SFA/lower-UFA diet (P = 0.035).
These findings support the efficacy of United Kingdom SFA dietary guidelines for the overall lowering of serum LDL cholesterol but showed marked variation in LDL cholesterol response.
Further identification of the determinants of this variation will facilitate targeting and increasing the efficacy of these guidelines.